Results 61 to 70 of about 74,131 (258)

Pengembangan Multimedia Interaktif dengan Topik Kolonialisme dan Imperialisme Di Indonesia pada Mata Pelajaran IPS Kelas VIII

Jurnal Inovasi dan Teknologi Pembelajaran, 2019
Abstrak: Tujuan dari penelitian ini untuk menghasilkan multimedia interaktif yang dapat digunakan untuk pembelajaran mandiri yang telah melalui serangkaian validasi sehingga dapat digunakan dalam mata pelajaran IPS kelas VIII. Jenis penelitian ini adalah
Ardian Ramadhan Wijaya, Dedi Kuswandi, Susilaningsih Susilaningsih   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

IP STOCK 2.0 _ IP COINS, IP SHARES & IP INDEXES

This technical specification defines IP Stock 2.0, a breakthrough, self-regulating market infrastructure that materializes hidden Intellectual Property (IP) value ($65–100 trillion) without altering corporate balance sheets or legacy accounting frameworks (IAS 38, IFRS, GAAP).
Michelle, Victor, Michelle, Natalie, Michelle, Emilie, Michelle, Elias   +3 more
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Simulation strength tests of a CLAAS ARION 610 rail-road tractor’s load-bearing structure (pt. 2)

Pojazdy Szynowe, 2020
In the first part of the article published in Rail Vehicles No. 2/2020, selected results of simulation tests of the strength of the front part of the supporting structure of the CLAAS ARION 610 tractor were presented.
Marian Medwid, Karol Bryk, Dawid Witkowski, Emil Kaźmierczak   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Leveraging Graph Neural Networks for IoT Attack Detection

Sakarya University Journal of Computer and Information Sciences
The widespread adoption of Internet of Things (IoT) devices in multiple sectors has driven technological progress; however, it has simultaneously rendered networks vulnerable to advanced cyber threats.
Mevlüt Uysal, Erdal Özdoğan, Onur Ceran   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Predicción del riesgo cardiovascular e hipertensión arterial según Framingham en pacientes de atención primaria en salud. Estudio FRICC

Revista Colombiana de Medicina Física y Rehabilitación, 2016
Introducción La enfermedad cardiovascular (ECV) constituye la primera causa de muerte en todo el mundo. Objetivos: Identificar el riesgo cardiovascular y riesgo para hipertensión arterial en pacientes de atención primeria en salud.
Javier Eliecer Pereira Rodriguez, Lorena Boada-Morales, Devi Peñaranda Florez, María del Pilar Castellanos-Duarte   +3 more
doaj   +1 more source