Results 61 to 70 of about 1,421,795 (306)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Unusual fragmentation of 1,1,2,2,3,3-hexamethylindan. Methyl group equilibration and multi-step skeletal rearrangements in the [M - CH3]+ ions prior to the formation of t-C4H9+ and other fragment ions [PDF]
, 1992 Kuck D, Mehdizadeh A. Unusual fragmentation of 1,1,2,2,3,3-hexamethylindan. Methyl group equilibration and multi-step skeletal rearrangements in the [M - CH3]+ ions prior to the formation of t-C4H9+ and other fragment ions.
Kuck, Dietmar, Mehdizadeh, Ahmad
core +1 more source
Neural substrates underlying motor skill learning in chronic hemiparetic stroke patients
Frontiers in Human Neuroscience, 2015 Motor skill learning is critical in post-stroke motor recovery, but little is known about its underlying neural substrates. Recently, using a new visuomotor skill learning paradigm involving a speed/accuracy trade-off in healthy individuals we identified
Stephanie eLefebvre +13 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Solvolyses of diarylmethyl chlorides. A comprehensive stability scale for diarylcarbenium ions [PDF]
, 1988 Eleven donor substituted diarylmethyl chlorides have been solvolyzed in ethanol. The rate constants, determined at 25°C, and additional ethanolysis data taken from the literature have been connected with solvolvsis rate constants, determined in other ...
Schade, Christian +3 more
core +1 more source
Mid-infrared emissions of Dy3+ ions in CaF2 [PDF]
EPJ Web of ConferencesWe report on a comprehensive spectroscopic study of singly Dy3+ doped and Er3+,Dy3+ codoped calcium fluoride (CaF2) crystals for mid- infrared laser applications. The f-f transition probabilities of Dy3+ were determined by the Judd-Ofelt theory.
Nguyen Ngoc Quynh Hoa +7 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Metal Ions in Bio-Imaging Techniques Metal Ions in Life Sciences Ser.
, 2021 Description based upon print version of record.Includes bibliographical references and index.Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between ...
Sigel Roland K. O. +2 more
core
Frontiers in NeuroscienceDespite the proven efficacy of vagus nerve stimulation (VNS) in seizure control, its precise mechanism of action remains unclear. VNS is known to impact the cardiorespiratory system.
Javier Chávez Cerda +14 more
doaj +1 more source