Results 61 to 70 of about 2,073 (215)

Systemic therapy in children and adolescents with mental disorders: a systematic review and meta-analysis

BMC Psychiatry
Background Systemic therapy (ST) is a psychotherapeutic intervention in complex human systems (both psychological and interpersonal). Cognitive behavioural therapy (CBT) is an established treatment for children and adolescents with mental disorders.
David Henry Seidel, Martina Markes, Ulrich Grouven, Claudia-Martina Messow, Wiebke Sieben, Marco Knelangen, Rieke Oelkers-Ax, Sebastian Grümer, Heike Kölsch, Mandy Kromp, Markus von Pluto Prondzinski   +10 more
doaj   +1 more source

Event‐free survival and complete response rate as surrogate endpoints for overall survival in high‐risk non–muscle‐invasive bladder cancer: A meta‐analysis of bacillus Calmette‐Guérin—naive or —remote cases

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Event‐free survival (EFS) and complete response rate (CRR) are recommended as primary endpoints in bladder cancer trials to enable timely assessment of therapeutic benefit. However, their surrogacy relationship with overall survival (OS) in high‐risk non–muscle‐invasive bladder cancer (HR NMIBC) remains unclear.
Rituparna Bhattacharya, Kalé Kponee‐Shovein, Yipeng Gao, Yan Song, Jingyi Liu, Katherine Wei, Ekta Kapadia, Haojie Li, Ashish M. Kamat   +8 more
wiley   +1 more source

Cost‐Effectiveness Analysis of Risky Health Interventions: Moving Beyond Risk Neutrality

Ratio, Volume 38, Issue 4, Page 219-227, December 2025.
ABSTRACT Cost‐effectiveness analysis for health interventions is traditionally conducted in a risk‐neutral way, insensitive to risk attitudes in the population, which are potentially non‐neutral. While the standard outcome metric of quality‐adjusted life years (QALYs) aims to be deferential to people's valuations of health states, cost‐effectiveness ...
Johanna Thoma
wiley   +1 more source

Disagreement in primary study selection between systematic reviews on negative pressure wound therapy

BMC Medical Research Methodology, 2008
Background Primary study selection between systematic reviews is inconsistent, and reviews on the same topic may reach different conclusions. Our main objective was to compare systematic reviews on negative pressure wound therapy (NPWT) regarding their ...
Sauerland Stefan, McGauran Natalie, Peinemann Frank, Lange Stefan   +3 more
doaj   +1 more source

Möglichkeiten der Beteiligung der Fachgesellschaften an der Berichterstellung des IQWiG [PDF]

, 2007
Im GKV-Wettbewerbsstärkungsgesetz (GKV-WSG) ist die Einbeziehung des wissenschaftlichen medizinischen Sachverstandes an zwei Stellen besonders hervorgehoben: bei der Bestimmung der Inhalte für die Umsetzung der Qualitätssicherung und der Darstellung der
Selbmann, HK
core  

Treatment effects in orthopaedic trials are underestimated by applying patient‐level PRO thresholds for meaningful differences at the group level

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 11, Page 3739-3743, November 2025.
Abstract Orthopaedic trials frequently rely on patient‐reported outcomes (PROs) to measure primary end points. Thresholds for clinically meaningful score differences are then used to interpret PRO scores and support result interpretation. At the patient level, thresholds are used to determine if an individual patient has experienced a clinically ...
David F. Hamilton, Karlmeinrad Giesinger, Johannes M. Giesinger   +2 more
wiley   +1 more source

Cost effectiveness analysis of prostate cancer screening strategies in Germany: A microsimulation study

International Journal of Cancer, Volume 157, Issue 8, Page 1662-1679, 15 October 2025.
What's New? Prostate cancer is a significant health and economic concern in Germany. In particular, screening methods require greater optimisation to prevent overdiagnosis and unnecessary procedures and to ensure clinical benefit. Here, prostate cancer screening strategies were evaluated to determine which are most effective in terms of cost and health
Muchandifunga Trust Muchadeyi, Shuang Hao, Karla Hernandez‐Villafuerte, Shah Alam Khan, Nikolaus Becker, Agne Krilaviciute, Petra Seibold, Roman Gulati, Peter Albers, Michael Schlander, Mark Clements   +10 more
wiley   +1 more source

Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2017
Background: Progression-free survival (PFS) is often used instead of the patient-relevant endpoint overall survival (OS) in cancer clinical trials.
Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm   +3 more
doaj   +1 more source

Proposing a Coverage With Evidence Development Framework for Accelerated Approval at the U.S. Food and Drug Administration

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
Dhanush Bearelly, Purav Desai, David T. Zhu, Rajesh Balkrishnan   +3 more
wiley   +1 more source

Hazards, Causality, and Practical Relevance of Collider Effects – Comment on Beyersmann et al. “Hazards Constitute Key Quantities for Analyzing, Interpreting and Understanding Time‐to‐Event Data”

Biometrical Journal, Volume 67, Issue 5, October 2025.
ABSTRACT Hazards constitute key quantities for analyzing, interpreting, and understanding time‐to‐event data. Hazards and corresponding effect measures, such as the hazard ratio from the Cox proportional hazards model, have a valid causal interpretation if the hazard function is considered as a function in time rather than hazards at specific time ...
Ralf Bender, Lars Beckmann
wiley   +1 more source