Results 81 to 90 of about 4,432 (206)

Investigating a Domain Adaptation Approach for Integrating Different Measurement Instruments in a Longitudinal Clinical Registry

open access: yesBiometrical Journal, Volume 67, Issue 1, February 2025.
ABSTRACT In a longitudinal clinical registry, different measurement instruments might have been used for assessing individuals at different time points. To combine them, we investigate deep learning techniques for obtaining a joint latent representation, to which the items of different measurement instruments are mapped.
Maren Hackenberg   +5 more
wiley   +1 more source

Systematic reviews of health economic evaluations: a protocol for a systematic review of characteristics and methods applied

open access: yesSystematic Reviews, 2017
Background The number of systematic reviews of economic evaluations is steadily increasing. This is probably related to the continuing pressure on health budgets worldwide which makes an efficient resource allocation increasingly crucial.
Miriam Luhnen   +3 more
doaj   +1 more source

Cost-effectiveness of managing cavitated primary molar caries lesions:A randomized trial in Germany [PDF]

open access: yes, 2018
The Hall Technique (HT), Non-Restorative Cavity Control (NRCC) and conventional carious tissue removal and restoration (CR) are strategies for managing cavitated caries lesions in primary molars.
Innes, Nicola   +6 more
core   +2 more sources

Imaginary Worlds and Efficiency Frontiers: Should We Abandon the IQWiG Health Technology Assessment Model?

open access: yesINNOVATIONS in Pharmacy, 2017
The contribution of cost-effectiveness analysis to the pricing of pharmaceuticals in Germany is at best marginal and in many, if not most cases, absent.
Paul C Langley
doaj   +1 more source

Time to review the role of surrogate endpoints in health policy: state of the art and the way forward [PDF]

open access: yes, 2017
The efficacy of medicines, medical devices, and other health technologies should be proved in trials that assess final patient-relevant outcomes such as survival or morbidity.
Buyse, M.   +5 more
core   +2 more sources

Epidemiology and reporting characteristics of overviews of reviews of healthcare interventions published 2012–2016: protocol for a systematic review

open access: yesSystematic Reviews, 2017
Background Overviews of systematic reviews (overviews) attempt to systematically retrieve and summarize the results of multiple systematic reviews (SRs) for a given condition or public health problem.
Dawid Pieper   +4 more
doaj   +1 more source

HC4 The Potential Impact Of Recommendations Made Through The Common Drug Review Program At The Canadian Agency For Drugs And Technologies In Health [PDF]

open access: yes, 1990
A full-length cDNA clone specifying the nuclear-encoded subunit VIb of human cytochrome c oxidase (COX) was isolated from a human skeletal muscle cDNA expression library. This was done with antiserum directed against the group of subunits VIa, b and c of
AGSTERIBBE, E   +6 more
core   +2 more sources

„Wir müssen gemessene Werte stärker mit PRO verknüpfen”

open access: yesMonitor Versorgungsforschung
Die unterschiedliche Nutzenbewertung von Pembrolizumab („Keytruda”) durch das IQWiG und die ESMO, auf die Institutsleiter Dr. med. Thomas Kaiser im „Monitor-Versorgungsforschung”-Titelinterview der Ausgabe 02/25 einging, wirft grundlegende Fragen zur ...
Prof. Dr. Reinhold Roski   +2 more
doaj   +1 more source

Challenges and methodologies in using progression free survival as a surrogate for overall survival In oncology [PDF]

open access: yes, 2018
Objectives: A primary outcome in oncology trials is overall survival (OS). However, to estimate OS accurately requires a sufficient number of patients to have died, which may take a long time. If an alternative end point is sufficiently highly correlated
Fischer, A.   +2 more
core   +1 more source

Evidence-based indications for the planning of PET or PET/CT capacities are needed [PDF]

open access: yes, 2019
Purpose To identify evidence-based indications for PET/PET–CT scans in support of facilities planning and to describe a pilot project in which this information was applied for an investment decision in an Austrian region.
Busse, Reinhard   +4 more
core   +1 more source

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