Results 141 to 150 of about 33,342 (190)

Candidate chemosensory ionotropic receptors in a Lepidoptera

Insect Molecular Biology, 2010
Abstract A new family of candidate chemosensory ionotropic receptors (IRs) related to ionotropic glutamate receptors (iGluRs) was recently discovered in Drosophila melanogaster .
Olivier, Violaine, Monsempes, Christelle, François, Marie-Christine, Poivet, Erwan, Joly, Emmanuelle   +4 more
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Presynaptic Ionotropic GABA Receptors

2007
Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Andreas, Draguhn, Nikolai, Axmacher, Sergej, Kolbaev   +2 more
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Glycine agonism in ionotropic glutamate receptors

Neuropharmacology, 2021
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the vertebrate CNS. Classified as AMPA, kainate, delta and NMDA receptors, iGluRs are central drivers of synaptic plasticity widely considered as a major cellular substrate of learning and memory. Surprisingly however, five
Stroebel, David, Mony, Laetitia, Paoletti, Pierre   +2 more
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Molecular Structure of Ionotropic Glutamate Receptors

Current Medicinal Chemistry, 2010
L-glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Although just a few glutamate receptor ligands have turned out to be clinically useful, primarily because of unfavorable psychotropic side effects, the glutamate system remains an attractive molecular target in the treatment of epilepsy, neurodegenerative diseases
A A, Kaczor, D, Matosiuk
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Monoamine Transporters as Ionotropic Receptors

Trends in Neurosciences, 2017
It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Given their capacity to generate fast-acting currents, I suggest that the monoamine transporters should be ...
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The subunit arrangement and assembly of ionotropic receptors

Trends in Neurosciences, 2008
Ionotropic receptors mediate rapid communication between neurons. These receptors are oligomers and are usually assembled from multiple subunit types. Receptors built from different subunit combinations have distinct functional properties, such as single-channel conductances, rates of desensitization and sensitivities to activators and inactivators ...
Nelson P, Barrera, J Michael, Edwardson
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Ionotropic Glutamate Receptors

2013
On this planet, the mammalian brain is probably the most complex cellular network. In this system, glutamate is the dominant neurotransmitter, and it mediates the fast communication between the units of the network. Glutamate's main sites of action are the ionotropic glutamate receptors (iGluRs) and G−protein−coupled metabotropic glutamate receptors ...
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Modulation of Ionotropic Glutamate Receptor Channels

Neurochemical Research, 2001
Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory.
L, Köles, K, Wirkner, P, Illes
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Regulation of ionotropic receptors by protein phosphorylation

Biochemical Pharmacology, 1996
The regulation of synaptic signal transduction is of central importance to our understanding of normal and abnormal nervous system function. One mechanism by which signal transduction can be affected is the modification of cellular sensitivity by alterations of transmembrane receptor properties.
B A, Pasqualotto, C A, Shaw
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Structural dynamics of an ionotropic glutamate receptor

Proteins: Structure, Function, and Bioinformatics, 2004
AbstractIonotropic glutamate receptors (iGluRs) are postsynaptic ion channels involved in excitatory neurotransmission. iGluRs play important roles in development and in forms of synaptic plasticity that underlie higher order processes such as learning and memory. Neurobiological and biochemical studies have long characterized iGluRs in detail. However,
Minoru, Kubo, Etsuro, Ito
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