Results 131 to 140 of about 55,204 (263)
Consciousness operates beyond the timescale for discerning time intervals: implications for Q-mind theories and analysis of quantum decoherence in brain [PDF]
This paper presents in details how the subjective time is constructed by the brain cortex via reading packets of information called "time labels", produced by the right basal ganglia that act as brain timekeeper.
Georgiev, Danko
core
Efficient and rapid isolation of native AMPA receptor complexes for cryo‐EM
Abstract Isolating native ion channels for structural characterization is routinely achieved by extraction from membrane fractions of tissue with prolonged mild detergent treatment. AMPA receptors (AMPARs), glutamatergic receptors that mediate fast excitatory transmission and synaptic plasticity, are coassembled with diverse auxiliary subunits and ...
Jumi Park, Eric Gouaux
wiley +1 more source
The bed bug olfactory system is highly tuned to two odor sources with dedicated odor information‐processing pathways that are modulated by the satiety–hunger state. Understanding the dynamic nature of switching odor preferences at different phases of blood digestion will contribute to the development of lures with host kairomones and aggregation ...
Ayako Wada‐Katsumata +4 more
wiley +1 more source
ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando +7 more
wiley +1 more source
Background and Purpose Riluzole, approved for amyotrophic lateral sclerosis (ALS), has a glutamate‐modulating profile favourable for mitigating opioid addiction. It reduces neuronal glutamate release and enhances glutamate reuptake, offering advantages over agents that only increase glutamate reuptake.
Ewa Galaj +7 more
wiley +1 more source
Integrating the inputs that shape pancreatic islet hormone release. [PDF]
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
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Glutamate partner drives gamma-glutamyl-dipeptide effects on ionotropic glutamate receptors
Gamma-glutamyl dipeptides are yielded by the condensation of glutamate with another amino acid on the gamma position. Their synthesis results from the hydrolysis of glutathione (GSH ; gamma-Glu-Cys-Gly) by gamma- glutamyl transferase (GGT). In fact, while g-glutamyl dipeptides have been detected in different organs and fluids of the body, especially in
Rolland, Valérie +13 more
openaire +1 more source
Thiolated hyaluronic acid (HAMS) synthesized and characterized by NMR, solubility, thiol content, and pKa, is degraded by Staphylococcal hyaluronate lyase but not by mammalian hyaluronidase. Coating polyphosphate–M23 phage endolysin nanoparticles (M23‐PP) with HAMS confers Staphylococcus aureus responsiveness.
Mariana Blanco Massani +11 more
wiley +1 more source
The TRPM8 protein is a testosterone receptor: II. Functional evidence for an ionotropic effect of testosterone on TRPM8. [PDF]
Asuthkar S +9 more
europepmc +1 more source
Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina [PDF]
PURPOSE: Kinetic studies of photoreceptor cell death in the retinal degeneration (rd1) mouse model suggest that photoreceptor degeneration could result from cumulative damage.
Delyfer, MN +5 more
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