Results 31 to 40 of about 22,781,794 (242)

The Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes. [PDF]

PLoS ONE, 2015
Alpha-melanocyte stimulating hormone (α-MSH) is a highly conserved 13-aa neuropeptide derived from pro-opiomelanocortin by post-translational processing, which has been reported to exhibit potent anti-inflammatory activity and a wide range of ...
Sunhyo Ryu, Andrew Johnson, Yoonkyung Park, Beomjoon Kim, David Norris, Cheryl A Armstrong, Peter I Song   +6 more
doaj   +2 more sources

IRAK-M Associates with Susceptibility to Adult-Onset Asthma and Promotes Chronic Airway Inflammation. [PDF]

J Immunol, 2019
Abstract IL-1R–associated kinase (IRAK)-M regulates lung immunity during asthmatic airway inflammation. However, the regulatory effect of IRAK-M differs when airway inflammation persists. A positive association between IRAK-M polymorphisms with childhood asthma has been reported.
Liu Y, Zhang M, Lou L, Li L, Zhang Y, Chen W, Zhou W, Bai Y, Gao J.   +8 more
europepmc   +4 more sources

Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts. [PDF]

Arterioscler Thromb Vasc Biol, 2012
Objective— Effective postinfarction repair requires timely suppression of innate immune signals to prevent the catastrophic consequences of uncontrolled inflammation on cardiac geometry and function. In macrophages, interleukin-1 receptor-associated kinase (IRAK)-M acts as a functional decoy preventing uncontrolled toll-like ...
Chen W, Saxena A, Li N, Sun J, Gupta A, Lee DW, Tian Q, Dobaczewski M, Frangogiannis NG.   +8 more
europepmc   +4 more sources

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. [PDF]

J Immunol, 2015
Abstract Idiopathic pulmonary fibrosis is a devastating lung disease characterized by inflammation and the development of excessive extracellular matrix deposition. Currently, there are only limited therapeutic intervenes to offer patients diagnosed with pulmonary fibrosis.
Ballinger MN, Newstead MW, Zeng X, Bhan U, Mo XM, Kunkel SL, Moore BB, Flavell R, Christman JW, Standiford TJ.   +9 more
europepmc   +4 more sources

Author Correction: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation [PDF]

Nature Communications, 2023
Morris Nechama, Jeahoo Kwon, Shuo Wei, Adrian Tun-Kyi, Robert S. Welner, Iddo Z. Ben-Dov, Mohamed S. Arredouani, John M. Asara, Chun-Hau Chen, Cheng-Yu Tsai, Kyle F. Nelson, Koichi S. Kobayashi, Elliot Israel, Xiao Zhen Zhou, Linda K. Nicholson, Kun Ping Lu   +15 more
doaj   +2 more sources

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration [PDF]

Science Translational Medicine
Chronic inflammation is a constitutive component of many age-related diseases, including age-related macular degeneration (AMD). Here, we identified interleukin-1 receptor–associated kinase M (IRAK-M) as a key immunoregulator in retinal pigment epithelium (RPE) that declines during the aging process. Rare genetic variants ofIRAK3, which encodes IRAK-M,
Jian Liu, David A. Copland, Alison J. Clare, Mathias Gorski, Burt T. Richards, Louis Scott, Sofia Theodoropoulou, Ursula Greferath, Katherine Cox, Gongyu Shi, Oliver H. Bell, Kepeng Ou, Jenna Le Brun Powell, Jiahui Wu, Luis Martinez Robles, Yingxin Li, Lindsay B. Nicholson, Peter J. Coffey, Erica L. Fletcher, Robyn Guymer, Monte J. Radeke, Iris M. Heid, Gregory S. Hageman, Ying Kai Chan, Andrew D. Dick   +24 more
core   +7 more sources

Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration [PDF]

, 2023
Unchecked, chronic inflammation is a constitutive component of age-related diseases, including age-related macular degeneration (AMD). Here we identified interleukin-1 receptor-associated kinase (IRAK)-M as a key immunoregulator in retinal pigment ...
Li, Yingxin, Dick, Andrew D, Nicholson, Lindsay B, Cox, Katherine, Bell, Oliver H, Ou, Kepeng, Greferath, Ursula, Coffey, Peter J, Theodoropoulou, Sofia, Fletcher, Erica L, Chan, Ying Kai, Hageman, Gregory S, Clare, Alison J, Richards, Burt T, Radeke, Monte J, Scott, Louis, Liu, Jian, Copland, David A, Guymer, Robyn, Robles, Luis Martinez, Powell, Jenna Le Brun, Gorski, Mathias, Heid, Iris M, Wu, Jiahui   +23 more
core   +3 more sources

Interleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNA. [PDF]

PLoS ONE, 2012
As a part of the negative feedback mechanism, CpG DNA induces IRAK-M expression in monocytic cells. In the present study we investigated a biochemical signaling pathway and the transcription factors responsible for CpG DNA-mediated Irak-m gene expression.
Young-In Kim, Jeoung-Eun Park, Ki Han Kwon, Cheol Yi Hong, Ae-Kyung Yi   +4 more
doaj   +1 more source

Involvement of IRAK-M in Peptidoglycan-induced Tolerance in Macrophages [PDF]

Journal of Biological Chemistry, 2004
The molecular mechanisms by which pathogen-associated molecular patterns recognized by TLR2, such as peptidoglycan (PGN), induce homotolerance are largely unknown. It was recently reported that IRAK-M negatively regulates TLR signaling. In this study, we elucidate the molecular mechanisms of tolerance induced by PGN, with a focus on the role of IRAK-M.
Kuniko, Nakayama, Shu, Okugawa, Shintaro, Yanagimoto, Takatoshi, Kitazawa, Kunihisa, Tsukada, Miki, Kawada, Satoshi, Kimura, Koichi, Hirai, Yohtaroh, Takagaki, Yasuo, Ota   +9 more
openaire   +3 more sources

Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages [PDF]

The Journal of Immunology, 2017
Abstract During macrophage activation, expression of IL-1R–associated kinase (IRAK)-M is induced to suppress TLR-mediated responses and is a hallmark of endotoxin tolerance. Endotoxin tolerance requires tight regulation of genes occurring at the transcriptional and epigenetic levels.
Konstantina Lyroni, Andreas Patsalos, Maria G Daskalaki, Christina Doxaki, Birte Soennichsen, Mike Helms, Ioannis Liapis, Vassiliki Zacharioudaki, Sotirios C Kampranis, Christos Tsatsanis   +9 more
openaire   +2 more sources