Results 21 to 30 of about 116,955 (355)
Biology Open, 2020 Human induced pluripotent stem cell (iPSC) technology has opened exciting opportunities for stem-cell-based therapy. However, its wide adoption is precluded by several challenges including low reprogramming efficiency and potential for malignant ...
Zhen Yu +11 more
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mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells
Disease Models & Mechanisms, 2019 Bi-allelic GBA1 mutations cause Gaucher's disease (GD), the most common lysosomal storage disorder. Neuronopathic manifestations in GD include neurodegeneration, which can be severe and rapidly progressive.
Robert A. Brown +8 more
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Cells, 2020 Induced pluripotent stem cells (iPSC) have been the focus of several studies due to their wide range of application, including in cellular therapy. The use of iPSC in regenerative medicine is limited by their tumorigenic potential. Extracellular vesicles
Federica Collino +12 more
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Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]
, 2016 Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia +17 more
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Earthquake and tsunami potential levels in Sulawesi (lesson learned earthquake West Sulawesi) [PDF]
E3S Web of Conferences, 2021 Earthquake and tsunami disasters always bring negative impacts and losses for humans. The high frequency of earthquake disasters in Sulawesi and the massive impact of destruction and damage to infrastructure, loss of homes and property, and death of ...
Khoirudin Apriyadi Rio +3 more
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Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages [PDF]
International Journal of Molecular Sciences, 2020 Induced pluripotent stem cells (iPSCs) offer great promise for the field of regenerative medicine, and iPSC-derived cells have already been applied in clinical practice. However, potential contamination of effector cells with residual pluripotent cells (e.g., teratoma-initiating cells) or effector cell-associated side effects may limit this approach ...
Alexandra Lipus +11 more
openaire +3 more sources
Phenotyping Neurodegeneration in Human iPSCs [PDF]
Annual Review of Biomedical Data Science, 2021 Induced pluripotent stem cell (iPSC) technology holds promise for modeling neurodegenerative diseases. Traditional approaches for disease modeling using animal and cellular models require knowledge of disease mutations. However, many patients with neurodegenerative diseases do not have a known genetic cause.
Li, Jonathan, Fraenkel, Ernest
openaire +4 more sources
Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. [PDF]
, 2016 Great progress has been made regarding the capabilities to modify somatic cell fate ever since the technology for generation of induced pluripotent stem cells (iPSCs) was discovered in 2006.
Biswas, Sangita +3 more
core +6 more sources
Stem Cell Research, 2020 Human pluripotent stem cells offer a limitless source of cells for regenerative medicine. They are also highly valuable as tools to study development and pathologies or as cellular substrates to screen and test new drugs.
Eddy Quelennec +5 more
doaj +1 more source
Model system dynamics potential impact of disasters due to the re-period of the October 25th, 2010 earthquake in the Mentawai Islands [PDF]
E3S Web of Conferences, 2021 Geographically, the Mentawai Islands Regency has a territorial boundary with the sea. The north side is the Siberut Strait, the south side is bordered by the Indian Ocean, the east side is bordered by the Mentawai Strait, and the west side is bordered by
Aprilyanto +3 more
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