Results 41 to 50 of about 1,265,097 (315)

Aligned representation of visual and tactile motion directions in hMT+/V5 and fronto-parietal regions

Nature Communications
Moving events on the skin can be perceived through vision and touch. How does the brain create a unified multisensory representation of motion directions initially acquired in different coordinate systems?
Iqra Shahzad, Ceren Battal, Filippo Cerpelloni, Alice Van Audenhaege, André Mouraux, Olivier Collignon   +5 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies

Nature Communications, 2023
Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies.
Nathalie Kyalu Ngoie Zola, Clémence Balty, Sébastien Pyr dit Ruys, Axelle A. T. Vanparys, Nicolas D. G. Huyghe, Gaëtan Herinckx, Manuel Johanns, Emilien Boyer, Pascal Kienlen-Campard, Mark H. Rider, Didier Vertommen, Bernard J. Hanseeuw   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Mass spectrometry of alkylbenzenes and related compounds. Part II. Gas phase ion chemistry of protonated alkylbenzenes (alkylbenzenium ions)

, 1990
Kuck D. Mass spectrometry of alkylbenzenes and related compounds. Part II. Gas phase ion chemistry of protonated alkylbenzenes (alkylbenzenium ions). Mass Spectrometry Reviews.
Kuck, Dietmar
core   +1 more source

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology

Acta Neuropathologica Communications, 2023
Aging is the main risk factor for Alzheimer’s disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying pathological aging of the nervous system are poorly understood. AD pathology seems to correlate with the
Nuria Suelves, Shirine Saleki, Tasha Ibrahim, Debora Palomares, Sebastiaan Moonen, Marta J. Koper, Céline Vrancx, Devkee M. Vadukul, Nicolas Papadopoulos, Nikenza Viceconte, Eloïse Claude, Rik Vandenberghe, Christine A. F. von Arnim, Stefan N. Constantinescu, Dietmar Rudolf Thal, Anabelle Decottignies, Pascal Kienlen-Campard   +16 more
doaj   +1 more source

Variability of the Chemical Composition of the Atmospheric Aerosol in the Coastal Zone of the Southern Basin of Lake Baikal (East Siberia, Russia)

Atmosphere, 2022
The role of the atmosphere in the formation of the chemical composition and quality of water in Lake Baikal and its tributaries has been increasing in recent years. In this regard, studies of the chemical composition of the constituents of the atmosphere
Liudmila P. Golobokova, Tamara V. Khodzher, Galina S. Zhamsueva, Alexander S. Zayakhanov, Alexey Starikov, Olga I. Khuriganova   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Telomere-driven senescence accelerates tau pathology, neuroinflammation and neurodegeneration in a tauopathy mouse model

Acta Neuropathologica Communications
The connection between aging and neurodegenerative pathologies like Alzheimer’s disease (AD) has long been recognized, with senescent brain cells building up in the brains of AD patients.
Debora Palomares, Axelle A. T. Vanparys, Joana Jorgji, Esther Paître, Pascal Kienlen-Campard, Nuria Suelves   +5 more
doaj   +1 more source