Results 11 to 20 of about 59,237 (269)
The iPSC perspective on schizophrenia [PDF]
Trends in Neurosciences, 2022 Over a decade of schizophrenia research using human induced pluripotent stem cell (iPSC)-derived neural models has provided substantial data describing neurobiological characteristics of the disorder in vitro. Simultaneously, translation of the results into general mechanistic concepts underlying schizophrenia pathophysiology has been trailing behind ...
Noora Räsänen +4 more
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Genome Biology, 2014 AbstractThe probabilistic behavior of direct induction of pluripotency has been a subject of intense research interest. Here we discuss recently published reports on this topic.
Zviran, Asaf, Hanna, Jacob H
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Generation of donor organs in chimeric animals via blastocyst complementation
Вавиловский журнал генетики и селекции, 2020 The lack of organs for transplantation is an important problem in medicine today. The growth of organs in chimeric animals may be the solution of this.
T. I. Babochkina +2 more
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Determination of tsunami run-up and golden time in the megathrust subduction zone of the sunda strait segment [PDF]
E3S Web of Conferences, 2021 The Indonesian Disaster Data and Information Management Database state that the tsunami in the Megathrust Subduction Zone of the Sunda Strait Segment is a disaster threat with high impact and loss of life every time it occurs.
Sarikanti Ponangsera Iko +3 more
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Overcoming iPSC Obstacles [PDF]
Cell Stem Cell, 2016 We asked six leaders in the reprogramming field to share their views on remaining gaps in our scientific understanding of iPSCs that will need to be addressed to achieve their clinical promise. Their insights echo many issues raised in the Review by Tapia and Scholer in this issue.
Wernig, M., Götz, M., Eto, K.
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Pluripotent Stem Cell-Based Models: A Peephole into Virus Infections during Early Pregnancy
Cells, 2020 The rubella virus (RV) was the first virus shown to be teratogenic in humans. The wealth of data on the clinical symptoms associated with congenital rubella syndrome is in stark contrast to an incomplete understanding of the forces leading to the ...
Claudia Claus +2 more
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CiRA iPSC seed stocks (CiRA's iPSC Stock Project)
Stem Cell Research, 2021 In Japan, induced pluripotent stem cell (iPSC) Stock Project has started from 2013. The goal of the Project is to manufacture and release clinical-grade HLA homozygous iPSC lines that can cover almost the entire of Japanese population. We show the summary of the cell lines distributed, test results for quality control and future plans.
Tadaaki Hanatani, Naoko Takasu
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Biology Open, 2020 Human induced pluripotent stem cell (iPSC) technology has opened exciting opportunities for stem-cell-based therapy. However, its wide adoption is precluded by several challenges including low reprogramming efficiency and potential for malignant ...
Zhen Yu +11 more
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mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells
Disease Models & Mechanisms, 2019 Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive.
Robert A. Brown +8 more
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Cells, 2020 Induced pluripotent stem cells (iPSC) have been the focus of several studies due to their wide range of application, including in cellular therapy. The use of iPSC in regenerative medicine is limited by their tumorigenic potential. Extracellular vesicles
Federica Collino +12 more
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