Results 211 to 220 of about 1,272,062 (259)

Molecular Structure of Ionotropic Glutamate Receptors

Current Medicinal Chemistry, 2010
L-glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Although just a few glutamate receptor ligands have turned out to be clinically useful, primarily because of unfavorable psychotropic side effects, the glutamate system remains an attractive molecular target in the treatment of epilepsy, neurodegenerative diseases
A A, Kaczor, D, Matosiuk
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Presynaptic Ionotropic GABA Receptors

2007
Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Andreas, Draguhn, Nikolai, Axmacher, Sergej, Kolbaev   +2 more
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Monoamine Transporters as Ionotropic Receptors

Trends in Neurosciences, 2017
It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Given their capacity to generate fast-acting currents, I suggest that the monoamine transporters should be ...
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The subunit arrangement and assembly of ionotropic receptors

Trends in Neurosciences, 2008
Ionotropic receptors mediate rapid communication between neurons. These receptors are oligomers and are usually assembled from multiple subunit types. Receptors built from different subunit combinations have distinct functional properties, such as single-channel conductances, rates of desensitization and sensitivities to activators and inactivators ...
Nelson P, Barrera, J Michael, Edwardson
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Regulation of ionotropic receptors by protein phosphorylation

Biochemical Pharmacology, 1996
The regulation of synaptic signal transduction is of central importance to our understanding of normal and abnormal nervous system function. One mechanism by which signal transduction can be affected is the modification of cellular sensitivity by alterations of transmembrane receptor properties.
B A, Pasqualotto, C A, Shaw
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Structural dynamics of an ionotropic glutamate receptor

Proteins: Structure, Function, and Bioinformatics, 2004
AbstractIonotropic glutamate receptors (iGluRs) are postsynaptic ion channels involved in excitatory neurotransmission. iGluRs play important roles in development and in forms of synaptic plasticity that underlie higher order processes such as learning and memory. Neurobiological and biochemical studies have long characterized iGluRs in detail. However,
Minoru, Kubo, Etsuro, Ito
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Ionotropic Glutamate Receptors

2013
On this planet, the mammalian brain is probably the most complex cellular network. In this system, glutamate is the dominant neurotransmitter, and it mediates the fast communication between the units of the network. Glutamate's main sites of action are the ionotropic glutamate receptors (iGluRs) and G−protein−coupled metabotropic glutamate receptors ...
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Ionotropic Glutamate Receptors

1997
Glutamate is the major mediator of fast excitatory transmission in the mammalian central nervous system (CNS). It plays an important role in processes controlling synaptic plasticity, memory formation, and learning. The release of excess glutamate and overexcitation are the causes of neuronal damage and cell death in pathological conditions, such as ...
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Avoiding cantharidin through ionotropic receptors

Journal of Hazardous Materials
The discernment and aversion of noxious gustatory stimuli profoundly influence homeostasis maintenance and survival of fauna. Cantharidin, a purported aphrodisiac, is a monoterpenoid compound secreted by many species of blister beetle, particularly by the Spanish fly, Lytta vesicatoria.
Pradhan, Roshani Nhuchhen, Shrestha, Bhanu, Lee, Youngseok   +2 more
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Genetic Variations of Ionotropic Glutamate Receptor Pathways on Interferon-α-induced Depression in Patients with Hepatitis C Viral Infection

Brain, Behavior, and Immunity, 2021
Jane Pei-Chen Chang, Kuan-Pin Su, Sergey Shityakov   +2 more
exaly