Results 41 to 50 of about 88,697 (303)

DNA methylation patterns in human iPSC-derived sensory neuronal differentiation

Epigenetics, 2019
Sensory neurons of the peripheral nervous system are critical in health and disease. Sensory neurons derived from induced pluripotent stem (iPS) cells are now being used increasingly for in vitro models of neuropathy, pain, and neurotoxicity.
Soneela Ankam, Amandine Rovini, Saurabh Baheti, Ron Hrstka, Yanhong Wu, Kiley Schmidt, Hailong Wang, Nicolas Madigan, Lena-Sophie Koenig, Kimberly Stelzig, Zachary Resch, Christopher J. Klein, Zhifu Sun, Nathan P. Staff   +13 more
doaj   +1 more source

Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes

Disease Models & Mechanisms, 2019
Schimke immuno-osseous dysplasia is an autosomal recessive genetic osteochondrodysplasia characterized by dysmorphism, spondyloepiphyseal dysplasia, nephrotic syndrome and frequently T cell immunodeficiency.
Giusj Monia Pugliese, Federico Salaris, Valentina Palermo, Veronica Marabitti, Nicolò Morina, Alessandro Rosa, Annapaola Franchitto, Pietro Pichierri   +7 more
doaj   +1 more source

Development of an Arrhythmogenic Cardiomyopathy Model Using CRISPR-Cas9 and Homology-Directed Repair

Український журнал серцево-судинної хірургії
Arrhythmogenic cardiomyopathy (ACM) frequently results from loss-of-function variants in PKP2, leading to desmosomal failure, electrical instability, and fibrofatty remodeling.
Svetlana M. Gramatiuk, Sergii I. Estrin, Yulia V. Ivanova, Tatiana V. Kravchenko, Emily Hubbard, Karine Sargsyan   +5 more
doaj   +1 more source

Numerical investigation on the effect of blunt body deflector on darieus turbine performance [PDF]

E3S Web of Conferences
One of the renewable energy source that is abundant but has not been used optimally is wind energy. Roads are currently the main transportation infrastructure along with the increasing number of motorized vehicles.
Rofi’i Ahmad Syafiq, Aulia Aditia, Fadri Muhammad Ferry, Syarif Muhammad Haidar, Rahman Elvira Rosmawati, Haryadi Gunawan Dwi   +5 more
doaj   +1 more source

Minicircles for Investigating and Treating Arthritic Diseases

Pharmaceutics, 2021
Gene delivery systems have become an essential component of research and the development of therapeutics for various diseases. Minicircles are non-viral vectors with promising characteristics for application in a variety of fields.
Yeri Alice Rim, Yoojun Nam, Narae Park, Ji Hyeon Ju   +3 more
doaj   +1 more source

iPSC CRISPR-Cas9 engineered lines.

, 2022
iPSC CRISPR-Cas9 engineered lines.
Ryan Walters (266555), Katie Williams (6166097), Simote T. Foliaki (11548933), Bradley R. Groveman (11548936), Jue Yuan (391711), Karin Peterson (14020012), Anna Smith (3175848), Clayton Winkler (14020009), Cathryn L. Haigh (781205), Wenquan Zou (756803)   +9 more
core   +1 more source

Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells

Stem Cell Research & Therapy, 2018
Background Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo.
Yena Kim, Narae Park, Yeri Alice Rim, Yoojun Nam, Hyerin Jung, Kijun Lee, Ji Hyeon Ju   +6 more
doaj   +1 more source

Characterization of Early-Onset Finger Osteoarthritis-Like Condition Using Patient-Derived Induced Pluripotent Stem Cells

Cells, 2021
Early osteoarthritis (OA)-like symptoms are difficult to study owing to the lack of disease samples and animal models. In this study, we generated induced pluripotent stem cell (iPSC) lines from a patient with a radiographic early-onset finger ...
Yeri Alice Rim, Yoojun Nam, Narae Park, Kijun Lee, Hyerin Jung, Seung Min Jung, Jennifer Lee, Ji Hyeon Ju   +7 more
doaj   +1 more source

Pro-maturational effects of human iPSC-derived cortical astrocytes upon iPSC-derived cortical neurons [PDF]

, 2020
Astrocytes influence neuronal maturation and function by providing trophic support, regulating the extracellular environment, and modulating signaling at synapses.
Webber, Caleb, Whiteley, Emma S., Akerman, Colin J., Monzón-Sandoval, Jimena, Newey, Sarah E., Hedegaard, Anne   +5 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source