The IRAK-M death domain: a tale of three surfaces [PDF]
Frontiers in Molecular Biosciences, 2023 The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 dependent ...
Berke Gürkan +26 more
doaj +7 more sources
IRAK-M has effects in regulation of lung epithelial inflammation [PDF]
Respiratory Research, 2023 Background Epithelial barrier is important for asthma development by shaping immune responses. Airway expressing-IL-1 receptor-associated kinase (IRAK)-M of Toll-like receptor pathway was involved in immunoregulation of airway inflammation through ...
Jia Li +5 more
doaj +7 more sources
Role of IRAK-M in alcohol induced liver injury. [PDF]
PLoS ONE, 2013 Increasing evidence suggests that innate immunity plays an important role in alcohol-induced liver injury and most studies have focused on positive regulation of innate immunity.
Yipeng Wang +8 more
doaj +8 more sources
Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M [PDF]
EBioMedicine, 2017 Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation.
Richard F Helm, Daniel J Slade, Liwu Li
exaly +5 more sources
Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking [PDF]
Mediators of Inflammation, 2017 Background. IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts. We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute ...
Haihong Gong +4 more
doaj +6 more sources
IRAK-M regulation and function in host defense and immune homeostasis [PDF]
Infectious Disease Reports, 2010 Antigen presenting cells (APCs) of the innate immune system sense a wide range of pathogens via pattern recognition receptors (PRRs). Engagement of certain PRRs can induce production of pro-inflammatory mediators that facilitate effective clearance of ...
Leah L.N. Hubbard, Bethany B. Moore
doaj +7 more sources
IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice [PDF]
Frontiers in Cellular Neuroscience, 2018 Background: Innate immune response to neuronal death is one of the key events of the pathogenesis of ischemic brain injury. Interleukin-1 receptor-associated kinase (IRAK)-M, encoded by gene Irak3, negatively regulates toll-like receptor signaling by ...
Chenfei Lyu +10 more
doaj +6 more sources
Correction: Role of IRAK-M in Alcohol Induced Liver Injury
PLoS ONE, 2014 Dr. Huiping Yan is co-corresponding author with Dr. Li Wen. Dr.
Yipeng Wang +8 more
doaj +6 more sources
Neutrophils Deficient in Innate Suppressor IRAK-M Enhances Anti-tumor Immune Responses [PDF]
Molecular Therapy, 2020 Tumor-associated immune-suppressive neutrophils are prevalent in various cancers, including colorectal cancer. However, mechanisms of immune-suppressive neutrophils are not well understood. We report that a key innate suppressor, IRAK-M (interleukin-1 receptor-associated kinase M), is critically involved in the establishment of immune-suppressive ...
Liwu Li, Yao Zhang, Hong Wei Chu
exaly +5 more sources
IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis. [PDF]
PLoS ONE, 2010 Sepsis results in a profound state of immunosuppression, which is temporally associated with impaired leukocyte function. The mechanism of leukocyte reprogramming in sepsis is incompletely understood. In this study, we explored mechanisms contributing to
Kenneth Lyn-Kew +7 more
doaj +5 more sources