Results 51 to 60 of about 88,697 (303)

iPSC-derived neurons repress HIV expression.

, 2019
(A) 60,000 hμglia/HIV HC69 cells were plated in the presence of 0.5 x 106 LUHMES-derived neurons (as positive control) or 0.5 x 106 iPSC-derived GABAergic cortical (iCort), dopaminergic (iDopaNer) or motor neurons (iMotorNer).
Kurt F. Hauser (8201931), David Alvarez-Carbonell (3721597), Jonathan Karn (220557), Fengchun Ye (164906), Nirmala Ramanath (8201925), Yoelvis Garcia-Mesa (3721603), Pamela E. Knapp (8201928)   +6 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Comparative analysis of proteins between AD-iPSCs and AD-iPSC-derived neurons after wortmannin treatment.

, 2016
Protein lysates of AD-iPSCs and iPSC-derived neurons (INC) were analyzed after treatment with 4μM wortmannin for different times. Fourty μg of protein each were separated by SDS-PAGE (12%).
Christos C. Zouboulis (114304), Annika S. Quast (2637112), Katharina Grauel (2565052), Judit Küchler (2565058), Tarik Exner (2565046), Michael Plötz (326888), Harald Stachelscheid (2565064), Evgenia Makrantonaki (114279), Amir M. Hossini (114292), Jürgen Eberle (285297), Anja Rabien (2565049)   +10 more
core   +1 more source

Implementing iPSC Technology: Case studies of iPSC-tissue cell use in disease modeling and drug discovery

, 2018
Case studies on deriving iPSCs from clinical and non-clinical populations and using iPSC-tissue cells in disease modeling and drug discovery.Induced pluripotent stem cell (iPSC) technology is having a positive impact on drug discovery efforts through ...
Blake Anson (5246761)
core   +2 more sources

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Characterization of iPSC clones.

, 2013
(A) Representative immunofluorescence of pluripotency markers in human iPSC clones derived from CD34+ CB cells (CB-iPSC #11) and CD34+ from CML first patient (CML-iPSCs #1.22, #1.24 and #1.31) and from CML second patient (#2.1 and #2.2), staining with ...
Jean- Max Pasquet (449906), Emmanuel Richard (447819), François Beliveau (449910), Sandrine Dabernat (225302), Valérie Lagarde (449908), Aurélie Bedel (393477), Éric Lippert (5656039), Hubert de Verneuil (449911), Pierre Dubus (225300), François Moreau-Gaudry (449912), Miguel Taillepierre (449907), Lucie Charaf (449909), François-Xavier Mahon (372886)   +12 more
core   +1 more source

Multimode Oxide‐Based Optoelectronic Memtransistor for In‐Sensor Vision Processing

Advanced Functional Materials, EarlyView.
A multimode optoelectronic memtransistor (OEMT) is demonstrated for vision explainable artificial intelligence (VXAI) hardware. By integrating optical sensing, electrical masking, and non‐volatile memory, the device enables key operations required for generating saliency information.
Min Gu Lee, Geunyoung Kim, Hwa Young Kim, Do Hoon Kim, Hanchan Song, Huisu Noh, Jungwan Noh, Seungwoo Lee, Sang‐Hee Ko Park, Himchan Cho, Kyung Min Kim   +10 more
wiley   +1 more source

Human iPSC-derived fetal granulosa-like cells enhance oocyte maturation outcomes and enable multi-generational safety evaluation in a mouse IVM model

The Journal of Reproduction and Development
In vitro maturation (IVM) of germinal vesicle oocytes may broaden assisted reproductive technologies; however, developmental competence remains limited by the lack of standardized follicular somatic support. We generated an endogenous
Kasane IMURA-KISHI, Katsuma YAMAGA, Shou SOEDA, Keisuke MASUDA, Yuki MIZOUE, Reiri KOGA, Daisuke TORIGOE, Hiroki MIYAZAKI, Iori SATO, Orie HIKABE, Kazuaki KOJIMA, Toru TAKEO, Nobuhiko HAMAZAKI, Yasunari SEITA   +13 more
doaj   +1 more source

Inducing iPSCs to Escape the Dish [PDF]

Cell Stem Cell, 2011
Induced pluripotent stem cells (iPSCs) hold great promise for autologous cell therapies, but significant roadblocks remain to translating iPSCs to the bedside. For example, concerns about the presumed autologous transplantation potential of iPSCs have been raised by a recent paper demonstrating that iPSC-derived teratomas were rejected by syngeneic ...
Barrilleaux, Bonnie, Knoepfler, Paul S.
openaire   +2 more sources

Pathway analysis for differentially expressed genes (uncorrected) T-iPSC neurons vs F-iPSC neurons.

, 2013
Pathway analysis for differentially expressed genes (uncorrected) T-iPSC neurons vs F-iPSC neurons.
Anastasia Hrabovsky (139067), Mingyan Lin (139065), Herbert M. Lachman (139079), John J. Foxe (266687), Erika Pedrosa (139072), Deyou Zheng (7943), Reed Carroll (466150), Jian Chen (15340)   +7 more
core   +1 more source