The role of interleukin-1 receptor-associated kinases in Vogt-Koyanagi-Harada disease. [PDF]
PLoS ONE, 2014 PurposeTo explore whether IRAK1 and IRAK4 are involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.MethodsThirty-nine VKH patients and thirty-two healthy controls were included in this study.
Min Sun +4 more
doaj +4 more sources
Multi-locus SNP analyses of interleukin 1 receptor associated kinases 2 gene polymorphisms with the susceptibility to rheumatoid arthritis. [PDF]
PLoS ONE, 2022 BackgroundThe genetic polymorphisms (rs708035, rs3844283) of Interleukin-1 receptor associated kinases 2 (IRAK2) is involved in the NFκB regulatory pathway. The frequencies of IRAK2 gene are unknown in Pakistani population.
Maham Ghouri +6 more
doaj +2 more sources
Phosphoregulation of interleukin-1 receptor-associated kinase 1 in inflammatory signaling [PDF]
Frontiers in ImmunologyInterleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine kinase that functions as a central transducer of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, linking pathogen recognition to the activation of nuclear ...
Manasa Suresh +5 more
doaj +2 more sources
A highly selective inhibitor of interleukin-1 receptor–associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase [PDF]
Journal of Biological Chemistry, 2020 Timothy Haystead +2 more
exaly +2 more sources
Pharmaceutical Fronts, 2020 Interleukin-1 receptor antagonist is an important acute-phase protein and an immune mediator, and its expression is associated with the development of hepatitis or acute liver failure.
Ying Zheng +7 more
doaj +1 more source
Effect of IRAK1/4 inhibitor on IL-1β, IL-6, INF-γ and TNF-α expression in breast cancer cells of several lines [PDF]
The Ukrainian Biochemical Journal, 2021 Recent studies have shown that inflammation mediated via interleukin-1 receptor-associated kinases (IRAKs) is associated with cancer cells drug resistance.
M. Rezaei +4 more
doaj +1 more source
Interleukin-1 Receptor-Associated Kinase 4 Deficiency in a Greek Teenager [PDF]
Case Reports in Immunology, 2020 Background. Human interleukin- (IL-) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently described primary immunodeficiency. It is a rare, autosomal recessive immunodeficiency that impairs toll/IL-1R immunity, except for the toll-like receptor (TLR) 3- and TLR4-interferon alpha (IFNA)/beta (IFNB) pathways. Case Report.
Panagiota Karananou +2 more
openaire +4 more sources
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages
Frontiers in Immunology, 2021 Mitofusin 2 (MFN2) is a mitochondrial outer membrane GTPase, which modulates mitochondrial fusion and affects the interaction between endoplasmic reticulum and mitochondria.
Vera Khodzhaeva +9 more
doaj +1 more source
Scientific Reports, 2023 TAS-115 is an oral multi-receptor tyrosine kinase inhibitor that strongly inhibits kinases implicated in antitumor immunity, such as colony stimulating factor 1 receptor and vascular endothelial growth factor receptor.
Toshihiro Shibutani +10 more
doaj +1 more source
Experimental and Molecular Medicine, 2023 Senescence, a hallmark of aging, is a factor in age-related diseases (ARDs). Therefore, targeting senescence is widely regarded as a practicable method for modulating the effects of aging and ARDs.
Jung-Jin Park +8 more
doaj +1 more source