Results 11 to 20 of about 459,568 (307)
IRB-approved TUTT protocol version 4.0_10 March 2020_.
, 2023 IRB-approved TUTT protocol version 4.0_10 March 2020_.
Limakatso Lebina (554886) +17 more
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Genome Biology, 2022 Background Vertebrate CPEB proteins bind mRNAs at cytoplasmic polyadenylation elements (CPEs) in their 3′ UTRs, leading to cytoplasmic changes in their poly(A) tail lengths; this can promote translational repression or activation of the mRNA.
Berta Duran-Arqué +10 more
doaj +1 more source
The ATM signaling network in development and disease
Frontiers in Genetics, 2013 The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the appropriate cellular programs to maintain genome integrity. This includes the coordination of cell cycle checkpoints, transcription, translation, DNA repair, metabolism and ...
Travis H. Stracker +4 more
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Nature Communications, 2023 p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several diseases including inflammation, immune disorders and cancer,
Lorena González +18 more
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EMBO Molecular Medicine, 2013 The p38 MAPK pathway is an important regulator of many cellular responses. It is well established that p38 MAPK signalling negatively regulates epithelial cell transformation, but enhanced p38 MAPK activity has been also correlated with bad clinical ...
Lorena Pereira +4 more
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Exploring the OncoGenomic Landscape of cancer
Genome Medicine, 2018 Background The widespread incorporation of next-generation sequencing into clinical oncology has yielded an unprecedented amount of molecular data from thousands of patients.
Lidia Mateo +3 more
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Deleterious effects of neuronal accumulation of glycogen in flies and mice
EMBO Molecular Medicine, 2012 Under physiological conditions, most neurons keep glycogen synthase (GS) in an inactive form and do not show detectable levels of glycogen. Nevertheless, aberrant glycogen accumulation in neurons is a hallmark of patients suffering from Lafora disease or
Jordi Duran +5 more
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Encircling the regions of the pharmacogenomic landscape that determine drug response
Genome Medicine, 2019 Background The integration of large-scale drug sensitivity screens and genome-wide experiments is changing the field of pharmacogenomics, revealing molecular determinants of drug response without the need for previous knowledge about drug action.
Adrià Fernández-Torras +2 more
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How Do Cancer-Related Mutations Affect the Oligomerisation State of the p53 Tetramerisation Domain?
Current Issues in Molecular Biology, 2023 Tumour suppressor p53 plays a key role in the development of cancer and has therefore been widely studied in recent decades. While it is well known that p53 is biologically active as a tetramer, the tetramerisation mechanism is still not completely ...
Federica Nicolini +7 more
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RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation
EMBO Molecular Medicine, 2014 In estrogen receptor‐negative breast cancer patients, metastatic relapse usually occurs in the lung and is responsible for the fatal outcome of the disease. Thus, a better understanding of the biology of metastasis is needed. In particular, biomarkers to
Mònica Morales +12 more
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