Results 11 to 20 of about 36,414,078 (299)
Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy [PDF]
Oncotarget, 2018 Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and IRAK4) are serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling pathways, through which they regulate innate immunity and inflammation. Evidence exists that IRAKs play key roles in the pathophysiologies of cancers, and metabolic and inflammatory ...
Singer, Jack W +5 more
openaire +6 more sources
Plant and Animal Pathogen Recognition Receptors Signal through Non-RD Kinases.
PLoS Pathogens, 2006 Plants and animals mediate early steps of the innate immune response through pathogen recognition receptors (PRRs). PRRs commonly associate with or contain members of a monophyletic group of kinases called the interleukin-1 receptor-associated kinase ...
Christopher Dardick, Pamela Ronald
doaj +2 more sources
Computer aided designing of novel pyrrolopyridine derivatives as JAK1 inhibitors
Scientific Reports, 2021 Janus kinases (JAKs) are a family of non-receptor kinases that play a key role in cytokine signaling and their aberrant activities are associated with the pathogenesis of various immune diseases.
Seketoulie Keretsu +2 more
doaj +1 more source
Structure of the IL-27 quaternary receptor signaling complex
eLife, 2022 Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-mediated inflammation and plays an important role in immune homeostasis.
Nathanael A Caveney +4 more
doaj +1 more source
Neural Regeneration Research, 2022 Complement component (3b/4b) receptor 1 (CR1) expression is positively related to the abundance of phosphorylated microtubule-associated protein tau (tau), and CR1 expression is associated with susceptibility to Alzheimer’s disease.
Xi-Chen Zhu +3 more
doaj +1 more source
Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages [PDF]
, 2002 During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products.
Sweet, Matthew J +15 more
core +1 more source
Clinical and Translational Medicine, 2022 Background Nonalcoholic fatty liver disease (NAFLD) is associated with hepatic as well as systemic insulin resistance even in the absence of type 2 diabetes.
Nadine Gehrke +6 more
doaj +1 more source
Activation of Interleukin-1 Receptor-Associated Kinase by Gram-Negative Flagellin [PDF]
Infection and Immunity, 2001 ABSTRACTFlagellin from various species of gram-negative bacteria activates monocytes to produce proinflammatory cytokines. We have analyzed the pathway by whichSalmonella enteritidisflagellin (FliC) activates murine and human monocyte/macrophage-like cell lines. Since lipopolysaccharide (LPS), the principal immune stimulatory component of gram-negative
M A, Moors, L, Li, S B, Mizel
openaire +2 more sources
Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]
, 2008 Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
core +1 more source
Cells, 2020 In this study, we investigated the functional role of isoprenylcysteine carboxyl methyltransferase (ICMT) and its methylatable substrate Ras in Toll-like receptor (TLR)-activated macrophages and in mouse inflammatory disease conditions.
Woo Seok Yang +12 more
doaj +1 more source