Results 51 to 60 of about 22,781,794 (242)
Activator protein 1 promotes the transcriptional activation of IRAK-M
Biomedicine & Pharmacotherapy, 2016 Interleukin-1 receptor-associated kinase M (IRAK-M) is a well-known negative regulator for Toll-like receptor signaling, which can regulate immune homeostasis and tolerance in a number of pathological settings. However, the mechanism for IRAK-M regulation at transcriptional level remains largely unknown.
Peipei, Jin +6 more
openaire +2 more sources
Frontiers in Immunology, 2014 Chronic inflammation has long been associated with the development of cancer. Amongst the various signaling pathways within cancer cells that can incite the expression of inflammatory molecules are those that activate IL-1 receptor associated kinases ...
Ajay eJain +2 more
doaj +1 more source
Brazilian Journal of Poultry Science, 2022 The aim of this study is to determine the serum amino acid profile using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS / MS) in healthy male and female geese of the same age that were raised in similar care and feeding conditions.
E Yavuz +5 more
doaj +1 more source
Marine Drugs, 2017 The cationic antimicrobial peptide epinecidin-1 was identified from Epinephelus coioides and possesses multiple biological functions, including antibacterial, antifungal, anti-tumor, and immunomodulatory effects.
Bor-Chyuan Su, Jyh-Yih Chen
doaj +1 more source
PMN membranes disassociate IRAK-M from CD80.
, 2013 Macrophages were treated with PMN lipid rafts for various times Panel A. Co-IP demonstrates CD80 binds IRAK-M in resting PMA differentiated THP-1 macrophages, lane 1. One hour after lipid raft treatment IRAK-M disassociates from CD80, lane 2.
Hiroshi Kobayashi (23858) +9 more
core +1 more source
Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light
Advanced Science, EarlyView.Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley +1 more source
Advanced Science, EarlyView.Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He +9 more
wiley +1 more source
Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases
, 2007 Objective. Inflammatory bowel diseases (IBD) have a complex genetic background. The interleukin receptor associated kinase-M (IRAK-M) is a NF-kappa B-mediated, negative regulator of Toll-like receptor (TLR) signaling.
van Dullemen, Hendrik M. +10 more
core +1 more source
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
Frontiers in Immunology, 2021 Macrophages play an important role in the initiation, progression and resolution of inflammation in many human diseases. Effective regulation of their activation and immune responses could be a promising therapeutic strategy to manage various ...
Liya Sun +6 more
doaj +1 more source