The IRAK-M death domain: a tale of three surfaces [PDF]
Frontiers in Molecular Biosciences, 2023 The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 dependent ...
Cornelis Van 'T Veer +2 more
exaly +4 more sources
Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M [PDF]
EBioMedicine, 2017 Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation.
Na Diao +2 more
exaly +4 more sources
IRAK-M has effects in regulation of lung epithelial inflammation [PDF]
Respiratory Research, 2023 Background Epithelial barrier is important for asthma development by shaping immune responses. Airway expressing-IL-1 receptor-associated kinase (IRAK)-M of Toll-like receptor pathway was involved in immunoregulation of airway inflammation through ...
Jia Li +5 more
doaj +2 more sources
IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis [PDF]
Cell Death and Disease, 2023 The activation of the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome triggers pyroptosis proinflammatory cell death in experimental autoimmune encephalomyelitis (EAE).
Yuanyuan Wang +9 more
doaj +2 more sources
Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study [PDF]
Journal of International Medical Research, 2022 Objective To investigate whether IL-1R-associated kinase (IRAK)-M is associated with prediabetes and type 2 diabetes (T2D). Methods In this cross-sectional study, enrolled subjects were assigned to different groups according to their fasting plasma ...
Xiaomin Xie +5 more
doaj +2 more sources
SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages [PDF]
Frontiers in Immunology, 2021 The major cause of death in SARS-CoV-2 infected patients is due to de-regulation of the innate immune system and development of cytokine storm. SARS-CoV-2 infects multiple cell types in the lung, including macrophages, by engagement of its spike (S ...
Ioanna Pantazi +11 more
doaj +2 more sources
IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice [PDF]
Frontiers in Cellular Neuroscience, 2018 Background: Innate immune response to neuronal death is one of the key events of the pathogenesis of ischemic brain injury. Interleukin-1 receptor-associated kinase (IRAK)-M, encoded by gene Irak3, negatively regulates toll-like receptor signaling by ...
Chenfei Lyu +10 more
doaj +2 more sources
Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking [PDF]
Mediators of Inflammation, 2017 Background. IRAK-M, negatively regulating Toll-like receptor, is shown the dual properties in the varied disease contexts. We studied the effect of IRAK-M deficiency on cigarette smoking- (CS-) induced airway inflammation under acute or subacute ...
Haihong Gong +4 more
doaj +2 more sources
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation [PDF]
Nature Communications, 2018 Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines ...
Morris Nechama +15 more
doaj +2 more sources
Role of IRAK-M in alcohol induced liver injury. [PDF]
PLoS ONE, 2013 Increasing evidence suggests that innate immunity plays an important role in alcohol-induced liver injury and most studies have focused on positive regulation of innate immunity.
Yipeng Wang +8 more
doaj +2 more sources