Results 61 to 70 of about 79,249 (245)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Irinotecan in the treatment of colorectal cancer. A literature review

Тазовая хирургия и онкология, 2017
In 1998, oncologists got a brand new antitumor drug – irinotecan. It’s been already 18 years since its approval for second-line polychemotherapy of metastatic colorectal cancer.
V. A. Ivanov, S. S. Gordeev, A. B. Baychorov,, V. A. Aliev, D. V. Kuz’michev, A. V. Polynovskiy, A. O. Rasulov   +6 more
doaj   +1 more source

Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model. [PDF]

, 2017
Relapsed osteosarcoma is a recalcitrant tumor. A patient's cisplatinum (CDDP)-resistant relapsed osteosarcoma lung metastasis was previously established orthotopically in the distal femur of mice to establish a patient-derived orthotopic xenograft (PDOX)
Dry, Sarah M., Eckardt, Mark A., Eilber, Fritz C., Elliott, Irmina A., Hayashi, Katsuhiro, Hoffman, Robert M., Igarashi, Kentaro, Kawaguchi, Kei, Kimura, Hiroaki, Kiyuna, Tasuku, Li, Yunfeng, Miwa, Shinji, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D., Russell, Tara A., Singh, Arun S., Tsuchiya, Hiroyuki, Yamamoto, Norio, 三輪, 真嗣, 五十嵐, 健太郎, 土屋, 弘行, 山本, 憲男, 林, 克洋   +23 more
core   +1 more source

Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy

Advanced Materials Technologies, EarlyView.
A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi, Franziska Moll, Robert Römer, Andreas Grodrian, Doris Heinrich, Karen Lemke   +5 more
wiley   +1 more source

Risk factors for irinotecan-induced liver injury: a retrospective multicentre cross-sectional study in China

BMJ Open, 2023
Objectives The hepatotoxicity of irinotecan has been widely implicated in the treatment of multiple solid tumours. However, there are few studies on the influencing factors of irinotecan-induced hepatotoxicity.
Yi Xu, Wei Li, Chengliang Zhang, Guangzhao He, Min Chen, Li Zhao, Jianhua Liu, Rui Huang, Zaoqin Yu, Qiuyan Song   +9 more
doaj   +1 more source

A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second-Line Treatment of Metastatic KRAS Mutant Colorectal Adenocarcinoma. [PDF]

, 2017
Lessons learnedThe safety profile in the patient groups who received FOLFIRI and simtuzumab did not differ from that in the FOLFIRI and placebo group.The addition of simtuzumab to chemotherapy with FOLFIRI does not improve clinical outcomes in patients ...
Bendell, Johanna, Benson, Al B, Hecht, J Randolph, Verma, Udit, Vyushkov, Dmitry, Yang, Yingsi   +5 more
core   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer. [PDF]

, 2012
Thus, we evaluated the immunofluorescence pattern of TRAIL-receptors and E-cadherin to assess the fraction of membrane-bound TRAIL-receptors in 231 selected patients with early-stage CRC undergoing surgical treatment only.
De Toni, Enrico N., Gallmeier, Eike, Gerbes, Alexander L., Göke, Burkhard, Hermeking, Heiko, Horst, David, Jackstadt, Rene, Jung, Andreas, Kirchner, Thomas, Kriegl, Lydia, Rizzani, Antonia   +10 more
core   +3 more sources

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Bi-weekly irinotecan is an effective and convenient regimen in the treatment of relapsed or refractory small cell lung cancer

BMC Cancer
Background Despite initial dramatic responses, metastatic small cell lung cancer (SCLC) invariably recurs. Irinotecan is one of the active agents for patients with recurrent SCLC.
Feride Yılmaz, Serkan Yaşar, Ömer Denizhan Tatar, Hasan Çağrı Yıldırım, Deniz Can Güven, Arif Akyıldız, Elvin Chalabiyev, Burak Yasin Aktaş, Zafer Arık, Mustafa Erman   +9 more
doaj   +1 more source