Results 61 to 70 of about 2,068 (215)

Stellungnahme der AG Methoden der gesundheitsökonomischen Evaluation (AG MEG) zu dem Methodenpapier 'Methodik für die Bewertung von Verhältnissen zwischen Nutzen und Kosten im System der deutschen gesetzlichen Krankenversicherung' d [PDF]

, 2008
Mit dem Wettbewerbsstärkungsgesetz von April 2007 kann das Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) vom Gemeinsamen Bundesausschuss (G-BA) mit der Kosten-Nutzen-Bewertung von Arzneimitteln beauftragt werden.
Brüggenjürgen, B., Rothgang, H., Schweikert, B., Krauth, C., John, J., Hansmeier, T., Kohlmann, T., Wasem, J., Hessel, F., Aidelsburger, P., Moock, J., Seitz, R.   +11 more
core   +1 more source

Systemic therapy in children and adolescents with mental disorders: a systematic review and meta-analysis

BMC Psychiatry
Background Systemic therapy (ST) is a psychotherapeutic intervention in complex human systems (both psychological and interpersonal). Cognitive behavioural therapy (CBT) is an established treatment for children and adolescents with mental disorders.
David Henry Seidel, Martina Markes, Ulrich Grouven, Claudia-Martina Messow, Wiebke Sieben, Marco Knelangen, Rieke Oelkers-Ax, Sebastian Grümer, Heike Kölsch, Mandy Kromp, Markus von Pluto Prondzinski   +10 more
doaj   +1 more source

Cost effectiveness analysis of prostate cancer screening strategies in Germany: A microsimulation study

International Journal of Cancer, Volume 157, Issue 8, Page 1662-1679, 15 October 2025.
What's New? Prostate cancer is a significant health and economic concern in Germany. In particular, screening methods require greater optimisation to prevent overdiagnosis and unnecessary procedures and to ensure clinical benefit. Here, prostate cancer screening strategies were evaluated to determine which are most effective in terms of cost and health
Muchandifunga Trust Muchadeyi, Shuang Hao, Karla Hernandez‐Villafuerte, Shah Alam Khan, Nikolaus Becker, Agne Krilaviciute, Petra Seibold, Roman Gulati, Peter Albers, Michael Schlander, Mark Clements   +10 more
wiley   +1 more source

Disagreement in primary study selection between systematic reviews on negative pressure wound therapy

BMC Medical Research Methodology, 2008
Background Primary study selection between systematic reviews is inconsistent, and reviews on the same topic may reach different conclusions. Our main objective was to compare systematic reviews on negative pressure wound therapy (NPWT) regarding their ...
Sauerland Stefan, McGauran Natalie, Peinemann Frank, Lange Stefan   +3 more
doaj   +1 more source

Möglichkeiten der Beteiligung der Fachgesellschaften an der Berichterstellung des IQWiG [PDF]

, 2007
Im GKV-Wettbewerbsstärkungsgesetz (GKV-WSG) ist die Einbeziehung des wissenschaftlichen medizinischen Sachverstandes an zwei Stellen besonders hervorgehoben: bei der Bestimmung der Inhalte für die Umsetzung der Qualitätssicherung und der Darstellung der
Selbmann, HK
core  

Hazards, Causality, and Practical Relevance of Collider Effects – Comment on Beyersmann et al. “Hazards Constitute Key Quantities for Analyzing, Interpreting and Understanding Time‐to‐Event Data”

Biometrical Journal, Volume 67, Issue 5, October 2025.
ABSTRACT Hazards constitute key quantities for analyzing, interpreting, and understanding time‐to‐event data. Hazards and corresponding effect measures, such as the hazard ratio from the Cox proportional hazards model, have a valid causal interpretation if the hazard function is considered as a function in time rather than hazards at specific time ...
Ralf Bender, Lars Beckmann
wiley   +1 more source

Complex, low‐intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre‐schoolers with autism spectrum disorder: The multicentre, observer‐blind, parallel‐group randomised‐controlled A‐FFIP trial

Journal of Child Psychology and Psychiatry, Volume 66, Issue 10, Page 1500-1513, October 2025.
Background Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre‐school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low‐intensity, complex NDBI ‘Frankfurt Early Intervention Program for ASD’ (A‐FFIP) over 1 year by a confirmatory phase‐III, prospective ...
Christine M. Freitag, Marietta Kirchner, Lukas D. Sauer, Solvejg K. Kleber, Leonie Polzer, Naisan Raji, Christian Lemler, Ulrike Fröhlich, Tomasz Jarczok, Julia Geissler, Franziska Radtke, Melanie Ring, Veit Roessner, Regina Taurines, Michelle Noterdaeme, Karoline Teufel, Ziyon Kim, Janina Kitzerow‐Cleven   +17 more
wiley   +1 more source

Surrogatvalidierung durch Korrelation und Surrogate Threshold Effect – Ergebnisse von Simulationsstudien

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2017
Background: Progression-free survival (PFS) is often used instead of the patient-relevant endpoint overall survival (OS) in cancer clinical trials.
Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm   +3 more
doaj   +1 more source

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase‐IIa Randomized, Double‐Blind, Sham‐Controlled Feasibility Study

Autism Research, Volume 18, Issue 9, Page 1861-1876, September 2025.
ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham‐controlled, double‐blind parallel‐group Phase‐
Christina Luckhardt, Magdalena Schütz, Andreas M. Mühlherr, Sara Boxhoorn, Christine Ecker, Hanna Mössinger, Julia Siemann, Fabienne Schlechter, Miguel Castelo‐Branco, Helena C. Pereira, Marianne Latinus, Camille Ricou, Frederique Bonnet‐Brilhault, Ricardo Salvador, Giulio Ruffini, Rafal Nowak, Michael Siniatchkin, Astrid Dempfle, Christine M. Freitag   +18 more
wiley   +1 more source

„Stärkerer Fokus auf die Methoden der Studiendurchführung“

Monitor Versorgungsforschung
Nach Prof. Dr. med. Peter Sawicki (2004 bis 2009) und Prof. Dr. med. Jürgen Windeler (2010 bis März 2023) ist seit April 2023 Dr. med. Thomas Kaiser der dritte Leiter des Instituts für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG).
Dr. med. Thomas Kaiser, Peter Stegmaier
doaj   +1 more source