Results 201 to 210 of about 59,051 (256)
Some of the next articles are maybe not open access.
Purine Ionotropic (P2X) Receptors
Current Pharmaceutical Design, 2007Purinergic signaling is involved in the proper functioning of virtually all organs of the body. Although in some cases purines have a major influence on physiological functions (e.g. thrombocyte aggregation), more often they are just background modulators contributing to fine tuning of biological events.
L, Köles, S, Fürst, P, Illes
openaire +2 more sources
Ionotropic glutamate receptors
Current Opinion in Chemical Biology, 1999The glutamate-binding sites of ionotropic glutamate receptors are formed from two extracellular domains of a single subunit. Conformational changes induced by agonist binding produce mechanical processes that are translated into ion gating and receptor desensitization.
openaire +2 more sources
Presynaptic Ionotropic GABA Receptors
2007Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Andreas, Draguhn +2 more
openaire +2 more sources
Molecular Structure of Ionotropic Glutamate Receptors
Current Medicinal Chemistry, 2010L-glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Although just a few glutamate receptor ligands have turned out to be clinically useful, primarily because of unfavorable psychotropic side effects, the glutamate system remains an attractive molecular target in the treatment of epilepsy, neurodegenerative diseases
A A, Kaczor, D, Matosiuk
openaire +2 more sources
Ionotropic Glutamate Receptors
2013On this planet, the mammalian brain is probably the most complex cellular network. In this system, glutamate is the dominant neurotransmitter, and it mediates the fast communication between the units of the network. Glutamate's main sites of action are the ionotropic glutamate receptors (iGluRs) and G−protein−coupled metabotropic glutamate receptors ...
openaire +3 more sources
Avoiding cantharidin through ionotropic receptors
Journal of Hazardous MaterialsThe discernment and aversion of noxious gustatory stimuli profoundly influence homeostasis maintenance and survival of fauna. Cantharidin, a purported aphrodisiac, is a monoterpenoid compound secreted by many species of blister beetle, particularly by the Spanish fly, Lytta vesicatoria.
Roshani Nhuchhen, Pradhan +2 more
openaire +2 more sources
Modulation of Ionotropic Glutamate Receptor Channels
Neurochemical Research, 2001Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory.
L, Köles, K, Wirkner, P, Illes
openaire +2 more sources
Monoamine Transporters as Ionotropic Receptors
Trends in Neurosciences, 2017It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Given their capacity to generate fast-acting currents, I suggest that the monoamine transporters should be ...
openaire +2 more sources
Ionotropic Glutamate Receptors
1997Glutamate is the major mediator of fast excitatory transmission in the mammalian central nervous system (CNS). It plays an important role in processes controlling synaptic plasticity, memory formation, and learning. The release of excess glutamate and overexcitation are the causes of neuronal damage and cell death in pathological conditions, such as ...
openaire +1 more source