Results 41 to 50 of about 56,018 (149)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol

Frontiers in Neuroscience
Despite the proven efficacy of vagus nerve stimulation (VNS) in seizure control, its precise mechanism of action remains unclear. VNS is known to impact the cardiorespiratory system.
Javier Chávez Cerda, Elena Acedo Reina, Ayse S. Dereli, Louis Vande Perre, Romain Raffoul, Maxime Verstraeten, Michel-Antony Ngan Yamb, Enrique Germany Morrison, Elise Collard, Auriane Apaire, Pascal Doguet, Jérôme Garnier, Jean Delbeke, Riëm El Tahry, Antoine Nonclercq   +14 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Spectroscopy of low-phonon-energy Er:La2O2S oxysulfide [PDF]

EPJ Web of Conferences
Lanthanum oxysulfide powders doped with Erbium ions were fabricated by the combustion method followed by sulfurization at 1000 °C under H2S + N2 atmosphere. X-ray diffraction confirms their single-phase nature (sp. gr. P-3m1).
Poitou Marine, Normani Simone, Loiko Pavel, Braud Alain, Camy Patrice, Merdrignac-Conanec Odile   +5 more
doaj   +1 more source

Indoor particulate concentration during biomass burning in central India [PDF]

Journal of Advances in Environmental Health Research, 2017
Indoor air particulate (PM) exposure is several folds more dangerous than  outdoor air  owing to burning of different materials. Burning biomass emits toxic fumes that are found to be associated with  numerous health problems  such as respiratory ...
Rameshwari Verma, Khageshwar Patel, Santosh Verma, Eduardo Funes, Xiujian Zhao   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Vagal nerve signals are modulated by spontaneous seizures in Genetic Absence Epilepsy Rats from Strasbourg

Frontiers in Neuroscience
IntroductionOne-third of epileptic patients are resistant to conventional treatments. Vagus nerve stimulation is a promising therapy, especially when applied early during seizure onset.
Elise Collard, Enrique Germany Morrison, Enrique Germany Morrison, Elena Acedo Reina, Ayse S. Dereli, Auriane Apaire, Auriane Apaire, Antoine Nonclercq, Riem El Tahry, Riem El Tahry, Riem El Tahry   +10 more
doaj   +1 more source

Inhomogeneous spectral line broadening and site distribution in “mixed” Er:(Sc,Y)2O3 laser ceramics [PDF]

EPJ Web of Conferences
Erbium-doped “mixed” yttria-scandia (ScxY1-x)2O3 transparent laser ceramics were fabricated by vacuum sintering at 1750 °C from laser-ablated nanoparticles. Their absorption and mid-infrared emission properties were studied.
Normani Simone, Loiko Pavel, Maksimov Roman, Shitov Vladislav, Osipov Vladimir, Braud Alain, Camy Patrice   +6 more
doaj   +1 more source

Thermodynamic metal melting bases. Foundry production and metallurgy

Литьë и металлургия, 2020
Based on thermodynamic calculations, it is shown that metal melting is an equilibrium process that occurs at a constant temperature. In melting, microcrystals mainly disintegrate into nanocrystals.
E. I. Marukovich, V. Yu. Stetsenko
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source