Results 61 to 70 of about 898 (115)

Severe hemolysis flare of refractory autoimmune hemolytic anemia with positive complement component C3d responsive to Iptacopan with cyclophosphamide and prednisone: a case report

Hematology
Objectives: Autoimmune hemolytic anemia (AIHA) is characterized by autoimmune-mediated destruction of erythrocytes. Both AIHA and Evans syndrome are rare, manifesting a severe clinical course, high relapse rate, and potentially fatal outcomes. Refractory
Yawen Zhang, Yuemin Gong, Guangsheng He
doaj   +1 more source

Efficacy of Immunosuppression Therapy in Primary IgA Nephropathy in Adults: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Journal of Clinical Question
Introduction: Immunosuppressive therapy for primary IgA nephropathy (IgAN) remains controversial, particularly with the emergence of novel agents targeting specific pathogenic pathways. Therefore, this study aimed to evaluate the comparative efficacy and
Guihua Gao, Yoshihito Iida, Chadia Beaini, Ali Ghanem, Sandeep Varma, Magdy Elsharkawy   +5 more
doaj   +1 more source

The Complement System: An Important New Therapeutic Target in IgA Nephropathy

Glomerular Diseases
Background: IgA nephropathy is the most common primary glomerular disease worldwide, and it is an important cause of end-stage kidney disease.
Karshana J. Kalyanaraman, Joshua M. Thurman   +1 more
doaj   +1 more source

Eficacia de iptacopán en glomerulonefritis membranoproliferativa por inmunocomplejos idiopática refractaria al tratamiento convencional

Nefrología
Resumen: La glomerulonefritis membranoproliferativa por inmunocomplejos (GNMP-IC) idiopática es un diagnóstico de exclusión una vez descartados los procesos etiológicos más frecuentes asociados a este patrón de daño glomerular (infecciosos, enfermedades ...
Raquel López Hidalgo, Mercedes Caba Molina, Francisco Javier Ruiz Escolano, Elena Delgado Sánchez de Murga, Ma Teresa Fernández Quirós, Ma José Espigares Huete   +5 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Efficacy of iptacopan in idiopathic immune complex–mediated membranoproliferative glomerulonephritis refractory to conventional treatment

Nefrología (English Edition)
Membranoproliferative glomerulonephritis due to immune complexes (MPGN-IC) idiopathic is a diagnosis of exclusion, made after ruling out the most common etiological processes associated with this pattern of glomerular injury (infectious, autoimmune ...
Raquel López Hidalgo, Mercedes Caba Molina, Francisco Javier Ruiz Escolano, Elena Delgado Sánchez de Murga, Maria Teresa Fernández Quirós, Maria José Espigares Huete   +5 more
doaj   +1 more source

The Advancing Landscape of Paroxysmal Nocturnal Hemoglobinuria Treatment

Turkish Journal of Hematology
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare chronic bone marrow failure condition characterized by complement-mediated hemolytic anemia and thrombosis.
Cameron Perry, Xinyu Von Buttlar, Swapna Thota   +2 more
doaj   +1 more source

Psychometric performance of the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue questionnaire among adults with paroxysmal nocturnal hemoglobinuria

Journal of Patient-Reported Outcomes
Background Two Phase 3 clinical trials were conducted to investigate the efficacy and safety of iptacopan, a novel treatment for paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired hemolytic disorder whose most prevalent symptom is fatigue.
David Cella, Susan Vallow, Georgina Bermann, Jeffrey McDonald, Gilbert Ngerano, Samantha Linton, Ethan Arenson, Samopriyo Maitra, Glorian Yen, Nina Galipeau, Gavin Dickie   +10 more
doaj   +1 more source

Immunoglobulin A Nephropathy: Molecular Pathogenesis and Targeted Therapy

MedComm
Immunoglobulin A nephropathy (IgAN), the most prevalent primary glomerulonephritis globally, is characterized by mesangial IgA deposition and heterogeneous clinical trajectories.
Xu‐Jie Zhou
doaj   +1 more source