Results 41 to 50 of about 61,090 (217)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Neural representation of the musical beat is facilitated but not contingent on the repetition of rhythmic patterns

Scientific Reports
Music often entails perception of periodic beats which serve as internal temporal references to coordinate movements to music. Crucially, beat perception arises even in syncopated musical rhythms, which only weakly cue the beat periodicity.
Emmanuel Coulon, Sacha Baum, Tomas Lenc, Rainer Polak, Sylvie Nozaradan   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Mid-infrared emissions of Dy3+ ions in CaF2 [PDF]

EPJ Web of Conferences
We report on a comprehensive spectroscopic study of singly Dy3+ doped and Er3+,Dy3+ codoped calcium fluoride (CaF2) crystals for mid- infrared laser applications. The f-f transition probabilities of Dy3+ were determined by the Judd-Ofelt theory.
Nguyen Ngoc Quynh Hoa, Loiko Pavel, Benayad Abdelmjid, Kornienko Aleksei, Dunina Elena, Fomicheva Liudmila, Camy Patrice, Braud Alain   +7 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Neural substrates underlying motor skill learning in chronic hemiparetic stroke patients

Frontiers in Human Neuroscience, 2015
Motor skill learning is critical in post-stroke motor recovery, but little is known about its underlying neural substrates. Recently, using a new visuomotor skill learning paradigm involving a speed/accuracy trade-off in healthy individuals we identified
Stephanie eLefebvre, Stephanie eLefebvre, Laurence eDricot, Patrice eLaloux, Patrice eLaloux, wojciech eGradkowski, wojciech eGradkowski, Philippe eDesfontaines, Frédéric eEvrard, Andre ePeeters, Jacques eJamart, Yves eVandermeeren, Yves eVandermeeren, Yves eVandermeeren   +13 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol

Frontiers in Neuroscience
Despite the proven efficacy of vagus nerve stimulation (VNS) in seizure control, its precise mechanism of action remains unclear. VNS is known to impact the cardiorespiratory system.
Javier Chávez Cerda, Elena Acedo Reina, Ayse S. Dereli, Louis Vande Perre, Romain Raffoul, Maxime Verstraeten, Michel-Antony Ngan Yamb, Enrique Germany Morrison, Elise Collard, Auriane Apaire, Pascal Doguet, Jérôme Garnier, Jean Delbeke, Riëm El Tahry, Antoine Nonclercq   +14 more
doaj   +1 more source