Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in <i>Trypanosoma cruzi</i>. [PDF]
mBioBertolini MS +9 more
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Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders. [PDF]
BiomoleculesOnu CJ +4 more
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Towards Improved Bioavailability of Cereal Inositol Phosphates, <i>Myo</i>-Inositol and Phenolic Acids. [PDF]
MoleculesŻyła K, Duda A.
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The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid
Kleinpeter AB +9 more
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Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy
Biomolecules, 2023 IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. It is a poly-phosphorylated inositol derivative that has been shown to exhibit many biological activities that accrue benefits in health and diseases (cancer, diabetes, renal lithiasis, cardiovascular diseases, etc.). IP6 has been shown to have several cellular and molecular
Felix O Omoruyi
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IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating [PDF]
Viruses, 2018 The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood. Recent discoveries of positively-charged rings in the immature and mature protein hexamer subunits that comprise them and their binding to the cellular metabolite inositol hexakisphosphate (IP6) have ...
Robert A Dick +2 more
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Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics [PDF]
Molecular Cell, 2016 The ring-shaped cohesin complex regulates transcription, DNA repair, and chromosome segregation by dynamically entrapping chromosomes to promote chromosome compaction and sister-chromatid cohesion. The cohesin ring needs to open and close to allow its loading to and release from chromosomes. Cohesin dynamics are controlled by the releasing factors Pds5
Zhuqing Ouyang +2 more
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Monitoring Intracellular IP6 with a Genetically Encoded Fluorescence Biosensor
ACS Sensors, 2023Inositol hexakisphosphate (IP6), a naturally occurring metabolite of inositol with specific functions in different organelles or tissues, participates in numerous physiological processes and plays a key role in mammalian metabolic regulation. However, current IP6 detection methods, i.e., high-performance liquid chromatography and gel electrophoresis ...
Xi Li +6 more
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IP6: A novel anti-cancer agent
Life Sciences, 1997Inositol hexaphosphate (InsP6 or IP6) is ubiquitous. At 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) as well as inositol (Ins) are contained in most mammalian cells, wherein they are important in regulating vital cellular functions such as signal transduction, cell proliferation and differentiation. A striking anti-
A M, Shamsuddin, I, Vucenik, K E, Cole
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