Results 81 to 90 of about 2,476,585 (264)

Dwie wizje człowieka - dwie wizje Europy

Chrześcijaństwo-Świat-Polityka, 2017
Artykuł broni tezy, iż współczesne spory o kształt Europy związane są ze sporem dwóch antropologii. Pierwsza z nich, określana tutaj jako antropologia ograniczona, pojmuje człowieka jako stworzenie, a zatem byt w swojej naturze ograniczony i ...
Michał Gierycz, Ks. Piotr Mazurkiewicz
doaj   +1 more source

Islands of Effective International Adjudication: Constructing an Intellectual Property Rule of Law in the Andean Community [PDF]

, 2009
The Andean Community - a forty-year-old regional integration pact of small developing countries in South America - is widely viewed as a failure. In this Article, we show that the Andean Community has in fact achieved remarkable success within one part ...
Alter, Karen J., Guerzovich, M. Florencia, Helfer, Laurence R.   +2 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Velocity profiles of interplanetary shocks [PDF]

, 1983
The type 2 radio burst was identified as a shock propagating through solar corona. Radio emission from shocks travelling through the interplanetary (IP) medium was observed.
Cane, H. V.
core   +1 more source

Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing

, 2006
Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium oscillations (CaOs ...
A. P. R. Theuvenet, C. C. A. M. Gielen, D. L. Ypey, J. Guckenheimer, J. M. A. M. Kusters, J. M. Cortes, J. D. Murray, O. Aslanidi, T. R. Chay, W. P. M. van Meerwijk   +9 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

?????????????????? ???????????????? ?? ?????????????? ?????????????? ???? ???????????? ?????????????????????????? ?????????????????????????? ???????????????? ?????????????????? ?????????????? IP-?????????????? [PDF]

, 2019
?????????????????????????????? ???????????????????????? ?????????? ?????????????????????????????? ???????????????? ?????????????? ?? ?????????? ?????????????????????? ?? ???????????? ?????????????????? ???????????????? ?? ?????????????? IP-??????????????. ?? ?????????????????? ?????????????? ???????????????????? ?????????????? ???????????????? ?????????
openaire   +3 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Evaluating the Impact of an Interprofessional Practice Experience Involving Pharmacy and Dental Students on Medication Histories within an Urban Academic Dental Admissions Clinic [PDF]

, 2016
Primary Objective: To compare interprofessional (IP) care versus standard care on medication history clarifications in dental patients. Secondary Objectives: To assess the clinical significance of these clarifications with regards to the potential ...
Idahosa, BDS, DDS, MS, Chizobam, MacPhail, DMD, PhD, Laurie A., Myers Virtue PsyD, Shannon, Radovanovich, PharmD Candidate, Alexander, Rotz, PharmD, BCPS, Melissa E., Theordorou PharmD, BCPS, Jacqueline M., von Vital, PharmD Candidate, Rachel, Zhao, PhD, Huaqing   +7 more
core   +1 more source