Results 31 to 40 of about 36,414,078 (299)

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies [PDF]

open access: yes, 2012
BACKGROUND: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades.
Thomas, GN   +492 more
core   +1 more source

Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]

open access: yes, 2001
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Hoelzer, Dieter (Prof. Dr.)   +7 more
core   +1 more source

Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]

open access: yesAdv Sci (Weinh)
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc   +2 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

open access: yes, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett   +24 more
core   +1 more source

JNK and ERK8 as downstream effectors of receptor tyrosine kinases [PDF]

open access: yes, 2006
MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core   +1 more source

Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β−NF-κB/IRF3 and JAK2/TYK2−STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization

open access: yesCells, 2022
M2-polarization and the tumoricidal to tumor-promoting transition are commonly observed with tumor-infiltrating macrophages after interplay with cancer cells or/and other stroma cells.
Chi-Shuan Fan   +6 more
doaj   +1 more source

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia [PDF]

open access: yes, 2012
<b>Objective—</b><p></p> The p75 neurotrophin receptor (p75<sup>NTR</sup>) contributes to diabetes mellitus−induced defective postischemic neovascularization.
Spinetti, Gaia   +34 more
core   +1 more source

The Interleukin-1 Receptor-associated Kinase Is Degraded by Proteasomes following Its Phosphorylation [PDF]

open access: yesJournal of Biological Chemistry, 1997
Following interleukin (IL)-1 stimulation, the majority of the cellular interleukin-1 receptor-associated kinase (IRAK) translocates to a discrete subset of the Type I IL-1 receptor (IL-1R1) in MRC-5 human lung fibroblasts. As the IRAK becomes multiphosphorylated, it is degraded by proteasomes at a rate comparable to that of the degradation of the ...
T T, Yamin, D K, Miller
openaire   +2 more sources

Cholesterol Oxidase Binds TLR2 and Modulates Functional Responses of Human Macrophages

open access: yesMediators of Inflammation, 2014
Cholesterol oxidase (ChoD) is considered to be an important virulence factor for Mycobacterium tuberculosis (Mtb), but its influence on macrophage activity is unknown. Here we used Nocardia erythropolis ChoD, which is very similar to the Mtb enzyme (70%
Katarzyna Bednarska   +4 more
doaj   +1 more source

The Role of Interleukin-1 Receptor-Associated Kinase M in Pulmonary Diseases: Mechanisms and Therapeutic Implications

open access: yesJournal of Innate Immunity
Background: Respiratory system diseases, including infections, inflammation, fibrosis, cancer, and others, impose a substantial burden on human health worldwide.
Liying Zhai   +4 more
doaj   +1 more source

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