Results 21 to 30 of about 7,342 (224)
IRAK-M Regulates Monocyte Trafficking to the Lungs in Response to Bleomycin Challenge. [PDF]
J Immunol, 2020 Abstract Idiopathic pulmonary fibrosis is a deadly disease characterized by excessive extracellular matrix deposition in the lungs, resulting in decreased pulmonary function. Although epithelial cells and fibroblasts have long been the focus of idiopathic pulmonary fibrosis research, the role of various subpopulations of macrophages ...
Reader BF +8 more
europepmc +4 more sources
The structure function of the death domain of human IRAK-M. [PDF]
Cell Commun Signal, 2014 IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocytes/macrophages and lung epithelial cells. Lack of IRAK-M in mice greatly improves the resistance to nosocomial pneumonia and lung tumors, which ...
Du J +5 more
europepmc +4 more sources
IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis. [PDF]
BMC Microbiol, 2017 Intracellular bacterium, Mycobacterium tuberculosis (M. tb), infects specifically macrophages as host cells. IRAK-M, a member of IRAK family, is a negative regulator in TLR signaling and specifically expresses in monocytes and macrophages. The role of IRAK-M in intracellular growth of M.
Shen P +8 more
europepmc +3 more sources
Critical Role of IRAK-M in Regulating Antigen-Induced Airway Inflammation. [PDF]
Am J Respir Cell Mol Biol, 2017 Abstract Asthma is an airway epithelium disorder involving allergic lung inflammation. IL-1 receptor–associated kinase M (IRAK-M) is a negative regulator of Toll-like receptor (TLR) signaling on airway epithelial cells and macrophages, and it is known to limit the overproduction of cytokines during the inflammatory process.
Zhang M, Chen W, Zhou W, Bai Y, Gao J.
europepmc +4 more sources
Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. [PDF]
Nat Commun, 2015 AbstractGlucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood.
Miyata M +8 more
europepmc +4 more sources
Interleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNA. [PDF]
PLoS ONE, 2012 As a part of the negative feedback mechanism, CpG DNA induces IRAK-M expression in monocytic cells. In the present study we investigated a biochemical signaling pathway and the transcription factors responsible for CpG DNA-mediated Irak-m gene expression.
Young-In Kim +4 more
doaj +1 more source
Involvement of IRAK-M in Peptidoglycan-induced Tolerance in Macrophages [PDF]
Journal of Biological Chemistry, 2004 The molecular mechanisms by which pathogen-associated molecular patterns recognized by TLR2, such as peptidoglycan (PGN), induce homotolerance are largely unknown. It was recently reported that IRAK-M negatively regulates TLR signaling. In this study, we elucidate the molecular mechanisms of tolerance induced by PGN, with a focus on the role of IRAK-M.
Kuniko, Nakayama +9 more
openaire +2 more sources
Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages [PDF]
The Journal of Immunology, 2017 Abstract During macrophage activation, expression of IL-1R–associated kinase (IRAK)-M is induced to suppress TLR-mediated responses and is a hallmark of endotoxin tolerance. Endotoxin tolerance requires tight regulation of genes occurring at the transcriptional and epigenetic levels.
Konstantina Lyroni +9 more
openaire +2 more sources
Innate Immunity, 2021 TLRs recognizing PAMPS play a role in local immunity and participate in implant-associated loosening. TLR-mediated signaling is primarily regulated by IL-1 receptor associated kinase-M (IRAK-M) negatively and IRAK-4 positively.
Yang-chun Zhang +3 more
doaj +1 more source
IRAK-M Is Involved in the Pathogenesis of Early-Onset Persistent Asthma [PDF]
The American Journal of Human Genetics, 2007 Asthma is a multifactorial disease influenced by genetic and environmental factors. In the past decade, several loci and >100 genes have been found to be associated with the disease in at least one population. Among these loci, region 12q13-24 has been implicated in asthma etiology in multiple populations, suggesting that it harbors one or more asthma ...
Lenuta Balaci +41 more
openaire +4 more sources