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Chemical Society Reviews, 2020
Cancer is among the leading causes of death worldwide. Although a number of new treatment options have been developed in recent years, there remains a need for improved chemotherapies. The primary challenges facing new cancer drugs include: (1) improving
Axel Steinbrueck +9 more
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Cancer is among the leading causes of death worldwide. Although a number of new treatment options have been developed in recent years, there remains a need for improved chemotherapies. The primary challenges facing new cancer drugs include: (1) improving
Axel Steinbrueck +9 more
semanticscholar +1 more source
Veterinary Clinics of North America: Equine Practice
Ionophores are a class of polyether antibiotics that are commonly used as anticoccidial agents and growth promotants in ruminant diets. Ionophores transport ions across lipid membranes and down concentration gradients, which results in mitochondrial destruction, reduced cellular energy production, and ultimately cell death.
Scott A, Fritz, Jeffery O, Hall
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Ionophores are a class of polyether antibiotics that are commonly used as anticoccidial agents and growth promotants in ruminant diets. Ionophores transport ions across lipid membranes and down concentration gradients, which results in mitochondrial destruction, reduced cellular energy production, and ultimately cell death.
Scott A, Fritz, Jeffery O, Hall
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Chemical syntheses and chemical genetics of carboxyl polyether ionophores: Recent highlights.
Angewandte Chemie, 2019A central goal of chemical genetics is to develop molecular probes that enable fundamental studies of cellular systems. In the hierarchy of bioactive molecules, the so-called ionophore-class occupies an unflattering position in the lower branches: with ...
Han Liu +3 more
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Ionophore-Based Optical Sensors
Annual Review of Analytical Chemistry, 2014This review provides an overview of the key aspects of designing ionophore-based optical sensors (IBOS). Exact response functions are developed and compared with a simplified, generalized equation. We also provide a brief introduction into less established but promising working principles, namely dynamic response and exhaustive exchange. Absorbance and
Mistlberger, Gunter +2 more
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Chemiluminescent Ion Sensing Platform Based on Ionophores.
Analytical Chemistry, 2019We report here an ionophore-based chemiluminescent platform for the selective detection of ions. This method functions on the basis of the ion-exchange between the target ion and the divalent organic cation lucigenin, which luminesces after reacting with
Li Deng, Jingying Zhai, Xiaojiang Xie
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Journal of Chemical Education, 1979
Discovery, structure, and mechanism of ionophores, molecular complexes that pass through biological membranes.
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Discovery, structure, and mechanism of ionophores, molecular complexes that pass through biological membranes.
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Ionophores as Potent Anti-malarials: A Miracle in the Making.
Current Topics in Medicinal Chemistry, 2019Plasmodium has a complex life cycle that spans between mosquito and human. For survival and pathogenesis it banks upon dynamic alterations in ionic transport across organelle and plasma membrane.
Hina Bharti +4 more
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Is Avenaciolide Another Ionophore?
Nature New Biology, 1973THE neutral dilactone, avenaciolide1, has been reported to block glutamate transport in mitochondria2 and has been used to obtain a measure of glutamate binding sites on the membrane3.
E J, Harris, J M, Wimhurst
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Conformationally switched-on polyether ionophores
Chirality, 1998The syntheses of two types of conformationally switched podand ionophores and their ionophoric properties are described. Both feature cyclohexane rings with polyether groups as trans 1,2 substituents. In the “switched off” forms of the ionophores, the two podand substituents are constrained to a diaxial orientation and cannot chelate a metal ion.
Morton Raban +4 more
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