Structural basis of odorant recognition by a human odorant receptor [PDF]
Nature, 2023 Our sense of smell enables us to navigate a vast space of chemically diverse odour molecules. This task is accomplished by the combinatorial activation of approximately 400 odorant G protein-coupled receptors encoded in the human genome1-3.
Claire A de March +2 more
exaly +4 more sources
A conserved aspartic acid is important for agonist (VUAA1) and odorant/tuning receptor-dependent activation of the insect odorant co-receptor (Orco). [PDF]
PLoS ONE, 2013 Insect odorant receptors function as heteromeric odorant-gated cation channels comprising a conventional odorant-sensitive tuning receptor, and a conserved co-receptor (Orco).
Brijesh N Kumar +5 more
doaj +2 more sources
How Far Does a Receptor Influence Vibrational Properties of an Odorant? [PDF]
PLoS ONE, 2016 The biophysical mechanism of the sense of smell, or olfaction, is still highly debated. The mainstream explanation argues for a shape-based recognition of odorant molecules by olfactory receptors, while recent investigations suggest the primary olfactory
Anna Reese +3 more
doaj +3 more sources
Structural basis of the sweat odorant HMHA recognition by the human odorant receptor OR52E8 [PDF]
Communications Biology3-Hydroxy-3-methyl hexanoic acid (HMHA), a key component of human axillary sweat, specifically activates the human odorant receptor OR52E8. However, the molecular basis of this recognition remains elusive.
Chulwon Choi +5 more
doaj +2 more sources
Genetic and functional odorant receptor variation in the Homo lineage [PDF]
iScience, 2023 Summary: Humans, Neanderthals, and Denisovans independently adapted to a wide range of geographic environments and their associated food odors. Using ancient DNA sequences, we explored the in vitro function of thirty odorant receptor genes in the genus ...
Claire A. de March +4 more
doaj +2 more sources
The Mouse Solitary Odorant Receptor Gene Promoters as Models for the Study of Odorant Receptor Gene Choice. [PDF]
PLoS ONE, 2016 BACKGROUND:In vertebrates, several anatomical regions located within the nasal cavity mediate olfaction. Among these, the main olfactory epithelium detects most conventional odorants.
Andrea Degl'Innocenti +3 more
doaj +3 more sources
Identification of odorant-receptor interactions by global mapping of the human odorome. [PDF]
PLoS ONE, 2014 The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors (hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant ...
Karine Audouze +7 more
doaj +2 more sources
Mammalian odorant receptor tuning breadth persists across distinct odorant panels. [PDF]
PLoS ONE, 2017 The molecular receptive range (MRR) of a mammalian odorant receptor (OR) is the set of odorant structures that activate the OR, while the distribution of these odorant structures across odor space is the tuning breadth of the OR.
Devin Kepchia +3 more
doaj +2 more sources
Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels [PDF]
Communications BiologyInsects have a powerful olfactory system that is far more selective and sensitive than artificial detectors. Insect odorant receptors (ORs) are key components of the system, which are ligand-gated ion channels comprising a specific odorant-sensing OR and
Wei Xue +7 more
doaj +2 more sources
Elucidation of the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors [PDF]
Nature Communications, 2023 In numerous insects, the olfactory receptor family forms a unique class of heteromeric cation channels. Recent progress in resolving the odorant receptor structures offers unprecedented opportunities for deciphering their molecular mechanisms of ligand ...
Jody Pacalon +6 more
doaj +2 more sources