Intraductal Oncocytic Papillary Neoplasm (IOPN): Two Case Reports and Review of the Literature [PDF]
Translational Cancer Research, 2023 Intraductal oncocytic papillary neoplasms (IOPNs) place at the oncocytic extreme of the intraductal pancreatic neoplasm spectrum and display typical morphological features. Their identification in 1996 by Adsay et al. has been followed by a growing number of cases, paving the way for a deeper understanding of this underestimated entity.
Daniela Campani +2 more
exaly +4 more sources
Characterization and Digital Spatial Deconvolution of the Immune Microenvironment of Intraductal Oncocytic Papillary Neoplasms (IOPN) of the Pancreas [PDF]
Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin, 2023 AbstractIntraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a distinct entity from intraductal papillary mucinous neoplasms (IPMNs) and is considered one of the precursor lesions of pancreatic cancer. Through immunohistochemistry (IHC) and an artificial intelligence (AI)-based approach, this study aims at characterizing its immune ...
Claudio Luchini, Paola Piccoli
exaly +4 more sources
Editorial for IOPN 2024 January June Issue
Indian Journal of Psychiatric NursingMuthuvenkatachalan Srinivasan
exaly +4 more sources
OPN promotes pro-inflammatory cytokine expression via ERK/JNK pathway and M1 macrophage polarization in Rosacea [PDF]
Frontiers in Immunology, 2023 Rosacea is a chronic inflammatory dermatosis that involves dysregulation of innate and adaptive immune systems. Osteopontin (OPN) is a phosphorylated glycoprotein produced by a broad range of immune cells such as macrophages, keratinocytes, and T cells ...
Siyi Tang +8 more
doaj +2 more sources
Oncocytic intraductal papillary neoplasm of the pancreas: Multimodality imaging and cytopathologic correlation [PDF]
South African Journal of RadiologyIntraductal oncocytic papillary neoplasm of the pancreas (IOPN-P) is a rare cystic epithelial tumour with distinctive imaging, cytological and histological features.
Anju Ranga +5 more
doaj +2 more sources
Two different isoforms of osteopontin modulate myelination and axonal integrity [PDF]
FASEB BioAdvances, 2023 Abnormal myelination underlies the pathology of white matter diseases such as preterm white matter injury and multiple sclerosis. Osteopontin (OPN) has been suggested to play a role in myelination.
Gisela Nilsson +12 more
doaj +2 more sources
Deciphering pancreatobiliary intraductal oncocytic papillary neoplasms: integrative analysis of histomorphologic patterns, immunophenotypic markers, and emerging molecular biomarkers [PDF]
World Journal of Surgical OncologyPurpose We reviewed recent advancements in the characterization of intraductal oncocytic papillary neoplasm (IOPN) of the pancreas, with a specific focus on developments in immunohistochemical markers, molecular pathology, and pathogenic mechanisms over ...
Yingxian Qian +2 more
doaj +2 more sources
Case Report: Metachronous oncocytic and colloid carcinoma arising from pancreatic intraductal neoplasms over four decades [PDF]
Frontiers in OncologyIntraductal papillary mucinous neoplasms (IPMN) are precursors of pancreatic ductal adenocarcinoma (PDAC) and may progress to distinct invasive phenotypes depending on epithelial subtypes. Tubular carcinoma, often arising from pancreatobiliary epithelium,
Maria Imperatrice +5 more
doaj +2 more sources
MRI findings of pancreatic intraductal oncocytic papillary neoplasm: three case reports and review of literature [PDF]
Frontiers in MedicineBackgroundPancreatic intraductal oncocytic papillary neoplasms (IOPNs) are uncommon precancerous lesions frequently mistaken for other tumors because of their similar imaging characteristics. The concept of IOPN was first proposed by Adsay et al. in 1996.
Yunan Xiang +10 more
doaj +2 more sources
Intraductal oncocytic papillary neoplasm arising in Peutz-Jeghers Syndrome bile duct: a unique case report [PDF]
Diagnostic Pathology, 2022 Background Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant disorder caused by germline mutations of STK11/LKB1, with an increased risk of tumors at multiple sites.
Qingyue Liu +7 more
doaj +2 more sources