Results 51 to 60 of about 2,068 (215)

Tonsillectomy versus tonsillotomy for recurrent acute tonsillitis in children and adults (TOTO): study protocol for a randomized non-inferiority trial

Trials, 2021
Background Tonsillectomy is one of the most frequently performed surgeries in children and young adults worldwide. For decades, tonsillectomy was the surgical treatment of choice for recurrent acute tonsillitis. Tonsillotomy was used in some countries as
Orlando Guntinas-Lichius, Katharina Geißler, Thomas Asendorf, Ralf Tostmann, Jan Löhler   +4 more
doaj   +1 more source

Visual Search Performance in Children With ASD: A Combined Case‐Control and Longitudinal Study

Autism Research, Volume 19, Issue 6, June 2026.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with altered attentional function. This has been associated with enhanced visual search performance. Addressing a gap in the literature, we investigate the longitudinal development of visual search alongside ASD symptoms.
Naisan Raji, Iskra Todorova, Leonie Polzer, Solvejg K. Kleber, Christian Lemler, Luisa Schnettler, Janina Kitzerow‐Cleven, Ziyon Kim, Christine M. Freitag, Nico Bast   +9 more
wiley   +1 more source

Best Practices and Gaps in Current Regulatory and Health Technology Assessment Real‐World Evidence Policies for Medicines and Medical Devices: Current State of Play and Next Steps

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Real‐world data (RWD) offers a valuable opportunity to access vast information that can drive research and generate real‐world evidence (RWE), offering insights into the actual delivery of care and patient outcomes beyond the limitations of traditional clinical trials.
Katharine Cresswell, Ravinder Claire, Laila Issa, Luke Kubehl, Omnia Bilal, Rose Purcell, Amaya Clemente, Jakob Wested, Lotte Groth Jensen, Medha Sasane, Rita Peeters, Bethany Shinkins, Heather Colvin   +12 more
wiley   +1 more source

Méthodes d’évaluation économique de trois agences publiques d’évaluation des stratégies de santé (NICE, IQWiG et KCE) : quels fondements en matière de justice sociale ? [PDF]

, 2012
L’objectif de l’article est de comparer les méthodologies d’évaluation économique de trois agences publiques chargées d’apporter une aide à la décision en matière de définition du périmètre des soins remboursables : le NICE (Angleterre et Pays-de Galles),
Thébaut, Clémence
core   +1 more source

Event‐free survival and complete response rate as surrogate endpoints for overall survival in high‐risk non–muscle‐invasive bladder cancer: A meta‐analysis of bacillus Calmette‐Guérin—naive or —remote cases

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Event‐free survival (EFS) and complete response rate (CRR) are recommended as primary endpoints in bladder cancer trials to enable timely assessment of therapeutic benefit. However, their surrogacy relationship with overall survival (OS) in high‐risk non–muscle‐invasive bladder cancer (HR NMIBC) remains unclear.
Rituparna Bhattacharya, Kalé Kponee‐Shovein, Yipeng Gao, Yan Song, Jingyi Liu, Katherine Wei, Ekta Kapadia, Haojie Li, Ashish M. Kamat   +8 more
wiley   +1 more source

PP015 Methodological Quality Of Health Technology Assessment Reports [PDF]

, 2017
INTRODUCTION:Health Technology Assessment (HTA) reports may have a major impact on the health care provided in a country. Hence, one would assume that these reports have a high methodological quality and thus represent a potentially important source of ...
Siw Waffenschmidt, Elke Hausner, Marco Knelangen, Laura Sanders   +3 more
core   +1 more source

Generierung & Auswertung versorgungsnaher Daten

Monitor Versorgungsforschung
Im Januar dieses Jahres hat der Gemeinsame Bundesausschuss (G-BA) das Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) mit einer wissenschaftlichen Ausarbeitung zur Methodik bei der Generierung und Auswertung versorgungsnaher ...
Peter Stegmaier
doaj   +1 more source

Cost‐Effectiveness Analysis of Risky Health Interventions: Moving Beyond Risk Neutrality

Ratio, Volume 38, Issue 4, Page 219-227, December 2025.
ABSTRACT Cost‐effectiveness analysis for health interventions is traditionally conducted in a risk‐neutral way, insensitive to risk attitudes in the population, which are potentially non‐neutral. While the standard outcome metric of quality‐adjusted life years (QALYs) aims to be deferential to people's valuations of health states, cost‐effectiveness ...
Johanna Thoma
wiley   +1 more source

Interventions for reducing self-stigma in people with mental illnesses: a systematic review of randomized controlled trials

GMS German Medical Science, 2017
Background: Self-stigma occurs when people with mental illnesses internalize negative stereotypes and prejudices about their condition. It can reduce help-seeking behaviour and treatment adherence.
Büchter, Roland Brian, Messer, Melanie
doaj   +1 more source

Treatment effects in orthopaedic trials are underestimated by applying patient‐level PRO thresholds for meaningful differences at the group level

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 11, Page 3739-3743, November 2025.
Abstract Orthopaedic trials frequently rely on patient‐reported outcomes (PROs) to measure primary end points. Thresholds for clinically meaningful score differences are then used to interpret PRO scores and support result interpretation. At the patient level, thresholds are used to determine if an individual patient has experienced a clinically ...
David F. Hamilton, Karlmeinrad Giesinger, Johannes M. Giesinger   +2 more
wiley   +1 more source