Results 31 to 40 of about 55,204 (263)

Detrimental effects of soluble α-synuclein oligomers at excitatory glutamatergic synapses

Frontiers in Aging Neuroscience, 2023
IntroductionOligomeric and fibrillar species of the synaptic protein α-synuclein are established key players in the pathophysiology of Parkinson’s disease and other synucleinopathies. Increasing evidence in the literature points to prefibrillar oligomers
Elena Ferrari, Michela Salvadè, Elisa Zianni, Marta Brumana, Monica DiLuca, Fabrizio Gardoni   +5 more
doaj   +1 more source

Complex evolutionary dynamics of massively expanded chemosensory receptor families in an extreme generalist chelicerate herbivore [PDF]

, 2016
While mechanisms to detoxify plant produced, anti-herbivore compounds have been associated with plant host use by herbivores, less is known about the role of chemosensory perception in their life histories.
Bajda-Wybouw, Sabina, Cao, Thi Ngoc Phuong, Clark, Richard M, Dermauw, Wannes, Grbić, Miodrag, Greenhalgh, Robert, Rombauts, Stephane, Rouzé, Pierre, Van de Peer, Yves, Van Leeuwen, Thomas, Zhurov, Vladimir   +10 more
core   +4 more sources

Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]

, 2020
BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U., Byvaltcev, Egor, Döhne, Noah, Grosser, Sabine, Janach, Gabriel M. S., Reetz, Olivia, Stadler, Konstantin, Strauss, Ulf   +7 more
core   +1 more source

The Effects of Ionotropic GABA Receptor Blockage on the Brain in Rats with Induced Sepsis

Molecular Neurobiology, 2023
Abstract Encephalopathy develops following sepsis, which is defined as life-threatening organ failure due to the irregular response of a host to infection. It has high mortality and morbidity rates. In this study, we aimed to investigate the effects of inflammation on brain tissue, and the effects of the gamma-aminobutyric acid-A (GABAA ...
Gulten Ates, Elif Ozkok, Gul Ipek Gundogan, Sule Tamer   +3 more
openaire   +3 more sources

Nitric Oxide Orchestrates a Power-Law Modulation of Sympathetic Firing Behaviors in Neonatal Rat Spinal Cords

Frontiers in Physiology, 2018
Nitric oxide (NO) is a diffusible gas and has multifarious effects on both pre- and postsynaptic events. As a consequence of complex excitatory and inhibitory integrations, NO effects on neuronal activities are heterogeneous.
Chun-Kuei Su, Yi-Yin Chen, Chiu-Ming Ho
doaj   +1 more source

Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1β release by mononuclear phagocytes

Frontiers in Immunology, 2023
ObjectiveThe pro-inflammatory cytokine interleukin-1β (IL-1β) plays a central role in host defense against infections. High systemic IL-1β levels, however, promote the pathogenesis of inflammatory disorders.
Katrin Richter, Nilay Asci, Vijay K. Singh, Sanaria Hawro Yakoob, Marion Meixner, Anna Zakrzewicz, Juliane Liese, Andreas Hecker, Sigrid Wilker, Sabine Stumpf, Klaus-Dieter Schlüter, Marius Rohde, Axel Gödecke, Winfried Padberg, Ivan Manzini, Günther Schmalzing, Veronika Grau   +16 more
doaj   +1 more source

Cocaine modulates locomotion behavior in C. elegans.

PLoS ONE, 2009
Cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including DAT (dopamine transporter), SERT (serotonin transporter) and NET (norepinephrine transporter).
Alex Ward, Vyvyca J Walker, Zhaoyang Feng, X Z Shawn Xu   +3 more
doaj   +1 more source

Ionotropic glutamate receptors mediate inducible defense in the water flea Daphnia pulex. [PDF]

PLoS ONE, 2015
Phenotypic plasticity is the ability held in many organisms to produce different phenotypes with a given genome in response to environmental stimuli, such as temperature, nutrition and various biological interactions.
Hitoshi Miyakawa, Masanao Sato, John K Colbourne, Taisen Iguchi   +3 more
doaj   +1 more source

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

iScience, 2021
Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley   +8 more
doaj   +1 more source

Memantine Confers Multi-Target Protection in a Zebrafish Seizure Model: Attenuating Epileptic Behavior, GluN2A Overexpression, and Oxidative Stress. [PDF]

J Neurochem
Approximately 30% of epilepsy patients do not respond to current medications. In addition, the pharmaceutical industry is reducing its interest in de novo drug discovery for epilepsy. Drug repurposing offers a promising alternative. This study investigated memantine, an Alzheimer's drug, in a zebrafish model of seizures.
Zenki KC, Kalinine E, Mussulini BHM, Dos Santos TG, von Mengden L, Klamt F, Baggio S, de Moura AC, da Veiga ABG, de Oliveira DL.   +9 more
europepmc   +2 more sources