Results 141 to 150 of about 1,266,606 (191)
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Dynamic clustering of IP3 receptors by IP3
Biochemical Society Transactions, 2012The versatility of Ca2+ as an intracellular messenger stems largely from the impressive, but complex, spatiotemporal organization of the Ca2+ signals. For example, the latter when initiated by IP3 (inositol 1,4,5-trisphosphate) in many cells manifest hierarchical recruitment of elementary Ca2+ release events (‘blips’ and then ‘puffs’) en route to ...
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Reduced IP3 sensitivity of IP3 receptor in Purkinje neurons
Neuroreport, 2001The inositol 1,4,5-trisphosphate receptor (IP3R) is highly expressed in Purkinje neurons (PNs) and is thought to be essential for the induction of long-term depression at parallel-fiber-PN synapses. Here, by imaging the fluorescence intensity of the low-affinity Ca2+ indicator inside the Ca2+ stores in the permeabilized single PNs, we analyzed the ...
A, Fujiwara +3 more
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Biochemical Society Transactions, 2006
IP3Rs (inositol 1,4,5-trisphosphate receptors) are expressed in the membranes of non-mitochondrial organelles in most animal cells, but their presence and role within the plasma membrane are unclear. Whole-cell patch–clamp recording from DT40 cells expressing native or mutated IP3Rs has established that each cell expresses just two or three functional ...
C W, Taylor, O, Dellis
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IP3Rs (inositol 1,4,5-trisphosphate receptors) are expressed in the membranes of non-mitochondrial organelles in most animal cells, but their presence and role within the plasma membrane are unclear. Whole-cell patch–clamp recording from DT40 cells expressing native or mutated IP3Rs has established that each cell expresses just two or three functional ...
C W, Taylor, O, Dellis
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Structure and function of IP3 receptors
Seminars in Cell Biology, 1994The molecular, structural and functional characteristics of the intracellular Ca2+ release channel activated by inositol 1,4,5-trisphosphate (IP3), also named IP3 receptor (IP3R), are described here. We also discuss the differences in primary structure, expression and modulation of the receptor subtypes and their physiological roles. The similarity and
K, Mikoshiba, T, Furuichi, A, Miyawaki
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Dual regulation of IP3 receptors by IP3 and PIP2 controls the transition from local to global Ca2+ signals [PDF]
Molecular CellThe spatial organization of inositol 1,4,5-trisphosphate (IP3)-evoked Ca2+ signals underlies their versatility. Low stimulus intensities evoke Ca2+ puffs, localized Ca2+ signals arising from a few IP3 receptors (IP3Rs) within a cluster tethered beneath ...
Colin Taylor, Maria Marti-Solano
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Analysis of IP3 receptors in and out of cells
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012Inositol 1,4,5-trisphosphate receptors (IP3R) are expressed in almost all animal cells. Three mammalian genes encode closely related IP3R subunits, which assemble into homo- or hetero-tetramers to form intracellular Ca2+ channels.In this brief review, we first consider a variety of complementary methods that allow the links between IP3 binding and ...
Ana M, Rossi +4 more
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Structural and dynamic insights into the subtype-specific IP3-binding mechanism of the IP3 receptor
Biochemical Journal, 2016There are three subtypes of vertebrate inositol 1,4,5-trisphosphate (IP3) receptor (IP3R), a Ca2+-release channel on the ER membrane — IP3R1, IP3R2, and IP3R3 — each of which has a distinctive role in disease development. To determine the subtype-specific IP3-binding mechanism, we compared the thermodynamics, thermal stability, and conformational ...
Su Youn, Lee +4 more
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IP3 receptors and their regulation by calmodulin and cytosolic Ca2+
Cell Calcium, 2002Inositol 1,4,5-trisphosphate (IP(3)) receptors are tetrameric intracellular Ca(2+) channels, the opening of which is regulated by both IP(3) and Ca(2+). We suggest that all IP(3) receptors are biphasically regulated by cytosolic Ca(2+), which binds to two distinct sites.
Taylor CW, Laude AJ
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Structural organization of signalling to and from IP3 receptors
Biochemical Society Transactions, 2014In the 30 years since IP3 (inositol 1,4,5-trisphosphate) was first shown to release Ca2+ from intracellular stores, the importance of spatially organized interactions within IP3-regulated signalling pathways has been universally recognized. Recent evidence that addresses three different levels of the structural determinants of IP3-evoked Ca2 ...
Colin W, Taylor +5 more
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Rapid functional assays of recombinant IP3 receptors
Cell Calcium, 2005Functional assays of inositol 1,4,5-trisphosphate receptors (IP3R) currently use 45Ca2+ release methods, fluorescent Ca2+ indicators within either the ER or cytosol, or electrophysiological analyses of IP3R in the nuclear envelope or artificial bilayers.
Laude AJ +5 more
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