Results 111 to 120 of about 88,697 (303)

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Development of immunocompatible pluripotent stem cells via CRISPR-based human leukocyte antigen engineering

Experimental and Molecular Medicine, 2019
Regenerative medicine: Engineering compatible stem cells Blocking the expression of genes that regulate the immune response in therapeutic stem cells could increase the chances of success following transplantation.
Yeonsue Jang, Jinhyeok Choi, Narae Park, Jaewoo Kang, Myungshin Kim, Yonggoo Kim, Ji Hyeon Ju   +6 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Directed differentiation of iPSC into intestinal organoids.

, 2018
(A) Schematic of the protocol employed to induce intestinal differentiation from iPSC. Cells are first induced to form endoderm followed by hindgut specification and formation of intestinal organoids in matrigel. (B) Bright field images showing formation
Cesar A. Sommer (110591), Francisco J. Molina-Estevez (5537372), Ignacio Caballero (290123), Gustavo Mostoslavsky (110612), Nicholas Skvir (5537369), Amalia Capilla (333620), Sanjib Chowdhury (222280), Andreia Gianotti-Sommer (110597)   +7 more
core   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack

, 2018
Key Points HLA-lacking iPSC-derived HSCs from aplastic anemia patients show a hematopoietic ability similar to wild-type iPSC-HSCs. iPSC-HSCs that lack HLA-B4002 escape specific T-cell attack.
Hiroyuki Takamatsu, Yoshiki Akatsuka, Mahmoud I. Elbadry, Yoshinori Yoshida, Tatsuhiko Ozawa, Takamasa Katagiri, Hiroshi Hamana, Tatsuya Imi, Hassan A. Hassanein, Koichi Akashi, Hiroyuki Kishi, J. Luis Espinoza, Shinji Nakao, Kazuhisa Chonabayashi, Kenichi Harada, Yoshitaka Zaimoku, Noriharu Nakagawa, Hiroyuki Maruyama, Amal Khalifa A. Noreldin, Katsuto Takenaka   +19 more
core   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Amyloid-β peptide triggers Fas-independent apoptosis and differentiation of neural progenitor cells

Neurobiology of Disease, 2005
Amyloid-β peptide (Aβ), derived from the amyloid-β precursor protein (APP), plays a central role in the pathogenesis of Alzheimer's disease and induces neuronal apoptosis.
Pascal Millet, Céline Silva Lages, Stéphane Haïk, Ewa Nowak, Isabelle Allemand, Christine Granotier, François D. Boussin   +6 more
doaj   +1 more source