Structural basis of odorant recognition by a human odorant receptor [PDF]
Nature, 2023 Abstract Our sense of smell enables us to navigate a vast space of chemically diverse odor molecules. This task is accomplished by the combinatorial activation of approximately 400 olfactory G protein-coupled receptors (GPCRs) encoded in the human genome 1–3 .
Claire A De March +2 more
exaly +8 more sources
Genetic and functional odorant receptor variation in the Homo lineage [PDF]
iScience, 2023 Summary: Humans, Neanderthals, and Denisovans independently adapted to a wide range of geographic environments and their associated food odors. Using ancient DNA sequences, we explored the in vitro function of thirty odorant receptor genes in the genus ...
Claire A. de March +4 more
doaj +4 more sources
Structural basis of the sweat odorant HMHA recognition by the human odorant receptor OR52E8 [PDF]
Communications Biology3-Hydroxy-3-methyl hexanoic acid (HMHA), a key component of human axillary sweat, specifically activates the human odorant receptor OR52E8. However, the molecular basis of this recognition remains elusive.
Chulwon Choi +5 more
doaj +2 more sources
How Far Does a Receptor Influence Vibrational Properties of an Odorant? [PDF]
PLoS ONE, 2016 The biophysical mechanism of the sense of smell, or olfaction, is still highly debated. The mainstream explanation argues for a shape-based recognition of odorant molecules by olfactory receptors, while recent investigations suggest the primary olfactory
Anna Reese +3 more
doaj +3 more sources
Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels [PDF]
Communications BiologyInsects have a powerful olfactory system that is far more selective and sensitive than artificial detectors. Insect odorant receptors (ORs) are key components of the system, which are ligand-gated ion channels comprising a specific odorant-sensing OR and
Wei Xue +7 more
doaj +2 more sources
Elucidation of the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors [PDF]
Nature Communications, 2023 In numerous insects, the olfactory receptor family forms a unique class of heteromeric cation channels. Recent progress in resolving the odorant receptor structures offers unprecedented opportunities for deciphering their molecular mechanisms of ligand ...
Jody Pacalon +6 more
doaj +2 more sources
First Contact to Odors: Our Current Knowledge about Odorant Receptor
Sensors, 2008 Chemical senses – especially smell – are known to be important for the fundamental life events such as sensing predators, selecting mates, as well as finding food.
Cheil Moon +4 more
doaj +3 more sources
Diversity and Molecular Evolution of Odorant Receptor in Hemipteran Insects [PDF]
Insects, 2022 Youssef Dewer +2 more
exaly +2 more sources
Annotation and Analysis of 3902 Odorant Receptor Protein Sequences from 21 Insect Species Provide Insights into the Evolution of Odorant Receptor Gene Families in Solitary and Social Insects [PDF]
Genes, 2022 MIGUEL Andrade +2 more
exaly +2 more sources
Odor sampling strategies in mice with genetically altered olfactory responses.
PLoS ONE, 2021 Peripheral sensory cells and the central neuronal circuits that monitor environmental changes to drive behaviors should be adapted to match the behaviorally relevant kinetics of incoming stimuli, be it the detection of sound frequencies, the speed of ...
Johannes Reisert +3 more
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