Results 101 to 110 of about 88,697 (303)
An introduction to the mathematical modeling of iPSCs
, 2021 The aim of this chapter is to convey the importance and usefulness of mathematical modelling as a tool to achieve a deeper understanding of stem cell biology. We introduce key mathematical concepts (random walk theory, differential equations and agent-based modelling) which form the basis of current descriptions of induced pluripotent stem cells.
Wadkin, Laura E +5 more
openaire +2 more sources
Advanced Materials Technologies, EarlyView.We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang +7 more
wiley +1 more source
Assessing the cell-mediated immune response towards iPSC-derivatives
, 2020 Clinical trials have, and continue to, evaluate induced-pluripotent stem cell (iPSC)-derived cells as a cellular therapy in the field of regenerative medicine.
Mehler, Vera Josefa
core +1 more source
Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering
Advanced Materials Technologies, EarlyView.Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman +4 more
wiley +1 more source
Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation
Advanced Materials Technologies, EarlyView.Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching +9 more
wiley +1 more source
Scientific ReportsOsteoporosis is a metabolic bone disease that impairs bone mineral density, microarchitecture, and strength. It requires continuous management, and further research into new treatment options is necessary.
Ye Ji Eom +5 more
doaj +1 more source
Reducing genomic instability in iPSCs
Oncotarget, 2015 Over the past 15 years, pluripotent cells, either embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), became a formidable cellular platform to study developmental biology, model disease in vitro and pursue new drug discoveries. Furthermore, the promise of using endless cell derivatives from pluripotent cells to treat incurable ...
Ruiz S, Fernandez-Capetillo O
openaire +2 more sources
Electrophysiology of iPSC-derived neurons (14 d).
, 2015 (A) Action potential firing and voltage-gated sodium channels in control neurons. Control iPSC-derived neurons could fire a single action potential with membrane potential -57mV (a) or multiple action potentials (d) in response to current injection, or ...
Gregory A. Grabowski (353044) +11 more
core +1 more source
Advanced Science, EarlyView.This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang +8 more
wiley +1 more source