Results 81 to 90 of about 54,010 (241)

Sonographic Diagnosis of an Intercostal Artery Pseudoaneurysm: A Case Report and Literature Review

Journal of Clinical Ultrasound, EarlyView.
A 63‐year‐old male presented to the emergency department after being found unconscious during a welfare check. Following a prolonged three‐month hospital admission, the patient developed left flank pain. Spectral Doppler ultrasound revealed a large isoechoic lesion with layering echoes, and spectral Doppler demonstrated bidirectional flow.
Aaditya P. Singh, Peter R. Coombs
wiley   +1 more source

UGT1A1 polymorphisms in cancer: impact on irinotecan treatment

, 2017
Masashi Takano1 Toru Sugiyama2 1Department of Clinical Oncology, National Defense Medical College Hospital, Tokorozawa, Saitama, 2Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Iwate, Japan Abstract: Mutations in the UGT1A1 ...
Takano M, Sugiyama T
core  

The Negative Impact of a Non‐Therapeutic Laparotomy in Patients With Inoperable Colorectal Peritoneal Metastases

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background The peritoneum is the third most prevalent location for metastases of colorectal cancer. In patients with resectable disease, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC) is the preferred treatment in the Netherlands, achieving median overall survival (OS) of 36–42 months. However, during
Teun van den Heuvel, Lars van Kesteren, Simon Nienhuijs, Pim Burger, Tineke Buffart, Jurriaan Tuynman, Ignace De Hingh   +6 more
wiley   +1 more source

Optimization of irinotecan chronotherapy with P-glycoprotein inhibition

, 2014
The relevance of P-glycoprotein (P-gp) for irinotecan chronopharmacology was investigated in female B6D2F1 mice. A three-fold 24 h change in the mRNA expression of Abcb1b was demonstrated in ileum mucosa, with a maximum at Zeitgeber Time (ZT) 15 (p < 0 ...
VAN DER HORST, Gijsbertus T. J., Levi, Francis, van der Horst, Gijsbertus T. J., Okyar, Alper, Filipski, Elisabeth, Berland, Elodie, Ozturk, Narin, Guettier, Catherine, Lévi, Francis A.   +8 more
core   +2 more sources

Addressing the distressing: Pancreatic enzyme replacement therapy mitigates abdominal symptoms and weight loss during chemotherapy for advanced pancreatic cancer: A prospective study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Pancreatic enzyme insufficiency (PEI) contributes to symptom burden and malnutrition in advanced pancreatic cancer (aPC). We aimed to evaluate the impact of pancreatic enzyme replacement therapy (PERT) on symptom burden and weight during chemotherapy.
Pamela N. Klassen, Christina A. Kim, Jessica Kasnik, Michael B. Sawyer, Sunita Ghosh, Vickie Baracos, Vera C. Mazurak   +6 more
wiley   +1 more source

Irinotecan or FOLFIRI for 2nd line colorectal [PDF]

, 2011
Background Second-line treatment with irinotecan for advanced or metastatic colorectal cancer prolongs survival. It is uncertain whether irinotecan is better administered with 5- fluorouracil or alone in patients previously treated with a ...
Ransom, David T, Gebski, Val, Yip, Sonia, Tebbutt, Niall C, Buck, Martin, Simes, R John, Boland, Amy, Clarke, Stephen, Zalcberg, John, Brown, Chris, Van Hazel, Guy, Lowenthal, Raymond M, Jeffrey, G Mark, Goldstein, David   +13 more
core  

Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review

, 2021
Treatment with pharmacological drugs for colorectal cancer (CRC) remains unsatisfactory. A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs, creating an urgent issue.
Habano, Wataru, Ozawa, Shogo, Miura, Toshitaka, Terashima, Jun   +3 more
core  

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

อิริโนทีแคน ในมุมมองเภสัชพันธุศาสตร์ Irinotecan: Pharmacogenetic Perspective

, 2021
อิริโนทีแคนเป็นยาเคมีบำบัดที่ใช้ในการรักษามะเร็งหลายชนิด ได้แก่ มะเร็งลำไส้ใหญ่และทวารหนัก มะเร็งปอด มะเร็งตับอ่อน ยามีลักษณะเป็น prodrug ที่ต้องผ่านกระบวนการไฮโดรไลซิสล์ (hydrolysis) เป็น 7-ethyl-10-hydroxy-camptothecin (SN-38) ซึ่งเป็นสารที่มีฤทธ ...
Wonganan, Piyanuch, Leksuwankun, Surachai   +1 more
core   +1 more source

Evaluation of pomegranate rind (Punica granatum) hydroethanolic extract on blood parameters in male mice treated by Irinotecan Hcl

Armaghane Danesh Bimonthly Journal, 2015
Background & aim: Irinotecan Hcl is the first order drug for some neoplasm treatment in patients. Irinotecan Hcl has side effects on blood such as anemia and leukopeny.
N Mirazi, Sh Nosrati, A Hosseini
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