Results 21 to 30 of about 22,781,794 (242)

IRAK-M Knockout Exacerbates Inflammation in Mice Infected with Streptococcus equi subsp. zooepidemicus: Observation in the Jejunum [PDF]

Microorganisms
Streptococcus equi subsp. zooepidemicus (SEZ) causes severe infections, but the role of the negative regulator interleukin-1 receptor-associated kinase M (IRAK-M) in SEZ-induced inflammation is unclear.
Yuxin Che, Yi Xie, Xinyi Qiu, Junxi Lin, Yixin Xiu, Taoyu Yu, Xiaoshu Zhan, Jiedan Liao, Yunfei Huang, Yaqiong Ye, Ziteng Deng   +10 more
doaj   +2 more sources

IRAK-M Is Involved in the Pathogenesis of Early-Onset Persistent Asthma [PDF]

The American Journal of Human Genetics, 2007
Asthma is a multifactorial disease influenced by genetic and environmental factors. In the past decade, several loci and >100 genes have been found to be associated with the disease in at least one population. Among these loci, region 12q13-24 has been implicated in asthma etiology in multiple populations, suggesting that it harbors one or more asthma ...
Lenuta Balaci, Maria Cristina Spada, Nazario Olla, Gabriella Sole, Laura Loddo, Francesca Anedda, Silvia Naitza, Maria Antonietta Zuncheddu, Andrea Maschio, Daniele Altea, Manuela Uda, Sabrina Pilia, Serena Sanna, Marco Masala, Laura Crisponi, Matilde Fattori, Marcella Devoto, Silvia Doratiotto, Stefania Rassu, Simonetta Mereu, Enrico Giua, Natalina Graziella Cadeddu, Roberto Atzeni, Umberto Pelosi, Adriano Corrias, Roberto Perra, Pier Luigi Torrazza, Pietro Pirina, Francesco Ginesu, Silvano Marcias, Maria Grazia Schintu, Gennaro Sergio Del Giacco, Paolo Emilio Manconi, Giovanni Malerba, Andrea Bisognin, Elisabetta Trabetti, Attilio Boner, Lydia Pescollderungg, Pier Franco Pignatti, David Schlessinger, Antonio Cao, Giuseppe Pilia   +41 more
openaire   +5 more sources

The Role of Interleukin-1 Receptor-Associated Kinase M in Pulmonary Diseases: Mechanisms and Therapeutic Implications [PDF]

Journal of Innate Immunity
Background: Respiratory system diseases, including infections, inflammation, fibrosis, cancer, and others, impose a substantial burden on human health worldwide.
Liying Zhai, Chunhua Du, Qian Zhao, Wencheng Yu, Haihong Gong   +4 more
doaj   +2 more sources

Critical Role of IRAK-M in Regulating Antigen-Induced Airway Inflammation. [PDF]

Am J Respir Cell Mol Biol, 2017
Abstract Asthma is an airway epithelium disorder involving allergic lung inflammation. IL-1 receptor–associated kinase M (IRAK-M) is a negative regulator of Toll-like receptor (TLR) signaling on airway epithelial cells and macrophages, and it is known to limit the overproduction of cytokines during the inflammatory process.
Zhang M, Chen W, Zhou W, Bai Y, Gao J.
europepmc   +4 more sources

IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis. [PDF]

BMC Microbiol, 2017
Intracellular bacterium, Mycobacterium tuberculosis (M. tb), infects specifically macrophages as host cells. IRAK-M, a member of IRAK family, is a negative regulator in TLR signaling and specifically expresses in monocytes and macrophages. The role of IRAK-M in intracellular growth of M.
Shen P, Li Q, Ma J, Tian M, Hong F, Zhai X, Li J, Huang H, Shi C.   +8 more
europepmc   +3 more sources

Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. [PDF]

Nat Commun, 2015
AbstractGlucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood.
Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD.   +8 more
europepmc   +4 more sources

A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages. [PDF]

PLoS ONE, 2014
Nicotine stimulation of α7 nicotinic acetylcholine receptor (α7 nAChR) powerfully inhibits pro-inflammatory cytokine production in lipopolysaccharide (LPS)-stimulated macrophages and in experimental models of endotoxemia.
Maria C Maldifassi, Gema Atienza, Francisco Arnalich, Eduardo López-Collazo, Jose L Cedillo, Carolina Martín-Sánchez, Anna Bordas, Jaime Renart, Carmen Montiel   +8 more
doaj   +2 more sources

Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip. [PDF]

PLoS ONE, 2019
Macrophages (Mϕs) play a central role in mucosal immunity by pathogen sensing and instruction of adaptive immune responses. Prior challenge to endotoxin can render Mφs refractory to secondary exposure, suppressing the inflammatory response.
Khalid Al-Shaghdali, Barbara Durante, Christopher Hayward, Jane Beal, Andrew Foey   +4 more
doaj   +2 more sources

Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes. [PDF]

PLoS ONE, 2015
Immune suppression during critical illness predisposes to serious infections. We sought to determine the mechanisms regulating tolerance and cross-tolerance to common pro-inflammatory danger signals in a model that recapitulates the intact in vivo immune
Mark W Julian, Heather R Strange, Megan N Ballinger, Richard S Hotchkiss, Tracey L Papenfuss, Elliott D Crouser   +5 more
doaj   +2 more sources

Induction of IRAK-M Is Associated with Lipopolysaccharide Tolerance in a Human Endotoxemia Model [PDF]

The Journal of Immunology, 2007
Abstract Recent in vitro and murine in vivo studies have identified several potential LPS tolerance factors. In this study, we describe the expression kinetics of these LPS tolerance factors in standardized human endotoxemia models using i.v. LPS bolus administration.
van 't Veer, Cornelis, van den Pangaart, Petra S., van Zoelen, Marieke A. D., de Kruif, Martijn, Birjmohun, Rakesh S., Stroes, Eric S., de Vos, Alex F., van der Poll, Tom   +7 more
openaire   +3 more sources