Results 41 to 50 of about 192,546 (245)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The spruce bark beetle Ips typographus in a changing climate [PDF]
, 2012 Outbreaks of the Spruce bark beetle Ips typographus are often triggered by storm and drought and have destroyed millions of cubic meters of wood. It is therefore a pest insect of economic importance in Europe.
Öhrn, Petter
core +1 more source
KESULITAN-KESULITAN DALAM IMPLEMENTASI KURIKULUM MATA PELAJARAN IPS SMP
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2016 The implementation of curriculum is an effort to implement a curriculum that has been designed. The main purpose of this article is to reveal the factors of the difficulties in implementation of curriculum of social studies in junior high school.
Eni Cahya Wijayati +2 more
doaj +1 more source
Frontiers in Drug Safety and Regulation, 2023 Introduction: The antimalarials chloroquine and hydroxychloroquine have been used for several decades in treating malaria and some autoimmune diseases—mainly rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)—with excellent efficacy and ...
Pedro Santos-Moreno +8 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Slow death of excellence: Eulogy of central institute of psychiatry, Ranchi
Indian Journal of PsychiatryThe Central Institute of Psychiatry (CIP), Ranchi, has been a cornerstone of Indian psychiatry since its founding in 1918, pioneering therapies, psychopharmacology, child and community mental health services, and training generations of psychiatrists. It
Gulesh Kumar, Amrit Pattojoshi
doaj +1 more source
Pendekatan Heutagogi: Sebuah alternatif dalam pembelajaran IPS pada masa pandemi Covid-19
Jurnal Teori dan Praksis Pembelajaran IPS, 2021 Abstrak Pembelajaran IPS memiliki orientasi menjadikan peserta didik sebagai aktor sosial yang memiliki kecerdasan sosial. Penulisan artikel ini memiliki tujuan untuk memberikan gagasan pada pembelajaran IPS di masa pandemi dengan pendekatan heutagogi ...
Danan Tricahyono
doaj
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Building Students' Learning Experience in Online Learning During Pandemic
Al-Ishlah: Jurnal Pendidikan, 2021 The practice of online learning during a pandemic is ideally able to provide independent learning for students. However, what happens is the loss of a meaningful learning experience.
Syaharuddin Syaharuddin +4 more
doaj +1 more source