Results 61 to 70 of about 4,244,479 (353)

Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse model

Acta Neuropathologica Communications
The connection between aging and neurodegenerative pathologies like Alzheimer’s disease (AD) has long been recognized, with senescent brain cells building up in the brains of AD patients.
Debora Palomares, Axelle A. T. Vanparys, Joana Jorgji, Esther Paître, Pascal Kienlen-Campard, Nuria Suelves   +5 more
doaj   +1 more source

Therapy onset and characteristics associated with improvement following HABIT-ILE in infants with unilateral cerebral palsy: secondary analysis of a randomized controlled trial

Frontiers in Neurology
AimTo explore the association between therapy onset and changes in motor and functional outcomes and identify characteristics associated with greater changes in infants with unilateral cerebral palsy (UCP) following Hand-Arm Bimanual Intensive Therapy ...
Astrid Carton de Tournai, Enimie Herman, Daniela Ebner-Karestinos, Daniela Ebner-Karestinos, Estelle Gathy, Estelle Gathy, Estelle Gathy, Rodrigo Araneda, Rodrigo Araneda, Anne Renders, Célia De Clerck, Seyma Kilcioglu, Yves Vandermeeren, Yves Vandermeeren, Yves Vandermeeren, Yannick Bleyenheuft, Yannick Bleyenheuft   +16 more
doaj   +1 more source

Variability of the Chemical Composition of the Atmospheric Aerosol in the Coastal Zone of the Southern Basin of Lake Baikal (East Siberia, Russia)

Atmosphere, 2022
The role of the atmosphere in the formation of the chemical composition and quality of water in Lake Baikal and its tributaries has been increasing in recent years. In this regard, studies of the chemical composition of the constituents of the atmosphere
Liudmila P. Golobokova, Tamara V. Khodzher, Galina S. Zhamsueva, Alexander S. Zayakhanov, Alexey Starikov, Olga I. Khuriganova   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Neural representation of the musical beat is facilitated but not contingent on the repetition of rhythmic patterns

Scientific Reports
Music often entails perception of periodic beats which serve as internal temporal references to coordinate movements to music. Crucially, beat perception arises even in syncopated musical rhythms, which only weakly cue the beat periodicity.
Emmanuel Coulon, Sacha Baum, Tomas Lenc, Rainer Polak, Sylvie Nozaradan   +4 more
doaj   +1 more source

Orange Sm:LiYF4 lasers emitting at 605 nm [PDF]

EPJ Web of Conferences
We report on polarized spectroscopy and orange laser operation under 2ω-OPSL and GaN-diode pumping of Sm:LiYF4 crystals. The Samarium laser delivers 12 mW at 605 nm with a threshold of 51 mW and a linear polarization.
Demaimay Jonathan, Loiko Pavel, Kifle Esrom, Pau Florence, Recoque Gilles, Benayad Abdelmjid, Georges Thierry, Camy Patrice, Braud Alain   +8 more
doaj   +1 more source

Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies

Nature Communications, 2023
Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies.
Nathalie Kyalu Ngoie Zola, Clémence Balty, Sébastien Pyr dit Ruys, Axelle A. T. Vanparys, Nicolas D. G. Huyghe, Gaëtan Herinckx, Manuel Johanns, Emilien Boyer, Pascal Kienlen-Campard, Mark H. Rider, Didier Vertommen, Bernard J. Hanseeuw   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gazing into spatiotemporal ‘known unknowns’: the influence of uncertainty on pupil size and saccadic eye movements

Scientific Reports
Expectation of a future stimulus increases the preparedness to act once it actually appears and results in reduced latency of the appropriate motor response.
Aïcha Boutachkourt, Dominika Drążyk, Marcus Missal   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source