OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant-receptor interactions. [PDF]
Nucleic Acids Res, 2022 Olfaction is a multi-stage process that initiates with the odorants entering the nose and terminates with the brain recognizing the odor associated with the odorant.
Sharma A, Saha BK, Kumar R, Varadwaj PK.
europepmc +5 more sources
Odorant Receptor Desensitization in Insects [PDF]
Journal of Experimental Neuroscience, 2017 Insects and other arthropods transmit devastating human diseases, and these vectors use chemical senses to target humans. Understanding how these animals detect, respond, and adapt to volatile odorants may lead to novel ways to disrupt host localization ...
Hao Guo, Dean P Smith
doaj +4 more sources
Advantage of the Highly Restricted Odorant Receptor Expression Pattern in Chemosensory Neurons of Drosophila. [PDF]
PLoS ONE, 2013 A fundamental molecular feature of olfactory systems is that individual neurons express only one receptor from a large odorant receptor gene family. While numerous theories have been proposed, the functional significance and evolutionary advantage of ...
Sana Khalid Tharadra +2 more
doaj +4 more sources
Odorant Receptor Inhibition is Fundamental to Odor Encoding [PDF]
Current Biology, 2019 Most natural odors are complex mixtures of many volatile components, competing to bind odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose.
Patrick Pfister +12 more
semanticscholar +4 more sources
Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes [PDF]
BMC Neuroscience, 2007 The olfactory system meets niche- and species-specific demands by an accelerated evolution of its odorant receptor repertoires. In this review, we describe evolutionary processes that have shaped olfactory and vomeronasal receptor gene families in ...
Lane Robert P, Kambere Marijo B
doaj +4 more sources
How Far Does a Receptor Influence Vibrational Properties of an Odorant? [PDF]
PLoS ONE, 2016 The biophysical mechanism of the sense of smell, or olfaction, is still highly debated. The mainstream explanation argues for a shape-based recognition of odorant molecules by olfactory receptors, while recent investigations suggest the primary olfactory
Anna Reese +3 more
doaj +6 more sources
Genetic and functional odorant receptor variation in the Homo lineage. [PDF]
iScience, 2023 Summary: Humans, Neanderthals, and Denisovans independently adapted to a wide range of geographic environments and their associated food odors. Using ancient DNA sequences, we explored the in vitro function of thirty odorant receptor genes in the genus ...
de March CA +4 more
europepmc +2 more sources
Odorant Receptor 7D4 Activation Dynamics. [PDF]
Angewandte Chemie, 2018 AbstractDeciphering how an odorant activates an odorant receptor (OR) and how changes in specific OR residues affect its responsiveness are central to understanding our sense of smell. A joint approach combining site‐directed mutagenesis and functional assays with computational modeling has been used to explore the signaling mechanics of OR7D4. In this
Claire A. de March +6 more
semanticscholar +4 more sources
Odorant and pheromone receptors in insects [PDF]
Frontiers in Cellular Neuroscience, 2009 Since the emergence of the first living cells, survival has hinged on the ability to detect and localize chemicals in the environment. Modern animal species ranging from insects to mammals express large odorant receptor repertoires to detect the ...
TAL S HA, Dean p Smith
doaj +3 more sources
Structural basis of odorant recognition by a human odorant receptor. [PDF]
Nature, 2023 Billesbølle CB +10 more
europepmc +2 more sources