Results 61 to 70 of about 192,546 (245)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

iPS-heps vs HepPre48hr_3mix_NormalizedData

, 2019
Microarray data for iPS cells and iPS cell-derived differentiated cells, iPS cell-derived hepatocytic cells, and primary hepatocytes harvested after 48hr culture (a mixture from 3 samples)
Nakagawa, Toshito, Ishida, Seiichi, Eriko Higashi (6787508), nobuaki shiraki (6787511), Takagi, Nobuyuki, Shoen Kume (184671), Shun Nakai (6787490), Shitamichi, Takahiro, Tomoya Miyoshi (6787505), Toshito Nakagawa (2364352), shiraki, nobuaki, Shibata, Ima, Wakabayashi, Satoshi, Jumpei Kiyokawa (6787499), Satoshi Wakabayashi (6787502), Kume, Shoen, Nobuyuki Takagi (5210180), Kiyokawa, Jumpei, Higashi, Eriko, Miyoshi, Tomoya, Takahiro Shitamichi (6787496), Seiichi Ishida (3449654), Yamaguchi, Hiroyuki, Inoue, Tomoaki, Hiroyuki Yamaguchi (187348), Tomoaki Inoue (2505328), Ima Shibata (6787493), Nakai, Shun   +27 more
core   +1 more source

IMPLEMENTASI PEMBELAJARAN IPS BERBASIS KURIKULUM 2013 MELALUI LESSON STUDY DI SEKOLAH MUHAMMADIYAH KARTASURA

Warta LPM, 2015
The purpose of this community service, assess and understand; 1) learning implementation strategy IPS (Social Sciences) Curriculum 2013 based on lesson study in  the  School of  Muhammadiyah  Kartasura.
Tjipto Subadi, Kuswaji Dwi Priyono, Dahroni Dahroni, M. Musyiyam   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Pengembangan Multimedia Interaktif dengan Topik Kolonialisme dan Imperialisme Di Indonesia pada Mata Pelajaran IPS Kelas VIII

Jurnal Inovasi dan Teknologi Pembelajaran, 2019
Abstrak: Tujuan dari penelitian ini untuk menghasilkan multimedia interaktif yang dapat digunakan untuk pembelajaran mandiri yang telah melalui serangkaian validasi sehingga dapat digunakan dalam mata pelajaran IPS kelas VIII. Jenis penelitian ini adalah
Ardian Ramadhan Wijaya, Dedi Kuswandi, Susilaningsih Susilaningsih   +2 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Profiling the microRNA Expression in Human iPS and iPS-derived Retinal Pigment Epithelium

, 2014
The purpose of this study is to characterize the microRNA (miRNA) expression profiles of induced pluripotent stem (iPS) cells and retinal pigment epithelium (RPE) derived from induced pluripotent stem cells (iPS-RPE).
Jane Shen-Gunther, Heuy-Ching Wang, Hong Cai, Whitney A. Greene, Ramesh R. Kaini, Hung-I H Chen, Yufeng Wang, Hong Car   +7 more
core   +1 more source