Results 111 to 120 of about 46,447 (205)

Targeting FAR1 to inhibit intestinal macrophage ferroptosis: repurposing irinotecan as a novel sepsis therapy. [PDF]

Apoptosis
Deng H, Wang W, Li Q, Xiang X, Zhu Y, Zhang Z, Zhou X, Wu Y, Zhang J, Liu L, Li T.   +10 more
europepmc   +1 more source

Genomic Medicine Sweden: Advancing precision medicine at the national level

Journal of Internal Medicine, Volume 300, Issue 4, Page 397-419, October 2026.
Abstract High‐throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease‐causing genetic alterations and facilitating individualised treatment and care.
Anders Edsjö, Anna Lindstrand, Panagiotis Baliakas, David Gisselsson, Paula Mölling, Mia Wadelius, Åsa Johansson, Hannes Olauson, Hans Ehrencrona, Lovisa Lovmar, Christian G. Giske, Henrik Green, Ann Nordgren, Fulya Taylan, Martin Hallbeck, Erika Tång Hallbäck, Anna Green, Markus Heidenblad, Kina Höglund, Anders Jemt, Carl Mårten Lindqvist, Maria Johansson Soller, Magnus Sabel, Colum Walsh, Hartmut Vogt, Craig E. Wheelock, Martin Bergö, Jens Enoksson, Ann Ekberg Jansson, Cecilia Fagerström, Jan Holgersson, Stephanie Anja Juran, Mats G. Karlsson, Frida Lundmark, Eva Tiensuu Janson, Andreas Muranyi Scheutz, Malin Sund, Päivi Östling, Sofia Gruvberger‐Saal, Marene Landström, Malin Melin, Lars Palmqvist, Richard Palmqvist, Bianca Stenmark, Anna Wedell, Malin Karnå, Katarina Nyström, Tobias Strid, Per Sikora, Maria Johansson, Therese Fagerqvist, Mirja Carlsson Möller, Oskar Frisell, Mats Ulfendahl, Mikaela Friedman, Lucia Cavelier, Valtteri Wirta, Thoas Fioretos, Richard Rosenquist   +58 more
wiley   +1 more source

Therapeutic Effects of Ceranib-2 and Irinotecan Combination on Colon Cancer. [PDF]

Curr Issues Mol Biol
Selvi O, Vejselova Sezer C, İzgördü H, Kutlu HM.   +3 more
europepmc   +1 more source

Ellagic Acid Enhances RSL3‐Induced Ferroptosis by Inhibiting the Nrf2/HO‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Ellagic acid potentiates RSL3‐induced ferroptosis in PANC‐1 by suppressing the Nrf2/HO‐1 antioxidant defense axis via p38 MAPK activation and Keap1 upregulation. In PDAC cells, constitutive Nrf2/HO‐1 signaling establishes a robust antioxidant shield (GPX4, HO‐1) that limits lipid ROS accumulation and confers ferroptosis resistance.
Jianhua Bai, Yihe Dai, Chern Ein Oon, Pingping Hu, Jia Luo, Jiang Han, Liman Yang, Amirabas Bostani, Zhenhao Fei, Yun Jin   +9 more
wiley   +1 more source

Deciphering the Formulation-Dependent Neurotoxicity of Irinotecan: An Integrated Pharmacovigilance and Mechanistic Study. [PDF]

J Biochem Mol Toxicol
Shen C, Ma W, Lu J, Tang Y, Cao W.
europepmc   +1 more source

Risk factors for irinotecan-induced hepatotoxicity: a retrospective cohort study. [PDF]

Front Oncol
Alherz FA, Alnakhli AM, Alqarni AM, Alshammari AF, Ruwayi AM, Alyamani RM, Al-Salloum H, Al-Yamani MJ, Shuweihdi F.   +8 more
europepmc   +1 more source

Engineered human adipose-derived stem cells delivering carboxylesterase and TRAIL for castration-resistant prostate cancer: Translational synthesis. [PDF]

Investig Clin Urol
Kim JH, Lee SH, Song YS.
europepmc   +1 more source

Long-Term Response and Survival With Liposomal Irinotecan and Fluorouracil in a Patient With Locally Advanced Pancreatic Ductal Adenocarcinoma: A Case Report. [PDF]

Cureus
Tulyte-Kirzova S, Vitkauskaite E, Gumbys L.   +2 more
europepmc   +1 more source

Efficacy and safety of liposomal irinotecan plus nimotuzumab in immune checkpoint inhibitor-refractory recurrent or metastatic nasopharyngeal carcinoma: a single-arm, open-label, phase II trial. [PDF]

EClinicalMedicine
He S, Bei WX, Lu N, Zhao ZY, Ye Y, Chen C, Tang L, Liu L, Lv S, Xiang YQ, Wang L.   +10 more
europepmc   +1 more source

Impact of prior conventional irinotecan use on nanoliposomal irinotecan efficacy in advanced pancreatic cancer: a meta-analysis. [PDF]

ESMO Open
Lee S, Correa TL, Birda V, Roshan K, Peters ML, Modest AM, Keko M, Bockorny B.   +7 more
europepmc   +1 more source