Results 31 to 40 of about 59,069 (269)
Molecular Therapy, 2011 The advent of induced pluripotent stem cell (iPSC) technology holds great promise to revolutionize personalized cell-based therapies.1,2,3,4,5 Recent advances in gene transfer technology therefore open up exciting possibilities for efficient and safe genetic modification of autologous cells in this context.6 As potential therapeutic applications are ...
Mukherjee, Sayandip, Thrasher, Adrian J
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DNA methylation patterns in human iPSC-derived sensory neuronal differentiation
Epigenetics, 2019 Sensory neurons of the peripheral nervous system are critical in health and disease. Sensory neurons derived from induced pluripotent stem (iPS) cells are now being used increasingly for in vitro models of neuropathy, pain, and neurotoxicity.
Soneela Ankam +13 more
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Disease Models & Mechanisms, 2019 Schimke immuno-osseous dysplasia is an autosomal recessive genetic osteochondrodysplasia characterized by dysmorphism, spondyloepiphyseal dysplasia, nephrotic syndrome and frequently T cell immunodeficiency.
Giusj Monia Pugliese +7 more
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Monitoring and analysis of seismic data during the 2018 sunda strait tsunami [PDF]
E3S Web of Conferences, 2021 The tsunami of Sunda Strait occurred on December 22, 2018, at 21:03 West Indonesia Time (zone). An eruption of Mount Anak Krakatau caused an eruption that triggered a landslide on the slopes of Mount Anak Krakatau covering an area of 64 hectares that hit
Kurniawan Wahyu +4 more
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Numerical investigation on the effect of blunt body deflector on darieus turbine performance [PDF]
E3S Web of ConferencesOne of the renewable energy source that is abundant but has not been used optimally is wind energy. Roads are currently the main transportation infrastructure along with the increasing number of motorized vehicles.
Rofi’i Ahmad Syafiq +5 more
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Development of an Arrhythmogenic Cardiomyopathy Model Using CRISPR-Cas9 and Homology-Directed Repair
Український журнал серцево-судинної хірургіїArrhythmogenic cardiomyopathy (ACM) frequently results from loss-of-function variants in PKP2, leading to desmosomal failure, electrical instability, and fibrofatty remodeling.
Svetlana M. Gramatiuk +5 more
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Stem Cell Research & Therapy, 2018 Background Skin is an organ that plays an important role as a physical barrier and has many other complex functions. Skin mimetics may be useful for studying the pathophysiology of diseases in vitro and for repairing lesions in vivo.
Yena Kim +6 more
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Inducing iPSCs to Escape the Dish [PDF]
Cell Stem Cell, 2011 Induced pluripotent stem cells (iPSCs) hold great promise for autologous cell therapies, but significant roadblocks remain to translating iPSCs to the bedside. For example, concerns about the presumed autologous transplantation potential of iPSCs have been raised by a recent paper demonstrating that iPSC-derived teratomas were rejected by syngeneic ...
Barrilleaux, Bonnie, Knoepfler, Paul S.
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The application of iPSCs in Parkinson’s disease [PDF]
Acta Neurobiologiae Experimentalis, 2020 The discovery and application of induced pluripotent stem cells (iPSCs) provide a novel treatment modality for diseases, which remain incurable. Particularly, in the treatment of neurodegenerative diseases such as Parkinson's disease (PD), iPSC‑technology holds an interesting prospect for replacement therapy. Currently, the prognostic improvement of PD
Nielsen, Josefine Jul Jarbæk +4 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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