Results 211 to 220 of about 55,204 (263)

Effects of Beer and Hop on Ionotropic γ-Aminobutyric Acid Receptors

Journal of Agricultural and Food Chemistry, 2006
Beer induced the response of the ionotropic gamma-aminobutyric acid receptors (GABA(A) receptors) expressed in Xenopus oocytes, indicating the presence of gamma-aminobutyric acid (GABA)-like activity. Furthermore, the pentane extract of the beer, hop (Humulus lupulus L.) oil, and myrcenol potentiated the GABA(A) receptor response elicited by GABA.
Hitoshi, Aoshima, Katsuichi, Takeda, Yoichi, Okita, Sheikh Julfikar, Hossain, Hirofumi, Koda, Yoshinobu, Kiso   +5 more
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Differential effects of chlorpromazine on ionotropic glutamate receptors in cultured rat hippocampal neurons

Neuroscience Letters, 2001
The effect of a widely used phenothiazine, chlorpromazine (CPZ) on ionotropic glutamate receptors was investigated using the patch-clamp technique in cultured rat hippocampal neurons. The non-N-methyl-D-aspartate (NMDA) receptors were insensitive to CPZ. The current responses to NMDA showed a wide range of variability of both the rate and the extent of
E D, Zarnowska, J W, Mozrzymas
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Effects of Prenatal Ethanol Exposure on Hippocampal Ionotropic‐Quisqualate and Kainate Receptors

Alcoholism: Clinical and Experimental Research, 1992
Previous studies from our laboratories have shown that the consumption of moderate quantities of ethanol by rat dams during pregnancy reduces N‐methyl‐d‐aspartate (NMDA) agonist receptor binding and NMDA‐mediated electrophysiological responses in the hippocampal formation of adult offspring.
D, Martin, D D, Savage, H S, Swartzwelder   +2 more
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Metabotropic and ionotropic glutamate receptors mediate opposite effects on periaqueductal gray matter

European Journal of Pharmacology, 1995
Microinjections, into the dorso-lateral periaqueductal gray matter, of N-methyl-D-aspartic acid (NMDA, 0.07-7 nmol/rat) significantly (P < 0.01) increased arterial blood pressure in a dose-related manner. Pretreatment, 5 min before NMDA (7 nmol/rat), in the same area with 2-amino-5-phosphonovaleric acid (2-APV, 5 nmol/rat), a selective antagonist of ...
LEYVA J, MAIONE, Sabatino, PALLOTTA M, BERRINO, Liberato, ROSSI F.   +4 more
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Differential effects of haloperidol and clozapine on ionotropic glutamate receptors in rats

Synapse, 1999
Despite multiple lines of investigation the effect of neuroleptics on glutamate-mediated neurotransmission remains controversial. To study the effects of typical and atypical neuroleptics on selected parameters of glutamate-mediated neurotransmission, male Sprague-Dawley rats were randomly assigned to a 21-day oral treatment course with vehicle ...
C F, Spurney, S M, Baca, A M, Murray, G E, Jaskiw, J E, Kleinman, T M, Hyde   +5 more
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Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain

Synapse, 2009
AbstractAsenapine, a new pyschopharmacologic agent being developed for the treatment of schizophrenia and bipolar disorder, has a unique human receptor binding signature with strong affinity for dopaminergic, α‐adrenergic, and, in particular, serotonergic receptors raising the possibility of interactions with glutamatergic receptors.
Frank I, Tarazi, Yong Kee, Choi, Matthew, Gardner, Erik H F, Wong, Brian, Henry, Mohammed, Shahid   +5 more
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Ionotropic Glutamate Receptor Biology: Effect on Synaptic Connectivity and Function in Neurological Disease

Current Medicinal Chemistry, 2003
Glutamate receptor signaling is essential to normal synaptic function in the central nervous system. The major ionotropic glutamate receptors (AMPA, Kainic, and NMDA) have different synaptic functions depending upon cellular and subcellular localization, subunit composition, and second messenger systems linked to the receptors.
G N, Barnes, J T, Slevin
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[Effects of ionotropic glutamate receptor channel blockers ON sleep-waking organization in rats].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2012
The effects of non-competitive glutamate receptor antagonists on sleep-waking organization have been studied on Krushinskii-Molodkina rats having an inherited predisposition to audiogenic seizures and Wistar ones which are resistant to this action of sound.
S I, Vataev, G A, Oganesian, V E, Gmiro, N Ia, Lukomskaia, L G, Magazanik   +4 more
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The effect of ionotropic gelation residence time on alginate cross-linking and properties

Carbohydrate Polymers, 2017
The ability to engineer biocompatible polymers with controllable properties is highly desirable. One such approach is to cross-link carbohydrate polymers using ionotropic gelation (IG). Previous studies have investigated the effect of curing time on alginate cross-linking. Herein, we discuss a novel study detailing the effect of IG residence time (IGRT)
Mitulkumar A. Patel, Mohamed H.H. AbouGhaly, Jacqueline V. Schryer-Praga, Keith Chadwick   +3 more
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Effects of nigrostriatal dopamine denervation on ionotropic glutamate receptors in rat caudate-putamen

Brain Research, 2000
Changes in ionotropic glutamate NMDA, AMPA and KA receptor binding in rat caudate-putamen were examined by quantitative in vitro receptor autoradiography 5 weeks after lesioning nigrostriatal dopaminergic projections. In this animal model of Parkinson's disease, density of binding in caudate-putamen increased at KA, but not NMDA or AMPA receptors.
F I, Tarazi, K, Zhang, R J, Baldessarini
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