Structural basis of odorant recognition by a human odorant receptor [PDF]
Nature, 2023 Our sense of smell enables us to navigate a vast space of chemically diverse odour molecules. This task is accomplished by the combinatorial activation of approximately 400 odorant G protein-coupled receptors encoded in the human genome^ 1 – 3 .
Christian B Billesbølle +2 more
exaly +9 more sources
Odorant Receptor Desensitization in Insects [PDF]
Journal of Experimental Neuroscience, 2017 Insects and other arthropods transmit devastating human diseases, and these vectors use chemical senses to target humans. Understanding how these animals detect, respond, and adapt to volatile odorants may lead to novel ways to disrupt host localization ...
Hao Guo, Dean P Smith
doaj +5 more sources
OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant-receptor interactions. [PDF]
Nucleic Acids Res, 2022 Olfaction is a multi-stage process that initiates with the odorants entering the nose and terminates with the brain recognizing the odor associated with the odorant.
Sharma A, Saha BK, Kumar R, Varadwaj PK.
europepmc +5 more sources
Genetic and functional odorant receptor variation in the Homo lineage [PDF]
iScience, 2023 Summary: Humans, Neanderthals, and Denisovans independently adapted to a wide range of geographic environments and their associated food odors. Using ancient DNA sequences, we explored the in vitro function of thirty odorant receptor genes in the genus ...
Claire A. de March +4 more
doaj +4 more sources
Regulatory Features for Odorant Receptor Genes in the Mouse Genome
Frontiers in Genetics, 2017 The odorant receptor genes, seven transmembrane receptor genes constituting the vastest mammalian gene multifamily, are expressed monogenically and monoallelicaly in each sensory neuron in the olfactory epithelium.
A. Degl'Innocenti, A. D'Errico
exaly +3 more sources
Ectopic Odorant Receptor Responding to Flavor Compounds: Versatile Roles in Health and Disease
Pharmaceutics, 2021 Prompted by the ground-breaking discovery of the rodent odorant receptor (OR) gene family within the olfactory epithelium nearly 30 years ago, followed by that of OR genes in cells of the mammalian germ line, and potentiated by the identification of ORs ...
Tao Tong, Yanan Wang, Seong-Gook Kang
exaly +2 more sources
The Mouse Solitary Odorant Receptor Gene Promoters as Models for the Study of Odorant Receptor Gene Choice. [PDF]
PLoS ONE, 2016 BACKGROUND:In vertebrates, several anatomical regions located within the nasal cavity mediate olfaction. Among these, the main olfactory epithelium detects most conventional odorants.
Andrea Degl'Innocenti +3 more
doaj +3 more sources
Odorant Receptor Inhibition is Fundamental to Odor Encoding [PDF]
Current Biology, 2019 Most natural odors are complex mixtures of many volatile components, competing to bind odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose.
Patrick Pfister +12 more
semanticscholar +4 more sources
Odorant and pheromone receptors in insects [PDF]
Frontiers in Cellular Neuroscience, 2009 Since the emergence of the first living cells, survival has hinged on the ability to detect and localize chemicals in the environment. Modern animal species ranging from insects to mammals express large odorant receptor repertoires to detect the ...
TAL S HA, Dean p Smith
doaj +3 more sources
A conserved aspartic acid is important for agonist (VUAA1) and odorant/tuning receptor-dependent activation of the insect odorant co-receptor (Orco). [PDF]
PLoS ONE, 2013 Insect odorant receptors function as heteromeric odorant-gated cation channels comprising a conventional odorant-sensitive tuning receptor, and a conserved co-receptor (Orco).
Brijesh N Kumar +5 more
doaj +2 more sources