Results 71 to 80 of about 1,421,795 (306)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Dimethyl sulfoxide solvates of the aluminium(III), gallium(III) and indium(III) ions. A crystallographic, EXAFS and vibrational spectroscopic study [PDF]

, 2003
The isostructural hexakis( dimethyl sulfoxide)-aluminium(III), -gallium(III) and -indium(III) iodides crystallise in the trigonal space group R(3) over bar ( no. 148), Z = 3, at 295 +/- 1 K.
Kritikos, M., Skripkin, M., Mink, János, Molla-Abbassi, A.   +3 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Formation of nitriles and isonitriles by the heavy-ion irradiation of propionitrile in N2-rich astrophysical ices

Astronomy & Astrophysics
Context. Nitriles are key nitrogen-bearing organic molecules in dense clouds, star-forming regions, and nitrogen-rich icy environments. Understanding their stability and chemical evolution under energetic processing is essential for understanding the ...
de Barros A. L. F., Dubois D., Sreeja R., Nguyen Trung T., Sbera T., Rothard H., Domaracka A.   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Vagal nerve signals are modulated by spontaneous seizures in Genetic Absence Epilepsy Rats from Strasbourg

Frontiers in Neuroscience
IntroductionOne-third of epileptic patients are resistant to conventional treatments. Vagus nerve stimulation is a promising therapy, especially when applied early during seizure onset.
Elise Collard, Enrique Germany Morrison, Enrique Germany Morrison, Elena Acedo Reina, Ayse S. Dereli, Auriane Apaire, Auriane Apaire, Antoine Nonclercq, Riem El Tahry, Riem El Tahry, Riem El Tahry   +10 more
doaj   +1 more source

Thermodynamic metal melting bases. Foundry production and metallurgy

Литьë и металлургия, 2020
Based on thermodynamic calculations, it is shown that metal melting is an equilibrium process that occurs at a constant temperature. In melting, microcrystals mainly disintegrate into nanocrystals.
E. I. Marukovich, V. Yu. Stetsenko
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Spectroscopy of low-phonon-energy Er:La2O2S oxysulfide [PDF]

EPJ Web of Conferences
Lanthanum oxysulfide powders doped with Erbium ions were fabricated by the combustion method followed by sulfurization at 1000 °C under H2S + N2 atmosphere. X-ray diffraction confirms their single-phase nature (sp. gr. P-3m1).
Poitou Marine, Normani Simone, Loiko Pavel, Braud Alain, Camy Patrice, Merdrignac-Conanec Odile   +5 more
doaj   +1 more source