Results 61 to 70 of about 2,790,786 (295)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2001 This short paper is an attempt to describe a theorist's view of the goals of relativistic heavy ion program which has just entered the collider era. These goals are centered around understanding the properties and the critical behavior of Quantum Chromo ...
Kharzeev, D.
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Preparation of Amidoxime Polyacrylonitrile Chelating Nanofibers and Their Application for Adsorption of Metal Ions. [PDF]
, 2013 Polyacrylonitrile (PAN) nanofibers were prepared by electrospinning and they were modified with hydroxylamine to synthesize amidoxime polyacrylonitrile (AOPAN) chelating nanofibers, which were applied to adsorb copper and iron ions. The conversion of the
Hsieh, You-Lo +5 more
core +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Precision spectroscopy with two correlated atoms
, 2007 We discuss techniques that allow for long coherence times in laser spectroscopy experiments with two trapped ions. We show that for this purpose not only entangled ions prepared in decoherence-free subspaces can be used but also a pair of ions that are ...
C. Sur +27 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Frontiers in NeuroscienceDespite the proven efficacy of vagus nerve stimulation (VNS) in seizure control, its precise mechanism of action remains unclear. VNS is known to impact the cardiorespiratory system.
Javier Chávez Cerda +14 more
doaj +1 more source
Sympathetic cooling of $^4$He$^+$ ions in a radiofrequency trap
, 2004 We have generated Coulomb crystals of ultracold $^4$He$^+$ ions in a linear radiofrequency trap, by sympathetic cooling via laser--cooled $^9$Be$^+$. Stable crystals containing up to 150 localized He$^+$ ions at $\sim$20 mK were obtained.
B. Roth +4 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source