Results 11 to 20 of about 492,305 (300)
Academic Medicine, 2004 Improving medical practice begins with the improvement of medical education. In this process, most academic medical faculty assume the dual roles of both teacher and researcher, often without intending to or realizing that they are. With the increased tightening of regulation and supervision of biomedical research in the United States, academic medical
John M, Tomkowiak, Anne J, Gunderson
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Cambridge Quarterly of Healthcare Ethics, 1994 I have been a member of the Loyola University of Chicago, Medical Center Institutional Review Board (IRB) for 12 years and Chair for the last 4 years. The Medical Center Campus is a full-service academic medical center, providing tertiary and primary care to Chicago and its western suburbs.
Micetich, Kenneth Craig
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IRB Jurisdiction and Limits on IRB Actions
IRB: Ethics and Human Research, 1985 In their article in the July/August 1984 issue of IRB: A Review of Human Subjects Research, Cristina Cann and Kenneth Rothman describe practices of some IRBs in connection with epidemiologic research. The authors charge IRBs with imposing unjustified requirements or conditions (those not required by the current federal regulations).
Cann, Christina I. +3 more
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American Journal of Clinical Pathology, 2001 During the last 2 years, regulatory agencies have taken a more visible role in the enforcement of statutory regulations that exist to protect the rights of human research subjects. In 1998 the Office of the Inspector General (OIG) of the Department of Health and Human Services (DHHS) issued a series of reports addressing inadequacies in the ...
C M, Lehman, G M, Rodgers
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IRB Reform in North America: Challenges and Opportunities
McGill Journal of Medicine, 2020 Clinical research is necessary to advance medical knowledge and to test new drugs or devices. It is therefore vital to society, and ethically imperative, that clinical studies be performed if patients are to have access to safe and effective treatments ...
Marjorie Ellen Zettler
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Journal of Clinical and Translational Science, 2022 For decades, the research community called for streamlined Institutional Review Board (IRB) review processes for multisite studies. Department of Health and Human Services and National Institutes of Health (NIH) recognized this need and implemented ...
Emily Sheffer Serdoz +7 more
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Bioactivity descriptors for uncharacterized chemical compounds
Nature Communications, 2021 Chemical descriptors encode the physicochemical and structural properties of small molecules, and they are at the core of chemoinformatics. The broad release of bioactivity data has prompted enriched representations of compounds, reaching beyond chemical
Martino Bertoni +12 more
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Increasing the precision of orthology-based complex prediction through network alignment [PDF]
PeerJ, 2014 Macromolecular assemblies play an important role in almost all cellular processes. However, despite several large-scale studies, our current knowledge about protein complexes is still quite limited, thus advocating the use of in silico predictions to ...
Roland A. Pache, Patrick Aloy
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Genome Medicine, 2021 Background In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective.
Eduardo Pauls +13 more
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Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
Nature Communications, 2023 Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents.
Joan Pous +11 more
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