Results 71 to 80 of about 192,546 (245)

Simulation strength tests of a CLAAS ARION 610 rail-road tractor’s load-bearing structure (pt. 2)

Pojazdy Szynowe, 2020
In the first part of the article published in Rail Vehicles No. 2/2020, selected results of simulation tests of the strength of the front part of the supporting structure of the CLAAS ARION 610 tractor were presented.
Marian Medwid, Karol Bryk, Dawid Witkowski, Emil Kaźmierczak   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Leveraging Graph Neural Networks for IoT Attack Detection

Sakarya University Journal of Computer and Information Sciences
The widespread adoption of Internet of Things (IoT) devices in multiple sectors has driven technological progress; however, it has simultaneously rendered networks vulnerable to advanced cyber threats.
Mevlüt Uysal, Erdal Özdoğan, Onur Ceran   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Olfaction in the Spruce Bark Beetle, Ips typographus [PDF]

, 2011
The bark beetle Ips typographus regularly kills spruce trees in the Palearctic. Spruces are colonized by means of attraction to an aggregation pheromone. Attraction is modulated by anti-attractive volatiles (NHV) from non-host plants.
Andersson, Martin
core   +1 more source

„Person-/Klientenzentrierte Supervision und Organisationsentwicklung“: Statut und Ausbildungsordnung von ÖGwG und IPS der APG

, 1997
PERSON dokumentiert im folgenden das Statut mitsamt der Ausbildungsordnung der neuen gemeinsamen Aus-, Fort-und Weiterbildung „Person-/Klientenzentrierte Supervision und Organisationsentwicklung“ des Instituts für Personzentrierte Studien der APG (IPS ...
ÖGwG, IPS der APG
core   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Predicción del riesgo cardiovascular e hipertensión arterial según Framingham en pacientes de atención primaria en salud. Estudio FRICC

Revista Colombiana de Medicina Física y Rehabilitación, 2016
Introducción La enfermedad cardiovascular (ECV) constituye la primera causa de muerte en todo el mundo. Objetivos: Identificar el riesgo cardiovascular y riesgo para hipertensión arterial en pacientes de atención primeria en salud.
Javier Eliecer Pereira Rodriguez, Lorena Boada-Morales, Devi Peñaranda Florez, María del Pilar Castellanos-Duarte   +3 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source