Results 31 to 40 of about 7,342 (224)

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling [PDF]

Cell, 2002
Toll-like receptors (TLRs) detect microorganisms and protect multicellular organisms from infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase IRAK. The IRAK family consists of two active kinases, IRAK and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M.
Kobayashi, Koichi, Hernandez, Lorraine D., Galán, Jorge E., Janeway, Charles A., Medzhitov, Ruslan, Flavell, Richard A.   +5 more
openaire   +2 more sources

Structural anomalies in a published NMR-derived structure of IRAK-M

Journal of Molecular Graphics and Modelling, 2022
Signaling by Toll-Like Receptors and the Interleukin-1 Receptor (IL1-R) involves intracellular binding of MyD88, followed by assembly of IL1-R Associated Kinases (IRAKs) into the so-called Myddosome. Using NMR, Nechama et al. determined the structure of the IRAK-M death domain monomer (PDBid: 5UKE).
Hessel Poelman, Hans Ippel, Berke Gürkan, Rolf Boelens, Gert Vriend, Cornelis van ‘t Veer, Esther Lutgens, Gerry A.F. Nicolaes   +7 more
openaire   +4 more sources

Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Reviews in Cardiovascular Medicine, 2022
Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen ...
Youjing Zheng, Jia-Qiang He
doaj   +1 more source

IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation. [PDF]

J Immunol, 2019
Abstract IL-1R–associated kinase (IRAK)-M regulates lung immunity during asthmatic airway inflammation. However, the regulatory effect of IRAK-M differs when airway inflammation persists. A positive association between IRAK-M polymorphisms with childhood asthma has been reported.
Liu Y, Zhang M, Lou L, Li L, Zhang Y, Chen W, Zhou W, Bai Y, Gao J.   +8 more
europepmc   +4 more sources

Induction of IRAK-M Is Associated with Lipopolysaccharide Tolerance in a Human Endotoxemia Model [PDF]

The Journal of Immunology, 2007
Abstract Recent in vitro and murine in vivo studies have identified several potential LPS tolerance factors. In this study, we describe the expression kinetics of these LPS tolerance factors in standardized human endotoxemia models using i.v. LPS bolus administration.
van 't Veer, Cornelis, van den Pangaart, Petra S., van Zoelen, Marieke A. D., de Kruif, Martijn, Birjmohun, Rakesh S., Stroes, Eric S., de Vos, Alex F., van der Poll, Tom   +7 more
openaire   +2 more sources

IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice. [PDF]

Diabetes, 2014
Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by progressive destruction of insulin-secreting pancreatic β-cells. Both T-cell–mediated adaptive responses as well as innate immune processes are involved in pathogenesis.
Tan Q, Majewska-Szczepanik M, Zhang X, Szczepanik M, Zhou Z, Wong FS, Wen L.   +6 more
europepmc   +5 more sources

IL-23 production in human macrophages is regulated negatively by tumor necrosis factor α-induced protein 3 and positively by specificity protein 1 after stimulation of the toll-like receptor 7/8 signaling pathway

Heliyon, 2022
The IL-23/IL-17 axis plays an important role in the development of autoimmune diseases, but the mechanism regulating IL-23 production is mainly unknown.
Rui Yamaguchi, Arisa Sakamoto, Reona Yamaguchi, Misa Haraguchi, Shinji Narahara, Hiroyuki Sugiuchi, Yasuo Yamaguch   +6 more
doaj   +1 more source

Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts. [PDF]

Arterioscler Thromb Vasc Biol, 2012
Objective— Effective postinfarction repair requires timely suppression of innate immune signals to prevent the catastrophic consequences of uncontrolled inflammation on cardiac geometry and function. In macrophages, interleukin-1 receptor-associated kinase (IRAK)-M acts as a functional decoy preventing uncontrolled toll-like ...
Chen W, Saxena A, Li N, Sun J, Gupta A, Lee DW, Tian Q, Dobaczewski M, Frangogiannis NG.   +8 more
europepmc   +4 more sources

Lipoteichoic Acid from Staphylococcus aureus Activates the Complement System via C3 Induction and CD55 Inhibition

Microorganisms, 2021
Staphylococcus aureus inhibits complement activity by secreting a variety of toxins. However, the underlying mechanism of complement component regulation by lipoteichoic acid (LTA), a cell wall component of S. aureus, has not been elucidated.
Bong Jun Jung, Hangeun Kim, Kyoung Ok Jang, Seongjae Kim, Dae Kyun Chung   +4 more
doaj   +1 more source

Dried Blood Specimens as an Alternative Specimen for Immune Response Monitoring During HIV Infection: A Proof of Concept and Simple Method in a Pediatric Cohort

Frontiers in Medicine, 2021
Programs to prevent mother-to-child HIV transmission do not reduce the number of infants exposed during pregnancy and breastfeeding. HIV-exposed but uninfected children (HEU) present higher risk of morbidity and mortality than HIV-unexposed and ...
Marina Rubio-Garrido, José Avendaño-Ortiz, José Avendaño-Ortiz, Adolphe Ndarabu, Carolina Rubio, Gabriel Reina, Eduardo López-Collazo, Eduardo López-Collazo, África Holguín   +8 more
doaj   +1 more source