Results 41 to 50 of about 22,781,794 (242)
IRAK‐M mediates Toll‐like receptor/IL‐1R‐induced NFκB activation and cytokine production [PDF]
EMBO Journal, 2013 Katarzyna Bulek, Hao Zhou, Peng Yao
exaly +2 more sources
Innate Immunity, 2021 TLRs recognizing PAMPS play a role in local immunity and participate in implant-associated loosening. TLR-mediated signaling is primarily regulated by IL-1 receptor associated kinase-M (IRAK-M) negatively and IRAK-4 positively.
Yang-chun Zhang +3 more
doaj +1 more source
Structural anomalies in a published NMR-derived structure of IRAK-M
Journal of Molecular Graphics and Modelling, 2022 Signaling by Toll-Like Receptors and the Interleukin-1 Receptor (IL1-R) involves intracellular binding of MyD88, followed by assembly of IL1-R Associated Kinases (IRAKs) into the so-called Myddosome. Using NMR, Nechama et al. determined the structure of the IRAK-M death domain monomer (PDBid: 5UKE).
Hessel Poelman +7 more
openaire +4 more sources
Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases
Reviews in Cardiovascular Medicine, 2022 Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen ...
Youjing Zheng, Jia-Qiang He
doaj +1 more source
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M [PDF]
Journal of Clinical Investigation, 2006 Sepsis results in a state of relative immunosuppression, rendering critically ill patients susceptible to secondary infections and increased mortality. Monocytes isolated from septic patients and experimental animals display a "deactivated" phenotype, characterized by impaired inflammatory and antimicrobial responses, including hyporesponsiveness to ...
Jane C, Deng +6 more
openaire +2 more sources
Additional file 3 of IRAK-M has effects in regulation of lung epithelial inflammation
, 2023 Additional file 3: Figure S2. IRAK-M expression was attenuated by IRAK-M siRNA in BEAS-2B and A549 cells. (a) Expression of IRAK-M at both mRNA level and protein level in BEAS-2B cells after IRAK-M knockdown by siRNAs.
Yi Liu (36759) +5 more
core +1 more source
Heliyon, 2022 The IL-23/IL-17 axis plays an important role in the development of autoimmune diseases, but the mechanism regulating IL-23 production is mainly unknown.
Rui Yamaguchi +6 more
doaj +1 more source
Microorganisms, 2021 Staphylococcus aureus inhibits complement activity by secreting a variety of toxins. However, the underlying mechanism of complement component regulation by lipoteichoic acid (LTA), a cell wall component of S. aureus, has not been elucidated.
Bong Jun Jung +4 more
doaj +1 more source
Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression [PDF]
The Journal of Immunology, 2009 Abstract High levels of plasma adiponectin are associated with low levels of inflammatory markers and cardioprotection. The mechanism via which adiponectin exerts its anti-inflammatory effect is yet unknown. In the present study, we demonstrate that globular adiponectin (gAd) induces the expression of the inactive isoform of IL-1R ...
Vassiliki, Zacharioudaki +5 more
openaire +2 more sources
Frontiers in Medicine, 2021 Programs to prevent mother-to-child HIV transmission do not reduce the number of infants exposed during pregnancy and breastfeeding. HIV-exposed but uninfected children (HEU) present higher risk of morbidity and mortality than HIV-unexposed and ...
Marina Rubio-Garrido +8 more
doaj +1 more source