The structure function of the death domain of human IRAK-M. [PDF]
Cell Commun Signal, 2014 IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocytes/macrophages and lung epithelial cells. Lack of IRAK-M in mice greatly improves the resistance to nosocomial pneumonia and lung tumors, which ...
Du J +5 more
europepmc +7 more sources
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling [PDF]
Cell, 2002 Toll-like receptors (TLRs) detect microorganisms and protect multicellular organisms from infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase IRAK. The IRAK family consists of two active kinases, IRAK and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M.
Jorge E. Galán +2 more
exaly +5 more sources
IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori. [PDF]
PLoS ONE, 2013 Helicobacter pylori (H. pylori) infects the gastric mucosa and persists for the life of the host. Bacterial persistence may be due to the induction of regulatory T cells (Tregs) whichmay have protective effects against other diseases such as asthma.
Jessica Shiu +4 more
doaj +4 more sources
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation [PDF]
Nature Communications, 2018 Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines ...
Morris Nechama +15 more
doaj +4 more sources
IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice. [PDF]
Diabetes, 2014 Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by progressive destruction of insulin-secreting pancreatic β-cells. Both T-cell–mediated adaptive responses as well as innate immune processes are involved in pathogenesis.
Tan Q +6 more
europepmc +7 more sources
IRAK-M removal counteracts dendritic cell vaccine deficits in migration and longevity. [PDF]
J Immunol, 2010 Abstract To function optimally as vaccines, dendritic cells (DCs) must actively migrate to lymphoid organs and maintain a viable, mature state for sufficient time to effectively present their Ag to cognate T cells. Unfortunately, mature DCs rapidly lose viability and function after injection, and only a minority leaves the vaccine site ...
Turnis ME +7 more
europepmc +5 more sources
IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis [PDF]
Cell Death and Disease, 2023 The activation of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome triggers pyroptosis proinflammatory cell death in experimental autoimmune encephalomyelitis (EAE).
Yuanyuan Wang +9 more
doaj +2 more sources
Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study [PDF]
Journal of International Medical Research, 2022 Objective To investigate whether IL-1R-associated kinase (IRAK)-M is associated with prediabetes and type 2 diabetes (T2D). Methods In this cross-sectional study, enrolled subjects were assigned to different groups according to their fasting plasma ...
Xiaomin Xie +5 more
doaj +2 more sources
SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages [PDF]
Frontiers in Immunology, 2021 The major cause of death in SARS-CoV-2 infected patients is due to de-regulation of the innate immune system and development of cytokine storm. SARS-CoV-2 infects multiple cell types in the lung, including macrophages, by engagement of its spike (S ...
Ioanna Pantazi +11 more
doaj +2 more sources
IRAK-M Regulates Monocyte Trafficking to the Lungs in Response to Bleomycin Challenge. [PDF]
J Immunol, 2020 Abstract Idiopathic pulmonary fibrosis is a deadly disease characterized by excessive extracellular matrix deposition in the lungs, resulting in decreased pulmonary function. Although epithelial cells and fibroblasts have long been the focus of idiopathic pulmonary fibrosis research, the role of various subpopulations of macrophages ...
Reader BF +8 more
europepmc +4 more sources