Results 41 to 50 of about 2,068 (215)

HTA und aktuelle Herausforderungen: Harmonisierung, Real World Data und Surrogatparameter

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2018
Health Technology Assessment is one of the standard instruments in support of the decision-making to define the public health services both internationally and in the German health care system.
Rüther, Alric, Herrmann, Kirsten H., Hebborn, Ansgar, Perleth, Matthias, Schwarzer, Ruth, Schürmann, Christoph, Sieben, Wiebke, Gillhaus, Johanna, Goertz, Ralf, Jeratsch, Ulli, Leverkus, Friedhelm, Schramm, Wendelin   +11 more
doaj   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

IQWiG-Evidenzbericht zum Thema psychische Folgen eines Schwangerschaftsabbruchs [PDF]

<jats:title>Zusammenfassung</jats:title> <jats:p>Das Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) wurde vom Bundesministerium für Gesundheit beauftragt, bei der Weiterentwicklung der S2k-Leitlinie ...
Tasar, Andrea, Endres, David, Gowik, Julia   +2 more
core   +1 more source

Economic Evaluation and Transferability of Physical Activity Programmes in Primary Prevention: A Systematic Review [PDF]

, 2010
This systematic review aims to assess the characteristics of, and the clinical and economic evidence provided by, economic evaluations of primary preventive physical exercise interventions, and to analyse their transferability to Germany using ...
Wenig, C.M., Wolfenstetter, Wolfenstetter, Silke B., Wenig, Wenig, Christina M., Wolfenstetter, S.B.   +5 more
core   +1 more source

Policy Networks and Policy Entrepreneurship in the EU: Explaining Structural Policy Change in Pharmaceutical Innovation Incentives and Health Technology Assessment

European Policy Analysis, EarlyView.
ABSTRACT Policy process research has excelled in explaining structural policy change within national settings, but extensions and applications to the EU level have long proven challenging for scholars. Given that the EU is currently experiencing its longest period of Treaty stability since the 1980s—having evolved into a sui generis political system ...
Vassilis Karokis‐Mavrikos
wiley   +1 more source

Study filters for non-randomized studies of interventions consistently lacked sensitivity upon external validation

BMC Medical Research Methodology, 2018
Background Little evidence is available on searches for non-randomized studies (NRS) in bibliographic databases within the framework of systematic reviews.
Elke Hausner, Maria-Inti Metzendorf, Bernd Richter, Fabian Lotz, Siw Waffenschmidt   +4 more
doaj   +1 more source

Anwendungsbegleitende Datenerhebungen für die Nutzenbewertung von Arzneimitteln in Deutschland: Warum, wann und wie?

GMS Medizinische Informatik, Biometrie und Epidemiologie
For newly authorised medicinal products with new active substances, a benefit assessment is carried out at the time of their market access in Germany. The subject of this assessment is the question of the additional benefit of the new active substance ...
Kaiser, Thomas, Vervölgy, Volker
doaj   +1 more source

Quality ratings of reviews in overviews: a comparison of reviews with and without dual (co-)authorship

Systematic Reviews, 2018
Background Previous research shows that many authors of Cochrane overviews were also involved in some of the included systematic reviews (SRs). This type of dual (co-)authorship (DCA) may be a conflict of interest and a potential source of bias.
Dawid Pieper, Andreas Waltering, Jakob Holstiege, Roland Brian Büchter   +3 more
doaj   +1 more source

Attenuated selective attention during visual perspective taking in autism: A combined behavior, ERP, and pupillometry study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Altered social cognition in autism may be influenced by difficulties in domain‐general functions, such as selective attention. Here, we manipulated the requirement for selective attention during a visual perspective taking (VPT) task and used neurophysiological indices to delineate underlying mechanisms.
Leonie Polzer, Nico Bast, Sara Boxhoorn, Andreas Mühlherr, Hannah Mössinger, Magdalena Schütz, Christine M. Freitag, Christina Luckhardt   +7 more
wiley   +1 more source

Inconsistent trial assessments by the National Institute for Health and Clinical Excellence and IQWiG: standards for the performance and interpretation of subgroup analyses are needed. [PDF]

, 2010
OBJECTIVES: The methodology for the critical assessment of medical interventions is well established. Regulatory agencies and institutions adhere, in principle, to the same standards. This consistency, however, is not always the case in practice.
Bramlage, P, Hasford, J, Rothwell, PM, Lehmacher, W, Einhäupl, K, Koch, G, Rothwell, Peter   +6 more
core   +1 more source