Results 81 to 90 of about 187,622 (243)

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Leveraging Graph Neural Networks for IoT Attack Detection

Sakarya University Journal of Computer and Information Sciences
The widespread adoption of Internet of Things (IoT) devices in multiple sectors has driven technological progress; however, it has simultaneously rendered networks vulnerable to advanced cyber threats.
Mevlüt Uysal, Erdal Özdoğan, Onur Ceran   +2 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Predicción del riesgo cardiovascular e hipertensión arterial según Framingham en pacientes de atención primaria en salud. Estudio FRICC

Revista Colombiana de Medicina Física y Rehabilitación, 2016
Introducción La enfermedad cardiovascular (ECV) constituye la primera causa de muerte en todo el mundo. Objetivos: Identificar el riesgo cardiovascular y riesgo para hipertensión arterial en pacientes de atención primeria en salud.
Javier Eliecer Pereira Rodriguez, Lorena Boada-Morales, Devi Peñaranda Florez, María del Pilar Castellanos-Duarte   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

iPS-heps vs HepPre48hr_3mix_NormalizedData

, 2019
Microarray data for iPS cells and iPS cell-derived differentiated cells, iPS cell-derived hepatocytic cells, and primary hepatocytes harvested after 48hr culture (a mixture from 3 samples)
Nakagawa, Toshito, Ishida, Seiichi, Eriko Higashi (6787508), nobuaki shiraki (6787511), Takagi, Nobuyuki, Shoen Kume (184671), Shun Nakai (6787490), Shitamichi, Takahiro, Tomoya Miyoshi (6787505), Toshito Nakagawa (2364352), shiraki, nobuaki, Shibata, Ima, Wakabayashi, Satoshi, Jumpei Kiyokawa (6787499), Satoshi Wakabayashi (6787502), Kume, Shoen, Nobuyuki Takagi (5210180), Kiyokawa, Jumpei, Higashi, Eriko, Miyoshi, Tomoya, Takahiro Shitamichi (6787496), Seiichi Ishida (3449654), Yamaguchi, Hiroyuki, Inoue, Tomoaki, Hiroyuki Yamaguchi (187348), Tomoaki Inoue (2505328), Ima Shibata (6787493), Nakai, Shun   +27 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Laporan akuntabilitas kinerja PPPPTK PKN dan IPS tahun 2018 [PDF]

, 2018
Laporan ini menyajikan informasi kinerja atas pencapaian sasaran strategis beserta indikator kinerjanya sebagaimana tertuang dalam Perjanjian Kinerja Tahun 2018.
PPPPTK PKn dan IPS, Tim
core