Results 81 to 90 of about 116,955 (355)

Roadblocks in the Path of iPSC to the Clinic [PDF]

Current Transplantation Reports, 2018
The goal of this paper is to highlight the major challenges in the translation of human pluripotent stem cells into a clinical setting.Innate features from human induced pluripotent stem cells (hiPSCs) positioned these patient-specific cells as an unprecedented cell source for regenerative medicine applications.
Garreta, Elena, Sanchez, Sonia, Lajara, Jeronimo, Montserrat, Nuria, Belmonte, Juan Carlos Izpisua   +4 more
openaire   +3 more sources

Thermally Engineered Sodium‐Embedded Alumina with Programmable Synaptic Plasticity for Neuromorphic Transistors

Advanced Functional Materials, EarlyView.
A fully transparent, all‐metal‐oxide neuromorphic transistor using a sodium‐embedded alumina (SEA) electrolyte is demonstrated. By precisely tuning the thermal annealing process, the chemical composition of the SEA layer is controlled, allowing for the deterministic realization of both short‐term and long‐term synaptic plasticity within the same device
Yonghyun Albert Kwon, Jaeyeon Kim, Dong Yeon Won, Saeyoun Park, Youngjae Yoo, Seongchan Kim, Dong‐Hwan Kim, Jeong Ho Cho   +7 more
wiley   +1 more source

Generation of two tdTomato reporter induced pluripotent stem cell lines (NHLBIi003-A-1 and NHLBIi003-A-2) by AAVS1 safe harbor gene-editing

Stem Cell Research, 2020
Human induced pluripotent stem cells (iPSCs) that express stable and robust fluorescent proteins have proven to be indispensable in basic and translational research.
Kira Patterson, Kaari L. Linask, Jeanette Beers, Jizhong Zou   +3 more
doaj   +1 more source

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

iPSC Generation

, 2023
Creative Bioarray is dedicated to providing several viable and cost-effective methods for pluripotent stem cells (iPSC) generation. We employ advanced iPSC reprogramming factor delivery by episomal vectors, viral vectors, as well as other iPSC reprogramming methods (mRNA, protein and chemical reprogramming) to help you obtaining the desired iPSC.
openaire   +3 more sources

Assembly of Cell‐Seeded 3D Printed Hydrogel Modules with Perfusable Channel Networks

Advanced Functional Materials, EarlyView.
Macroscale assembly was utilized to prepare perfusable tissue constructs from individually 3D printed hydrogel modules with embedded branched channel networks and port arrays for cell seeding. Novel multi‐material bioreactors were fabricated to facilitate the gluing of individual modules and the perfusion culture of assembled modular constructs seeded ...
Zachary J. Geffert, Daniel Fougnier, Bo Van Durme, Jenna Grutzmacher, Ryan Clarke, Susan Cao, Zhenghao Li, Ujjwal Aryal, Jason A. Horton, Sandra Van Vlierberghe, Pranav Soman   +10 more
wiley   +1 more source

Metabolomic profiles of induced pluripotent stem cells derived from patients with rheumatoid arthritis and osteoarthritis

Stem Cell Research & Therapy, 2019
Background Metabolomics is the systemic study of the unique fingerprints of metabolites involved in cellular processes and biochemical reactions. The metabolomic approach is useful in diagnosing and predicting the development of rheumatoid arthritis (RA)
Juryun Kim, Sunyoung Christina Kang, Na Eun Yoon, Yena Kim, Jinhyeok Choi, Narae Park, Hyerin Jung, Byung Hwa Jung, Ji Hyeon Ju   +8 more
doaj   +1 more source

The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia [PDF]

, 2019
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ...
A.M. Lavoie, AR Woodruff, C Börgers, C-G Hahn, CA Brenner, Chi-Ming A. Chen, CL Beasley, D Vierling-Claassen, D Vierling-Claassen, David A. Lewis, David W. Volk, E Salinas, G Gonzalez-Burgos, GA Light, GP Krishnan, Hanna Thuné, Henry Markram, I Wonodi, J. Szabadics, Joshua T. Kantrowitz, JS Kwon, KM Spencer, KM Spencer, KM Spencer, L KRISTIANSEN, LS Overstreet, M Bartos, M Carlén, Monica Beneyto, Monika P. Jadi, MW Howard, N Hajos, Nadezhda V. Povysheva, P Fries, P Steullet, P Teale, Pascal Fries, R Tsuchimoto, Robin Tremblay, RY Cho, S Keros, T Hashimoto, T Mäki-Marttunen, T-U Woo, Tuomo Mäki-Marttunen, Y Kawaguchi   +45 more
core   +2 more sources

Identifying the dynamics of actin and tubulin polymerization in iPSCs and in iPSC-derived neurons

Oncotarget, 2017
The development of the nervous system requires cytoskeleton-mediated processes coordinating self-renewal, migration, and differentiation of neurons. It is not surprising that many neurodevelopmental problems and neurodegenerative disorders are caused by deficiencies in cytoskeleton-related genes.
Magliocca, Valentina, Petrini, Stefania, Franchin, Tiziana, Borghi, Rossella, Niceforo, Alessia, Abbaszadeh, Zeinab, Bertini, Enrico, Compagnucci, Claudia   +7 more
openaire   +3 more sources

Self‐Healing and Stretchable Synaptic Transistor

Advanced Functional Materials, EarlyView.
A self‐healing stretchable synaptic transistor (3S‐T) is realized using a p‐PVDF‐HFP‐DBP/PDMS‐MPU‐IU bilayer as gate insulator, where dipole‐dipole interaction enhances polarization to achieve a large memory window. Leveraging its neuronal biomimicry, the synaptic transistor demonstrates electrically compatibility with the biological brain. Furthermore,
Hyongsuk Choo, Sangyong Park, Yoonyi Jeong, Jaepyo Jang, Duhwan Seong, In Soo Kim, Myung‐Gil Kim, Mikyung Shin, Minah Suh, Donghee Son, Jin‐Hong Park   +10 more
wiley   +1 more source