Results 31 to 40 of about 54,679 (264)

Real-world comparative effectiveness of second-line ipilimumab for metastatic melanoma: a population-based cohort study in Ontario, Canada

BMC Cancer, 2020
Background For novel cancer treatments, effectiveness in clinical practice is not always aligned with clinical efficacy results. As such it is important to understand a treatment’s real-world effectiveness.
Wei Fang Dai, Jaclyn M. Beca, Ruth Croxford, Wanrudee Isaranawatchai, Ines B. Menjak, Teresa M. Petrella, Nicole Mittmann, Craig C. Earle, Scott Gavura, Timothy P. Hanna, Kelvin K.W. Chan   +10 more
doaj   +1 more source

Combined Nivolumab and Ipilimumab or Monotherapy in Previously Untreated Melanoma

New England Journal of Medicine, 2015
Background The results of phase 1 and phase 2 studies suggest that nivolumab (a PD-1 checkpoint inhibitor) and ipilimumab (a CTLA-4 checkpoint inhibitor) have complementary activity in metastatic melanoma. In this randomized, double-blind, phase 3 study,
J. Larkin, V. Chiarion-Sileni, R. Gonzalez, J. Grob, C. Cowey, C. Lao, D. Schadendorf, R. Dummer, M. Smylie, P. Rutkowski, P. Ferrucci, A. Hill, J. Wagstaff, M. Carlino, J. Haanen, M. Maio, I. Márquez-Rodas, G. McArthur, P. Ascierto, G. Long, M. Callahan, M. Postow, M. Postow, K. Grossmann, M. Sznol, B. Dréno, L. Bastholt, A. Yang, L. Rollin, C. Horak, F. Hodi, J. Wolchok, J. Wolchok   +32 more
semanticscholar   +1 more source

Treatment of Ipilimumab Induced Graves’ Disease in a Patient with Metastatic Melanoma

Case Reports in Endocrinology, 2016
Objective. Thyroid disease has been reported among the endocrinopathies that can occur after treatment with ipilimumab. Graves’ disease, however, has been rarely reported with this medication.
Umal Azmat, David Liebner, Amy Joehlin-Price, Amit Agrawal, Fadi Nabhan   +4 more
doaj   +1 more source

Cost-Effectiveness of Nivolumab Plus Ipilimumab as First-Line Therapy in Advanced Non–small-cell Lung Cancer

Frontiers in Pharmacology, 2021
Purpose: The effectiveness of nivolumab plus ipilimumab for advanced non-small cell lung cancer (NSCLC) has been demonstrated. Decisions have to be made about allocating healthcare resources.
Xuezhi Hao, Aizong Shen, Bin Wu
doaj   +1 more source

Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma.

New England Journal of Medicine, 2022
BACKGROUND Immune checkpoint inhibitors and targeted therapies have dramatically improved outcomes in patients with advanced melanoma, but approximately half these patients will not have a durable benefit.
M. Rohaan, T. H. Borch, J. H. van den Berg, Ö. Met, R. Kessels, M. G. Geukes Foppen, J. Stoltenborg Granhøj, B. Nuijen, C. Nijenhuis, I. Jedema, M. van Zon, Saskia Scheij, J. Beijnen, Marten Hansen, C. Voermans, I. M. Noringriis, T. Monberg, R. Holmstroem, L. Wever, M. van Dijk, L. Grijpink-Ongering, Ludy H.M. Valkenet, A. Torres Acosta, M. Karger, J. Borgers, Renske M T ten Ham, V. Retèl, W. V. van Harten, F. Lalezari, H. van Tinteren, A. V. D. van der Veldt, G. Hospers, Marion A. Stevense-den Boer, K. Suijkerbuijk, M. Aarts, D. Piersma, A. van den Eertwegh, J. D. de Groot, G. Vreugdenhil, E. Kapiteijn, M. Boers-Sonderen, W. Fiets, F. van den Berkmortel, E. Ellebaek, L. Hölmich, A. V. Van Akkooi, W. V. van Houdt, M. Wouters, J. V. van Thienen, C. Blank, A. Meerveld-Eggink, S. Klobuch, S. Wilgenhof, T. Schumacher, M. Donia, I. Svane, J. Haanen   +56 more
semanticscholar   +1 more source

Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma

Journal of Clinical Oncology, 2021
PURPOSE In the phase III CheckMate 067 trial, durable clinical benefit was demonstrated previously with nivolumab plus ipilimumab and nivolumab alone versus ipilimumab. Here, we report 6.5-year efficacy and safety outcomes.
J. Wolchok, V. Chiarion-Sileni, R. Gonzalez, J. Grob, P. Rutkowski, C. Lao, C. Cowey, D. Schadendorf, J. Wagstaff, R. Dummer, P. Ferrucci, M. Smylie, M. Butler, A. Hill, I. Márquez-Rodas, J. Haanen, M. Guidoboni, M. Maio, P. Schöffski, M. Carlino, C. Lebbé, G. McArthur, P. Ascierto, G. Daniels, G. Long, T. Bas, C. Ritchings, J. Larkin, F. Hodi   +28 more
semanticscholar   +1 more source

The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network. [PDF]

PLoS ONE, 2013
Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients.
Caroline J Voskens, Simone M Goldinger, Carmen Loquai, Caroline Robert, Katharina C Kaehler, Carola Berking, Tanja Bergmann, Clemens L Bockmeyer, Thomas Eigentler, Michael Fluck, Claus Garbe, Ralf Gutzmer, Stephan Grabbe, Axel Hauschild, Rüdiger Hein, Gheorghe Hundorfean, Armin Justich, Ullrich Keller, Christina Klein, Christine Mateus, Peter Mohr, Sylvie Paetzold, Imke Satzger, Dirk Schadendorf, Marc Schlaeppi, Gerold Schuler, Beatrice Schuler-Thurner, Uwe Trefzer, Jens Ulrich, Julia Vaubel, Roger von Moos, Patrik Weder, Tabea Wilhelm, Daniela Göppner, Reinhard Dummer, Lucie M Heinzerling   +35 more
doaj   +1 more source

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer.

New England Journal of Medicine, 2019
BACKGROUND In an early-phase study involving patients with advanced non-small-cell lung cancer (NSCLC), the response rate was better with nivolumab plus ipilimumab than with nivolumab monotherapy, particularly among patients with tumors that expressed ...
M. Hellmann, L. Paz-Ares, R. Bernabé Caro, B. Żurawski, Sang-We Kim, E. Carcereny Costa, Keunchil Park, A. Alexandru, L. Lupinacci, Emmanuel de la Mora Jimenez, H. Sakai, I. Albert, A. Vergnenègre, S. Peters, K. Syrigos, F. Barlesi, M. Reck, H. Borghaei, J. Brahmer, K. O'Byrne, W. Geese, P. Bhagavatheeswaran, S. Rabindran, R. Kasinathan, F. Nathan, S. Ramalingam   +25 more
semanticscholar   +1 more source

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer

Nature, 2022
Standard first-line chemotherapy results in disease progression and death within one year in most patients with human epidermal growth factor receptor 2 (HER2)-negative gastro-oesophageal adenocarcinoma1–4.
K. Shitara, J. Ajani, M. Moehler, M. Garrido, C. Gallardo, L. Shen, K. Yamaguchi, L. Wyrwicz, T. Skoczylas, A. Bragagnoli, Tianshu Liu, M. Tehfé, E. Elimova, R. Brugés, T. Zander, Sérgio Jobim de Azevedo, R. Kowalyszyn, R. Pazo-Cid, M. Schenker, J. Cleary, P. Yanez, K. Feeney, M. Karamouzis, V. Poulart, M. Lei, H. Xiao, K. Kondo, Mingshun Li, Y. Janjigian   +28 more
semanticscholar   +1 more source

Real world treatment sequences and outcomes for metastatic renal cell carcinoma.

PLoS ONE, 2023
ObjectivesThe treatment landscape for metastatic renal cell carcinoma changed a lot in the last few years. This study aimed to assess the treatment sequences and outcomes for metastatic renal cell carcinoma in a real-world setting.Materials and methodsWe
Gu-Shun Lai, Jian-Ri Li, Shian-Shiang Wang, Chuan-Shu Chen, Chun-Kuang Yang, Chia-Yen Lin, Sheng-Chun Hung, Kun-Yuan Chiu, Shun-Fa Yang   +8 more
doaj   +1 more source