IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori. [PDF]
PLoS ONE, 2013 Helicobacter pylori (H. pylori) infects the gastric mucosa and persists for the life of the host. Bacterial persistence may be due to the induction of regulatory T cells (Tregs) whichmay have protective effects against other diseases such as asthma.
Jessica Shiu +4 more
doaj +2 more sources
A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages. [PDF]
PLoS ONE, 2014 Nicotine stimulation of α7 nicotinic acetylcholine receptor (α7 nAChR) powerfully inhibits pro-inflammatory cytokine production in lipopolysaccharide (LPS)-stimulated macrophages and in experimental models of endotoxemia.
Maria C Maldifassi +8 more
doaj +2 more sources
IRAK-M regulation and function in host defense and immune homeostasis [PDF]
Infectious Disease Reports, 2010 Antigen presenting cells (APCs) of the innate immune system sense a wide range of pathogens via pattern recognition receptors (PRRs). Engagement of certain PRRs can induce production of pro-inflammatory mediators that facilitate effective clearance of ...
Leah L.N. Hubbard, Bethany B. Moore
doaj +2 more sources
Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip. [PDF]
PLoS ONE, 2019 Macrophages (Mϕs) play a central role in mucosal immunity by pathogen sensing and instruction of adaptive immune responses. Prior challenge to endotoxin can render Mφs refractory to secondary exposure, suppressing the inflammatory response.
Khalid Al-Shaghdali +4 more
doaj +2 more sources
The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes. [PDF]
PLoS ONE, 2015 Alpha-melanocyte stimulating hormone (α-MSH) is a highly conserved 13-aa neuropeptide derived from pro-opiomelanocortin by post-translational processing, which has been reported to exhibit potent anti-inflammatory activity and a wide range of ...
Sunhyo Ryu +6 more
doaj +2 more sources
Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes. [PDF]
PLoS ONE, 2015 Immune suppression during critical illness predisposes to serious infections. We sought to determine the mechanisms regulating tolerance and cross-tolerance to common pro-inflammatory danger signals in a model that recapitulates the intact in vivo immune
Mark W Julian +5 more
doaj +2 more sources
IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis. [PDF]
PLoS ONE, 2010 Sepsis results in a profound state of immunosuppression, which is temporally associated with impaired leukocyte function. The mechanism of leukocyte reprogramming in sepsis is incompletely understood. In this study, we explored mechanisms contributing to
Kenneth Lyn-Kew +7 more
doaj +2 more sources
Author Correction: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation [PDF]
Nature Communications, 2023 Morris Nechama +15 more
doaj +2 more sources
Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses [PDF]
Molecular Therapy, 2020 Yao Zhang, Na Diao, Hong Wei Chu
exaly +2 more sources
Correction: Role of IRAK-M in Alcohol Induced Liver Injury
PLoS ONE, 2014 Yipeng Wang +8 more
doaj +4 more sources