Results 41 to 50 of about 7,342 (224)

Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M [PDF]

Journal of Clinical Investigation, 2006
Sepsis results in a state of relative immunosuppression, rendering critically ill patients susceptible to secondary infections and increased mortality. Monocytes isolated from septic patients and experimental animals display a "deactivated" phenotype, characterized by impaired inflammatory and antimicrobial responses, including hyporesponsiveness to ...
Jane C, Deng, Genhong, Cheng, Michael W, Newstead, Xianying, Zeng, Koichi, Kobayashi, Richard A, Flavell, Theodore J, Standiford   +6 more
openaire   +2 more sources

Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression [PDF]

The Journal of Immunology, 2009
Abstract High levels of plasma adiponectin are associated with low levels of inflammatory markers and cardioprotection. The mechanism via which adiponectin exerts its anti-inflammatory effect is yet unknown. In the present study, we demonstrate that globular adiponectin (gAd) induces the expression of the inactive isoform of IL-1R ...
Vassiliki, Zacharioudaki, Ariadne, Androulidaki, Alicia, Arranz, George, Vrentzos, Andrew N, Margioris, Christos, Tsatsanis   +5 more
openaire   +2 more sources

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. [PDF]

J Immunol, 2015
Abstract Idiopathic pulmonary fibrosis is a devastating lung disease characterized by inflammation and the development of excessive extracellular matrix deposition. Currently, there are only limited therapeutic intervenes to offer patients diagnosed with pulmonary fibrosis.
Ballinger MN, Newstead MW, Zeng X, Bhan U, Mo XM, Kunkel SL, Moore BB, Flavell R, Christman JW, Standiford TJ.   +9 more
europepmc   +4 more sources

IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity. [PDF]

J Immunol, 2010
Abstract To function optimally as vaccines, dendritic cells (DCs) must actively migrate to lymphoid organs and maintain a viable, mature state for sufficient time to effectively present their Ag to cognate T cells. Unfortunately, mature DCs rapidly lose viability and function after injection, and only a minority leaves the vaccine site ...
Turnis ME, Song XT, Bear A, Foster AE, Gottschalk S, Brenner MK, Chen SY, Rooney CM.   +7 more
europepmc   +4 more sources

IL-1 Receptor-associated kinase signaling and its role in inflammation, cancer progression and therapy resistance

Frontiers in Immunology, 2014
Chronic inflammation has long been associated with the development of cancer. Amongst the various signaling pathways within cancer cells that can incite the expression of inflammatory molecules are those that activate IL-1 receptor associated kinases ...
Ajay eJain, Sabina eKaczanowska, Eduardo eDavila   +2 more
doaj   +1 more source

Determination of the Relationship of Serum Amino Acid Profile with Sex and Body Weight in Healthy Geese by Liquid Chromatography-Tandem Mass Spectrometry

Brazilian Journal of Poultry Science, 2022
The aim of this study is to determine the serum amino acid profile using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS / MS) in healthy male and female geese of the same age that were raised in similar care and feeding conditions.
E Yavuz, K Irak, ÖY Çelik, M Bolacali, Y Ergiden, S Gürgöze   +5 more
doaj   +1 more source

Antimicrobial Peptide Epinecidin-1 Modulates MyD88 Protein Levels via the Proteasome Degradation Pathway

Marine Drugs, 2017
The cationic antimicrobial peptide epinecidin-1 was identified from Epinephelus coioides and possesses multiple biological functions, including antibacterial, antifungal, anti-tumor, and immunomodulatory effects.
Bor-Chyuan Su, Jyh-Yih Chen
doaj   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

The Modulatory Activity of Tryptophan Displaying Nanodevices on Macrophage Activation for Preventing Acute Lung Injury

Frontiers in Immunology, 2021
Macrophages play an important role in the initiation, progression and resolution of inflammation in many human diseases. Effective regulation of their activation and immune responses could be a promising therapeutic strategy to manage various ...
Liya Sun, Rui Wang, Chenchen Wu, Jiameng Gong, Huiqiang Ma, Shan-Yu Fung, Hong Yang   +6 more
doaj   +1 more source