Results 11 to 20 of about 409 (119)

Intracellular osteopontin potentiates the immunosuppressive activity of mesenchymal stromal cells [PDF]

Stem Cell Research & Therapy
Introduction Mesenchymal stromal cell (MSC)-based cell therapy is a promising approach for various inflammatory disorders based on their immunosuppressive capacity.
Wanlin Yang, Min Jin, Yuting Gu, Xiaonan Zhao, Lingqiao Zhu, Shan He, Hui Wang, Xinyuan Ding, Bei Wang, Tingwang Jiang, Yichuan Xiao, Guoqiang Zhou, Jiefang Huang, Yanyun Zhang   +13 more
doaj   +2 more sources

Non-invasive intraductal oncocytic papillary neoplasm forming a protruding lesion toward the duodenum from the accessory papilla: a case report [PDF]

Surgical Case Reports
Background Intraductal oncocytic papillary neoplasm (IOPN), previously classified as a subtype of intraductal papillary mucinous neoplasm (IPMN), has been described as an independent disease by the WHO since 2019.
Shinnosuke Kawahara, Naoto Yamamoto, Kota Washimi, Rei Kanemoto, Daishi Takahashi, Yuto Kamioka, Itaru Hashimoto, Mariko Kamiya, Aya Kato, Yukio Maezawa, Keisuke Kazama, Masaaki Murakawa, Sho Sawazaki, Toru Aoyama, Hiroshi Tamagawa, Takashi Oshima, Norio Yukawa, Yasushi Rino, Tomoyuki Yokose, Aya Saito, Soichiro Morinaga   +20 more
doaj   +2 more sources

Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling [PDF]

Molecular Cancer, 2022
Background Autoimmune disorders, including Systemic Lupus Erythematosus (SLE), are associated with increased incidence of hematological malignancies. The matricellular protein osteopontin (OPN) has been linked to SLE pathogenesis, as SLE patients show ...
Celeste Rizzello, Valeria Cancila, Sabina Sangaletti, Laura Botti, Chiara Ratti, Matteo Milani, Matteo Dugo, Francesco Bertoni, Claudio Tripodo, Claudia Chiodoni, Mario P. Colombo   +10 more
doaj   +2 more sources

A missed case of intraductal oncocytic papillary neoplasm associated with missed stones in extrahepatic bile duct: a case report [PDF]

Frontiers in Oncology
The pathological features of intraductal oncocytic papillary neoplasm (IOPN) of the bile duct include tumor cells that are rich in eosinophilic cytoplasm and arranged in papillary structures.
Cong Xie, Hang Zhang, Hang Zhang, Yushan Meng, Yushan Meng, Bin Cao   +5 more
doaj   +2 more sources

Metastasis of Pancreatic Intraductal Oncocytic Papillary Neoplasm to the Ovaries. [PDF]

Case Rep Gastrointest Med
Objectives Intraductal oncocytic papillary neoplasm (IOPN) is a digestive system tumor typically found in the head of the pancreas. Most often, they remain confined to the pancreas; it is rare that they develop into an invasive carcinoma or metastasize.
Fronk E, McDowell J, Yanchenko N, Katerji H, Smith A.   +4 more
europepmc   +2 more sources

Eosinophilic Biliary Cystic Neoplasm of the Liver: A Case Report of an Unrecognized Subtype of Intrahepatic Biliary Neoplasm. [PDF]

Pathol Int
A distinct multicystic intrahepatic neoplasm composed of low‐grade tumor cells with brush border‐like microvilli and abundant granular eosinophilic cytoplasm is described, for which we propose the term “eosinophilic biliary cystic neoplasm of the liver.” The tumor harbors KRAS p.G12V driver mutation.
Tanaka M, Koinuma D, Hinata M, Takeshita K, Yasunaga Y, Sakuma K, Takamoto T, Nishioka Y, Hasegawa K, Nakai Y, Ushiku T.   +10 more
europepmc   +2 more sources

Clinicopathological features of pancreatic intraductal oncocytic papillary neoplasm: a report of 5 cases [PDF]

Waike lilun yu shijian, 2022
Objective To analyze the clinicopathological features of pancreatic intraductal oncocytic papillary neoplasm (IOPN). Methods Five cases with pancreatic IOPN were in Ruijin Hospital including 3 female and 2 male, and the average age (60.0±10.4 ...
YANG Chunxue, XU Haimin, DA Qian
doaj   +1 more source

Intracellular osteopontin (iOPN) and immunity [PDF]

Immunologic Research, 2010
Osteopontin (OPN) is a protein involved in various pathophysiological events. OPN has been studied as a secreted protein, but recent reports showed that OPN can be found in the cytoplasm and the nucleus. Therefore, some OPN molecules are not secreted and stay in cells.
Makoto, Inoue, Mari L, Shinohara
openaire   +2 more sources

Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system. [PDF]

Histopathology
Changes and new entities in the 6th edition WCT of the digestive system, including structural, molecular, and diagnostic updates to standardize terminology and improve clinical relevance. Epithelial tumours are organized by site; neuroendocrine, mesenchymal and haematolymphoid tumours have dedicated chapters, with refined grading, redefined ...
Arends MJ, Esposito I, Gill AJ, Hruban RH, Khoury JD, Kojima M, Montgomery EA, Abdulkareem F, Carneiro F, Costamagna G, Lauwers G, Polydorides AD, Rindi G, Rugge M, Schirmacher P, Srivastava A, Yao J, Hodge JC, Kench JG, Rekhi B, Reyes-Múgica M, Sepulveda AR, Shi C, Puspanathan P, Wijesinghe H, Giesen C, Ruiz BII, Lokuhetty D, WCT standing editorial board, Nagtegaal ID.   +29 more
europepmc   +2 more sources

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells. [PDF]

PLoS ONE, 2017
Glucose-stimulated insulin secretion (GSIS) relies on β-cell Ca2+ influx, which is modulated by the two-pore-domain K+ (K2P) channel, TALK-1. A gain-of-function polymorphism in KCNK16, the gene encoding TALK-1, increases risk for developing type-2 ...
Matthew T Dickerson, Nicholas C Vierra, Sarah C Milian, Prasanna K Dadi, David A Jacobson   +4 more
doaj   +1 more source