Results 1 to 10 of about 2,668,755 (284)

Predicting olfactory receptor neuron responses from odorant structure

, 2007
Background Olfactory receptors work at the interface between the chemical world of volatile molecules and the perception of scent in the brain. Their main purpose is to translate chemical space into information that can be processed by neural circuits ...
De Bruyne, Marien, de Bruyne Marien, Melanie Hähnel (16193975), Marien de Bruyne (170456), Hähnel, Melanie, Michael Schmuker (4736406), Schmuker Michael, Schneider, Gisbert (Prof. Dr.), Schmuker, Michael, Gisbert Schneider (17096), Hähnel Melanie, Schneider Gisbert   +11 more
core   +1 more source

Bcl11b controls odorant receptor class choice in mice

Communications Biology, 2019
Each olfactory sensory neuron (OSN) expresses a single odorant receptor (OR) gene from the class I or class II repertoire in mice. The mechanisms that regulate OR class choice in OSNs remain unknown.
Takayuki Enomoto, Hidefumi Nishida, Tetsuo Iwata, Akito Fujita, Kanako Nakayama, Takahiro Kashiwagi, Yasue Hatanaka, Hiro Kondo, Rei Kajitani, T. Itoh, Makoto Ohmoto, I. Matsumoto, J. Hirota   +12 more
semanticscholar   +1 more source

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit

Scientific Reports, 2019
Olfaction is a key component of the multimodal approach used by mosquitoes to target and feed on humans, spreading various diseases. Current repellents have drawbacks, necessitating development of more effective agents.
Devin Kepchia, Pingxi Xu, Raymond Terryn, Ana Castro, S. Schürer, W. Leal, C. Luetje   +6 more
semanticscholar   +1 more source

Kinetics of Odorant Recognition with a Graphene-Based Olfactory Receptor Mimicry

Chemosensors, 2022
Malaria vector mosquito species rely on a handful of specific pheromones for mating; one of them, sulcatone (6-methyl-5-hepten-2-one), is also found in human exudation.
Caroline Bonazza, Klaus Bonazza
doaj   +1 more source

Evolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophila [PDF]

, 2008
Background. Gene families typically evolve by gene duplication followed by the adoption of new or altered gene functions. A different way to evolve new but related functions is alternative splicing of existing exons of a complex gene.
Butlin, Roger K., Gardiner, Anastasia, Gardiner, A., Jordan, W.C., Ritchie Michael G., Ritchie, M.G., Jordan, William C., Michael G Ritchie, Barker, Daniel, William C Jordan, Barker, D., Ritchie, Michael G., Gardiner Anastasia, Daniel Barker, Anastasia Gardiner, Barker Daniel, Roger K Butlin, Jordan William C., Butlin, R.K., Butlin Roger K.   +19 more
core   +1 more source

Genetic elucidation of human hyperosmia to isovaleric acid.

PLoS Biology, 2007
The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown.
Idan Menashe, Tatjana Abaffy, Yehudit Hasin, Sivan Goshen, Vered Yahalom, Charles W Luetje, Doron Lancet   +6 more
doaj   +1 more source

Detection of Odorant Molecules in the Gaseous Phase Using α-, β-, and γ-Cyclodextrin Films on a Quartz Crystal Microbalance

Technologies, 2018
There is an interest in sensors for the detection of odorant molecules in the gaseous phase, especially those related to the fragrance of fruits, because odorant sensing is useful for on-site quality control of agricultural products.
Kai Sasaki, Hiroyuki Furusawa, Kuniaki Nagamine, Shizuo Tokito   +3 more
doaj   +1 more source

A long-range cis-regulatory element for class I odorant receptor genes

Nature Communications, 2017
Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes.
Tetsuo Iwata, Y. Niimura, Chizuru Kobayashi, Daichi Shirakawa, Hikoyu Suzuki, Takayuki Enomoto, K. Touhara, Y. Yoshihara, J. Hirota   +8 more
semanticscholar   +1 more source

Role of the odorant receptor in neuronal connectivity in the olfactory bulb

Swiss Medical Weekly, 2015
Olfaction is a highly sophisticated sensory modality able to detect and discriminate thousands of different odours, even at very low concentration. How such a challenging task is achieved remains to be fully understood.
Nelly Redolfi, Claudia Lodovichi
doaj   +1 more source

Olfactory discrimination largely persists in mice with defects in odorant receptor expression and axon guidance

Neural Development, 2012
Background The defining feature of the main olfactory system in mice is that each olfactory sensory neuron expresses only one of more than a thousand different odorant receptor genes.
Knott Thomas K, Madany Pasil A, Faden Ashley A, Xu Mei, Strotmann Jörg, Henion Timothy R, Schwarting Gerald A   +6 more
doaj   +1 more source