Results 41 to 50 of about 116,955 (355)
DNA methylation patterns in human iPSC-derived sensory neuronal differentiation
Epigenetics, 2019 Sensory neurons of the peripheral nervous system are critical in health and disease. Sensory neurons derived from induced pluripotent stem (iPS) cells are now being used increasingly for in vitro models of neuropathy, pain, and neurotoxicity.
Soneela Ankam +13 more
doaj +1 more source
Disease Models & Mechanisms, 2019 Schimke immuno-osseous dysplasia is an autosomal recessive genetic osteochondrodysplasia characterized by dysmorphism, spondyloepiphyseal dysplasia, nephrotic syndrome and frequently T cell immunodeficiency.
Giusj Monia Pugliese +7 more
doaj +1 more source
Monitoring and analysis of seismic data during the 2018 sunda strait tsunami [PDF]
E3S Web of Conferences, 2021 The tsunami of Sunda Strait occurred on December 22, 2018, at 21:03 West Indonesia Time (zone). An eruption of Mount Anak Krakatau caused an eruption that triggered a landslide on the slopes of Mount Anak Krakatau covering an area of 64 hectares that hit
Kurniawan Wahyu +4 more
doaj +1 more source
Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems [PDF]
, 2015 The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Barzon, Luisa +6 more
core +2 more sources
Numerical investigation on the effect of blunt body deflector on darieus turbine performance [PDF]
E3S Web of ConferencesOne of the renewable energy source that is abundant but has not been used optimally is wind energy. Roads are currently the main transportation infrastructure along with the increasing number of motorized vehicles.
Rofi’i Ahmad Syafiq +5 more
doaj +1 more source
Endothelial cells derived from patients' induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A. [PDF]
, 2020 Hemophilia A (HA) is a bleeding disorder characterized by spontaneous and prolonged hemorrhage. The disease is caused by mutations in the coagulation factor 8 gene (F8) leading to factor VIII (FVIII) deficiency.
Agu, Emmanuel +9 more
core +1 more source
Development of an Arrhythmogenic Cardiomyopathy Model Using CRISPR-Cas9 and Homology-Directed Repair
Український журнал серцево-судинної хірургіїArrhythmogenic cardiomyopathy (ACM) frequently results from loss-of-function variants in PKP2, leading to desmosomal failure, electrical instability, and fibrofatty remodeling.
Svetlana M. Gramatiuk +5 more
doaj +1 more source
Cells, 2021 Early osteoarthritis (OA)-like symptoms are difficult to study owing to the lack of disease samples and animal models. In this study, we generated induced pluripotent stem cell (iPSC) lines from a patient with a radiographic early-onset finger ...
Yeri Alice Rim +7 more
doaj +1 more source
Systematic optimization of human pluripotent stem cells media using Design of Experiments. [PDF]
, 2015 Human pluripotent stem cells (hPSC) are used to study the early stages of human development in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of disease.
Chailangkarn, Thanathom +2 more
core +1 more source
Stem Cell Research & Therapy, 2018 Background Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo.
Yena Kim +6 more
doaj +1 more source