Results 111 to 120 of about 104,261 (287)

Timeline: iPSCs—The First Decade

Cell, 2016
Research into induced pluripotent stem cells (iPSCs) has expanded at a remarkable pace in the decade since Shinya Yamanaka and Kazutoshi Takahashi first reported their groundbreaking discovery in 2006. This Timeline highlights the key events in the development of this field, including basic insights into the production of iPSCs and how they have been ...
Chari, Sheila, Mao, Steve
openaire   +2 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. [PDF]

, 2016
In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge's disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment ...
Appenzeller, Otto, Azad, Priti, Bafna, Vineet, Cabrales, Pedro J, Haddad, Gabriel G, Hsiao, Yu Hsin, Poulsen, Orit, Ronen, Roy, Zhao, Huiwen W, Zhou, Dan   +9 more
core  

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. [PDF]

, 2018
Ras/MAPK pathway signaling is a major participant in neurodevelopment, and evidence suggests that BRAF, a key Ras signal mediator, influences human behavior.
Camacho, FM, Dao, DQ, Kandalam, SM, Krencik, R, Rauen, KA, Tom, C, Ullian, EM, Weiss, LA, Wu, ZY, Yeh, E, Zhang, W   +10 more
core  

Photo‐Rewritable Ambipolar Organic Electrochemical Synapses with Bidirectional Optical Plasticity for Adaptive Vision in Aqueous Environments

Advanced Materials, EarlyView.
Photo‐rewritable ambipolar organic synapses operating in aqueous environments at low voltage (≤0.4 V) demonstrate bidirectional optical plasticity through photon‐modulated electrochemical doping. The bulk heterojunction device enables both excitatory and inhibitory responses with extended retention time (>130 min).
Xiaoqian Su, Xihu Wu, He Wang, Wenzhe Lu, Bing Xue, Jinli Tang, Zhangshanhao Li, Kejing Ren, Qiang He, Junyu Li, Lan Yin, Yuxin Liu, Shiming Zhang, Ting Lei, Changsheng Wu   +14 more
wiley   +1 more source

Self‐Powered Flexible Triboelectric‐Gated Ion‐Gel Transistor for Neuromorphic Tactile Sensing and Human Activity Recognition

Advanced Materials, EarlyView.
A fully flexible ion‐gel‐gated graphene‐channel transistor driven by a triboelectric nanogenerator enables self‐powered tactile sensing and synaptic learning. Mimicking spike‐rate‐dependent plasticity, the device exhibits frequency‐selective potentiation and depression, supporting rate‐coded neuromorphic computation even under flex.
Hanseong Cho, Seoyeon Park, Youngmin Lee, Sejoon Lee   +3 more
wiley   +1 more source

Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells

Stem Cells International, 2018
Scientists have tried to reprogram various origins of primary cells into human induced pluripotent stem cells (hiPSCs). Every somatic cell can theoretically become a hiPSC and give rise to targeted cells of the human body.
Yeri Alice Rim, Yoojun Nam, Narae Park, Hyerin Jung, Yeonsue Jang, Jennifer Lee, Ji Hyeon Ju   +6 more
doaj   +1 more source

Mitochondria fingerprint longevity in iPSCs

Oncotarget, 2015
The recent and powerful technology of the human induced pluripotent stem cells (iPSCs), (stem cells that are reprogrammed from easily obtainable adult somatic cells such as skin fibroblasts), allows for example to study the pathogenesis of still poorly known human diseases, to perform drug screenings or even to be used in translational medicine [1 ...
Andrea, Masotti, Enrico, Bertini, Claudia, Compagnucci   +2 more
openaire   +2 more sources

Poking Pluripotency: Nanoinjection Into Human iPSCs

Advanced Materials, EarlyView.
Nanoinjection into hiPSCs: silicon nanotubes effectively transfect human induced pluripotent stem cells (hiPSCs) with mRNA, enabled by a delayed extracellular matrix application and enhanced surface functionalization. Nanoinjection is demonstrated with several reporter mRNA, including co‐transfection of mCherry and GFP.
Jann Harberts, Vuong Thi Thanh Xuan Ho, Yuqi Yang, Yuan Jiang, Roey Elnathan, Nicolas H. Voelcker   +5 more
wiley   +1 more source